环境与健康系

汪一心/ 职称:研究员

学历学位:医学博士 研究生

Email: yixin_wang@shsmu.edu.cn

个人简历

汪一心,上海交通大学公共卫生学院研究员学科带头人。现任上海交通大学公共卫生学院环境与健康系主任。2017年获华中科技大学同济医学院博士学位,哈佛大学陈曾熙公共卫生学院博士后/Lead Scientist(2019-2023)。聚焦生殖流行病学,研究人类生殖健康的环境危险因素和生命早期生殖特征的长远期健康效应。主要研究方向:1)全生育周期生殖特征的远期效应;2)影响育龄人群生殖健康的典型环境污染物及潜在作用机制;3)育龄人群典型环境污染物暴露和生殖健康评估。截止2023年6月,共发表学术论文100余篇,其中第一/通讯作者(含共同)60余篇,如BMJ(3)、JAMA Intern Med、Eur Respir J(2)、Eur Heart J、J Am Coll Cardiol、eClinicalMedicine(2)、JAMA Netw Open(2)、Lancet Reg Health Am(3)、Environ Health Perspect(2)、ES&T(5)、Environ Int(10)等。研究成果被写入《水污染与健康》、《饮用水消毒副产物与健康》、《环境与精准预防》等国家重点图书;成果“水典型污染物毒性、健康风险及评价技术体系”获湖北省科技进步一等奖。担任Sustainable Horizons等青年编委,为Ann Intern Med、Nat Commun等近30种国际权威期刊审稿70余次。田径800/1500米国家二级运动员。

 

研究方向

生殖流行病学

代表性研究成果

发表论著(#共同一作;*通讯作者)

一、全生育周期生殖特征的远期效应(代表性10篇)

1.Wang YX*, Yang Sun, Missmer SA, Rexrode KM, Wang L, Roberts Al, Chavarro JE, Rich-Edwards JW. Association of Childhood Physical and Sexual Abuse with Risk of Premature Mortality in Women: a Prospective Cohort Study. BMJ, 2023; 381:e073613.

2.Wang YX, Arvizu M, Rich-Edwards JW, Stuart JJ, Manson JE, Missmer SA, Pan A, Chavarro JE.Menstrual cycle regularity and length across the reproductive lifespan and risk of premature mortality: prospective cohort study. BMJ, 2020;371:m3464.

3.Wang YX, Mínguez-Alarcón L, Gaskins A, Arvizu M, Missmer S, Rich-Edwards JW, Manson J, Pan A, Chavarro JE. Association of spontaneous abortion with all cause and cause specific premature mortality: prospective cohort study. BMJ, 2021;372:n530.

4.Wang YX, Mínguez-Alarcón L, Wang L, Ding M, Missmer S, Rich-Edwards JW, Manson J, Chavarro JE. Spontaneous abortion and risk of cardiovascular disease: the Nurses’ Health Study II.2021, Eur Heart J, 2021 Oct 27;ehab737.

5.Wang YX*, Mitsunami M, Manson JE, Gaskins AJ, Rich-Edwards JW, Wang L, Zhang C, Chavarro JE. Association of Gestational Diabetes Mellitus with Subsequent Long-term Risk of Mortality: A Large Prospective Cohort Study. JAMA Intern Med, 2023. In Press

6.Wang YX, Arvizu M, Rich-Edwards JW, Wang L, Rosner B, Stuart JJ, Rexrode KM, Chavarro JE. Hypertensive disorders of pregnancy and subsequent risk of premature mortality: a prospective cohort study. 2021, J Am Coll Cardiol, 2021, 77 (10) 1302–1312.

7.Wang YX, Li Y, Rich-Edwards JW, Florio AA, Shan Z, Wang S, Manson JE, Mukamal KJ, Rimm EB, Chavarro JE. Associations of birth weight and later life lifestyle factors with risk of cardiovascular disease in the USA: A prospective cohort study, eClinicalMedicine, 2022;51: 101570.

8.Wang YX, Arvizu M, Rich-Edwards JW, Manson JM, Wang L, Missmer SA, Chavarro JE. Breastfeeding duration and subsequent risk of mortality among US women: results from two prospective cohort studies. eClinicalMedicine, 2022;54:101693.

9.Wang YX, Shan ZL, Arvizu M, Pan A, Manson JE, Missmer SA, Sun Q, Chavarro JE.Associations of menstrual cycle characteristics across the reproductive life span and lifestyle factors with risk of type 2 diabetes: a cohort study, JAMA Netw Open, 2020;3(12):e2027928.

10.Wang YX, Ding M, Li Y, Wang L, Rich-Edwards JW, Florio A, Manson JE, Chavarro JE. Birth weight and risk of total and cause-specific mortality among US men and women: results from three prospective cohort studies, Lancet Reg Health Am, 2022;15:100344.


二、影响育龄人群生殖健康的典型环境污染物及潜在作用机制(代表性10篇)

1. Sun Y, Xia PF, Xie J, Mustieles V, Zhang Y,  Wang YX*, Messerlian C. Association of blood trihalomethane concentrations with asthma in U.S. adolescents: nationally representative cross-sectional study. 2021, Eur Respir J, 2021;2101440.

