沈阳药科大学学士，理学博士（日本大冢制药研究所联合培养）。2003-2006年日本NIHS博士后。2006-2013年中科院上海药物研究所工作。2012年美国FDA毒理研究院访问学者。2013年起就职于上海交通大学医学院。

学术兼职为《Mutation Research-Genetic Toxicology and Environmental Mutagenesis》区域编辑，《Mutagenesis》、《Genes and Environment》和《癌变畸变突变》杂志编委。作为国际遗传毒性测试专家工作组（IWGT）成员和OECD遗传毒性指南工作组成员参与相关工作。担任中国毒理学会遗传毒理专委会副主任、中国环境诱变剂学会常务理事，上海市毒理学会常务理事等。

我们研究小组致力于探究外源化学物质对机体遗传物质的损伤、致突变和致癌作用，对象包括环境污染物、药物、农药和烟草等。我们利用小鼠、培养细胞和线虫等工具，考察上述物质对机体健康的损害机制。这些研究不仅揭示了环境与基因之间有趣的交互作用，更重要的是，为人类健康风险的预测与疾病的诊断与治疗提供了有用的信息。

我们对马兜铃酸——一种药用植物来源的天然化合物，进行了多年的研究。它是多种中药的有效成分，但是近年来被发现具有很强的致癌作用和肾毒性。作为祖先留下的瑰宝，我们的目的不是通过毒性评价给它贴上“有毒”的标签，而是弄清楚它的毒性机制。我们希望鉴别出高危人群，明确什么样的人不能用这些中药。我们想阐明它发挥毒性和药效活性的化学结构，目前我们已找到了无毒性的马兜铃酸，并且正在探索它的药物活性和作用靶点，继续通过结构改造希望把它开发成为新型药物，让祖先的智慧在现代医学中焕发新生。我们还借助了大自然的神奇力量，自然界里有一类蝴蝶只食用这类有毒植物，通过研究蝴蝶如何耐受马兜铃酸毒性，我们还找到了有望对抗马兜铃酸肾毒性的靶点。对马兜铃酸的研究已成为我们研究组一个重要的研究方向。

除马兜铃酸外，我们也对一些环境污染物的毒性机制进行了研究。生命科学快速发展，给我们提供了诱变剂与DNA作用机制的新线索。我们正在研究喹啉与DNA二级结构G-四联体的相互作用，发现它导致的独特突变可能与DNA这个结构有关，我们对其深入的研究还将揭示出更多的精彩故事。

工欲善其事，必先利其器。我们同时也在努力开发这个领域的新技术。体细胞突变是肿瘤、衰老和其他多种疾病发生发展的重要原因，但是，早期突变由于基因组上发生频率极低和细胞散在发生，难以被测序错误率很高的普通二代测序技术检测到。我们自主创新建立了纠错测序技术，可实现体细胞全基因组范围内超低频突变的检测。我们的研究起步较早，与国际该领域的领先团队位于同一梯队和水平。国际上目前已达成共识，将该类技术替代经典体内致突变实验，率先用于新药研发领域。同时，整合动物实验和人群研究，我们正在将该技术用于复杂环境因素与人类疾病的关联研究。除此之外，我们还开发了以检测基因突变频率为终点的人群监测方法——人群外周血PIG-A突变检测技术。它作为一个新的效应标志可用于人类致癌风险的预测，最终降低外源化学诱变剂对人类健康的危害。

迄今承担的国家自然科学基金项目：环境诱变剂喹啉与DNA二级结构G-四联体相互作用介导其诱发G:C>C:G特征突变机制研究(22476128); 马兜铃酸物质基础与致癌毒性研究( 81873081)；一种基于全基因组测序的化学物致突变测试评价方法的研究(82304267); 多溴联苯醚（PBDEs）的生殖遗传毒性研究(21477078)；建立新的动物模型研究肝脏P450酶对致癌物遗传毒性的影响( 21077112)；新的遗传毒性分子生物标志物的探索与研究（20807045)。

近五年发表论文（2025-2020）

1.  You X, Sun C, Cao Y, Xi J, Liu W, Wu J, Zheng J, Luan Y*. Quantitative genotoxicity assessment of N-nitrosodimethylamine in mice by error-corrected next-generation sequencing and DNA methylation quantification for toxicity threshold determination. Arch Toxicol. 2025 in press.