2. Sun Y, Wang YX*, Mustieles V, Zhang Y, Pan XF, Messerlian C. Association of blood trihalomethane concentrations with lung function in U.S. adolescents: a nationally representative cross-sectional study.Eur Respir J, 2022;60(1):2200753.

3. Sun Y, Wang YX*, Wang Q, Liu C, Chen YJ, Lu WQ*, and Messerlian C. Trimester-Specific Blood Trihalomethane and Urinary Haloacetic Acid Concentrations and Adverse Birth Outcomes: Identifying Windows of Vulnerability during Pregnancy. Environ Health Perspect. 2020;128(10):107001.

4.Wang YX, Zhou B, Chen YJ, Liu C, Huang LL, Liao JQ, Hu XJ, Lu WQ, Zeng Q, Pan A. Thyroid function, phthalate exposure and semen quality: Exploring associations and mediation effects in reproductive-aged men. Environ Int, 2018;116:278-285.

5.Wang YX#, Sun Y#, Huang Z, Wang P, Feng W, Li J, Yang P, Wang M, Sun L, Chen YJ, Liu C, Yue J, Gu LJ, Zeng Q, Lu WQ. Associations of urinary metal levels with serum hormones, spermatozoa apoptosis and sperm DNA damage in a Chinese population. Environ Int, 2016;94:177-188.

6.Wang YX, Sun Y, Feng W, Wang P, Yang P, Li J, Huang Z, Chen YJ, Liu C, Sun L, Yue J, Gu LJ, Zeng Q, Lu WQ. Association of urinary metal levels with human semen quality: A cross-sectional study in China. Environ Int, 2016;91:51-9.

7.Wang YX#, Wu Y#, Chen HG, Duan P, Wang L, Shen HQ, Lu WQ, Sun B, Wang Q, Zhang B, Chavarro JE, Zhang J, Pan A. Seminal plasma metabolome in relation to semen quality and urinary phthalate metabolites among Chinese adult men. Environ Int, 2019;129:354-363.

8.Liu C, Messerlian C, Chen YJ, Mustieles V, Huang LL, Sun Y, Deng YL, Cheng YH, Liu J, Liu AM, Lu WQ*, Wang YX*. Trimester-specific associations of maternal exposure to disinfection by-products, oxidative stress, and neonatal neurobehavioral development. Environ Int. 2021 Aug 25; 157:106838.

9.Liu C, Wang YX*, Chen YJ, Sun Y, Huang LL, Cheng YH, Liu EN, Lu WQ*, Messerlian C. Blood and urinary biomarkers of prenatal exposure to disinfection byproducts and oxidative stress: A repeated measurement analysis. Environ Int, 2020;137:105518.

 10.Chen YJ, Liu C, Tu ZZ, Lu Q, Messerlian C, Mustieles V, Sun Y, Lu WQ, Pan XF, Mao C*, Wang YX*. Associations of Urinary Trichloroacetic Acid Concentrations with Spermatozoa Apoptosis and DNA Damage in a Chinese Population. Environ Sci Technol, 2022; 56(10):6491-6499. PMID: 35472294.


三、育龄人群典型环境污染物暴露评估(代表性5篇)

1.Wang YX, Feng W, Zeng Q, Sun Y, Wang P, You L, Yang P, Huang Z, Yu SL, Lu WQ. Variability of Metal Levels in Spot, First Morning, and 24-Hour Urine Samples over a 3-Month Period in Healthy Adult Chinese Men. Environ Health Perspect, 2016;124(4):468-76.

2.Wang YX#, Liu C#, Shen Y#, Wang Q, Pan A, Yang P, Chen YJ, Deng YL, Lu Q, Cheng LM, Miao XP, Xu SQ, Lu WQ, Zeng Q. Urinary levels of bisphenol A, F and S and markers of oxidative stress among healthy adult men: Variability and association analysis. Environ Int, 2019; 123:301-309.

3.Wang YX#, Zeng Q#, Wang L, Huang YH, Lu ZW, Wang P, He MJ, Huang X, Lu WQ. Temporal variability in urinary levels of drinking water disinfection byproducts dichloroacetic acid and trichloroacetic acid among men. Environ Res, 2014;135:126-32.

4.Wang YX, Liu C, Chen YJ, Duan P, Wang Q, Chen C, Sun Y, Liu C, et al., Profiles, variability and predictors of concentrations of blood trihalomethanes and urinary haloacetic acids along pregnancy among 1760 Chinese women. Environ Res, 2019; 172:665-674.

5.Liu N, Chen hg, Yu Lia Y, Zhang G, Zhang J, Qu G, He B, Meng TQ, Xiong CL, Pan A, Yin Y, Liang Y, Shi J, Wang YX*, Hu L*, Jianga GB, Exogenous Metals Atlas in Spermatozoa at Single-Cell Resolution in Relation to Human Semen Quality. Environ Sci Technol, 2023;57(19):7358-7369.


发表论著详见:

https://www.researchgate.net/profile/Yixin-Wang-11

https://www.webofscience.com/wos/author/record/AAI-2758-2021