2. Gao Q, Liu W, Jawad M, Ci L, Cao Y, Xi J, Wu J, Lei Y, Hu Y, You X, Zhang X, Fei J*, Luan Y*. Aristolochic acid IVa ameliorates arthritis in SKG Mice by regulating macrophage polarization and Th17/Treg balance. Phytomedicine. 2025 Apr;139:156557. doi: 10.1016/j.phymed.2025.156557. Epub 2025 Feb 23. PMID: 40043543.

3. Lei Y, Hu Y, Cao Y, Xi J, Ma Y, Zhang X, Gao Q, Fu J, Zhang X, Su L*, Luan Y*. Mitochondrial DNA leakage and micronucleus formation activate the cGAS-STING pathway in aristolochic acid I-induced nephritis. Food Chem Toxicol. 2025 Jul 16;204:115648. doi: 10.1016/j.fct.2025.115648. Epub ahead of print. PMID: 40681081.

4. Wu J, You X, Cao Y, Xi J, Chen X, Zhang X, Luan Y*. High-throughput neurotoxicity study of neonicotinoids in C. elegans: Oxidative stress and serotonergic neuronal damage as key mechanisms. Environ Pollut. 2025 Jul 10;383:126814. doi: 10.1016/j.envpol.2025.126814. Epub ahead of print. PMID: 40651652.

5. Hu Y, Lei Y, Gao Z, Cao Y, Xi J, Ma Y, Gao Q, Fu J, Zhang X, Luan Y*. Genotoxic effects of aristolochic acid I on functional human-induced hepatocyte-like cells. Mutagenesis. 2025 May 26:geaf012. doi: 10.1093/mutage/geaf012. Epub ahead of print. PMID: 40417995.

6. Gao J, Zhao M, Su J, Gao Y, Zhang X, Ding Y, Liu X, Luan Y*, Hu C*. Synthesis and Cytotoxicity Evaluation of Denitroaristolochic Acids: Structural Insights and Mechanistic Implications in Nephrotoxicity. Biomolecules. 2025 Jul 14;15(7):1014. doi: 10.3390/biom15071014. PMID: 40723885; PMCID: PMC12293755.

7. 高振娜, 尤馨悦, 刘维映, 吴佳颖, 奚晶, 曹易懿, 张小红, 张新宇, 栾洋*. 人醛酮还原酶1A1参与致癌物马兜铃酸Ⅰ的代谢活化（英文）[J].中国药理学与毒理学杂志,2024,38(09):641-651.

8. Zhang X, Zhao T, Liu W, Xi J, Yao D, Cao Y, You X, Wu J, Gao Z, Lei Y, Zhou C, Zhang X, Zheng J*, Luan Y*. Quinoline is more genotoxic than 4-methylquinoline in hiHeps cells and rodent liver. Mutat Res Genet Toxicol Environ Mutagen. 2023 Feb-Mar;886:503582. doi: 10.1016/j.mrgentox.2022.503582. Epub 2022 Dec 29. PMID: 36868699.

9. Xi J, Cao Y, Wang Y, You X, Liu W, Wang T, Yin J, Ma J, Wang Z, Wu N, Zhang X, Duan H*, Luan Y*. PIG-A gene mutation as a mutagenicity biomarker among coke oven workers. Food Chem Toxicol. 2023 Aug;178:113872. doi: 10.1016/j.fct.2023.113872. Epub 2023 Jun 2. PMID: 37271276.

10. You X, Cao Y, Suzuki T, Shao J, Zhu B, Masumura K, Xi J, Liu W, Zhang X, Luan Y*. Genome-wide direct quantification of in vivo mutagenesis using high-accuracy paired-end and complementary consensus sequencing. Nucleic Acids Res. 2023 Nov 27;51(21):e109. doi: 10.1093/nar/gkad909. PMID: 37870450; PMCID: PMC10681716.

11. Liu W, Yasui M, Sassa A, You X, Wan J, Cao Y, Xi J, Zhang X, Honma M, Luan Y*. FTO regulates the DNA damage response via effects on cell-cycle progression. Mutat Res Genet Toxicol Environ Mutagen. 2023 Apr;887:503608. doi: 10.1016/j.mrgentox.2023.503608. Epub 2023 Feb 28. PMID: 37003652.

12. Cao Y, Wang T, Xi J, Tian W, Liu W, Sun Y, Liu W, You X, Li A, Zhang G, Zhang X, Xia ZL, Luan Y*. Benchmark dose estimation for benzene-exposed workers in China: Based on quantitative and multi-endpoint genotoxicity assessments. Environ Pollut. 2023 Aug 1;330:121765. doi: 10.1016/j.envpol.2023.121765. Epub 2023 May 2. PMID: 37142205.

13. Liu W, Shao F, You X, Cao Y, Xi J, Wu J, Wan J, Zhang X, Fei J, Luan Y*. Non-carcinogenic/non-nephrotoxic aristolochic acid IVa exhibited anti-inflammatory activities in mice. J Nat Med. 2023 Mar;77(2):251-261. doi: 10.1007/s11418-022-01665-8. Epub 2022 Dec 16. PMID: 36525161.

14. Wu J, Gao Y, Xi J, You X, Zhang X, Zhang X, Cao Y, Liu P, Chen X*, Luan Y*. A high-throughput microplate toxicity screening platform based on Caenorhabditis elegans. Ecotoxicol Environ Saf. 2022 Oct 15;245:114089. doi: 10.1016/j.ecoenv.2022.114089. Epub 2022 Sep 18. PMID: 36126550.

15. Luan, Y*., Honma, M. Genotoxicity testing and recent advances. GENOME INSTAB. DIS. 3, 1–21 (2022). https://doi.org/10.1007/s42764-021-00058-7

16. Takeda, S., Luan, Y*. Nature of spontaneously arising single base substitutions in normal cells. GENOME INSTAB. DIS. 2, 339–357 (2021). https://doi.org/10.1007/s42764-021-00056-9

17.Chen R, You X, Cao Y, Masumura K, Ando T, Hamada S, Horibata K, Wan J, Xi J, Zhang X, Honma M, Luan Y*. Benchmark dose analysis of multiple genotoxicity endpoints in gpt delta mice exposed to aristolochic acid I. Mutagenesis. 2021 Apr 28;36(1):87-94. doi: 10.1093/mutage/geaa034. PMID: 33367723.

18. Wan J, Chen R, Yang Z, Xi J, Cao Y, Chen Y, Zhang X*, Luan Y*. Aristolochic acid IVa forms DNA adducts in vitro but is non-genotoxic in vivo. Arch Toxicol. 2021 Aug;95(8):2839-2850. doi: 10.1007/s00204-021-03077-1. Epub 2021 Jul 5. PMID: 34223934.

19. Xu L, Gao S, Zhao H, Wang L, Cao Y, Xi J, Zhang X, Dong X*, Luan Y*. Integrated Proteomic and Metabolomic Analysis of the Testes Characterizes BDE-47-Induced Reproductive Toxicity in Mice. Biomolecules. 2021 May 31;11(6):821. doi: 10.3390/biom11060821. PMID: 34072909; PMCID: PMC8229108.

20. Cao Y, Xi J, Tang C, Yang Z, Liu W, You X, Feng N, Zhang XY, Wu J, Yu Y, Luan Y*. PIG-A gene mutation as a genotoxicity biomaker in polycyclic aromatic hydrocarbon-exposed barbecue workers. Genes Environ. 2021 Dec 9;43(1):54. doi: 10.1186/s41021-021-00230-1. PMID: 34879859; PMCID: PMC8656086.

21. Cao Y, Xi J, You X, Liu W, Luan Y*. Dose-response genotoxicity of triclosan in mice: an estimate of acceptable daily intake based on organ toxicity. Toxicol Res (Camb). 2021 Nov 8;10(6):1153-1161. doi: 10.1093/toxres/tfab098. PMID: 34956618; PMCID: PMC8692727.

22. Takeda, S., Luan Y*. Nature of spontaneously arising single base substitutions in normal cells.GenomeInstab. Dis. 2021. 2, 339-357.

23. Chen R, Zhou C, Cao Y, Xi J, Ohira T, He L, Huang P, You X, Liu W, Zhang X, Ma S, Xie T, Chang Y, Luan Y*. Assessment of Pig-a, Micronucleus, and Comet Assay Endpoints in Tg.RasH2 Mice Carcinogenicity Study of Aristolochic Acid I. Environ Mol Mutagen. 2020 Feb;61(2):266-275. doi: 10.1002/em.22325. Epub 2019 Sep 30. PMID: 31443125.

24. Cao Y, Wang T, Xi J, Zhang G, Wang T, Liu W, You X, Zhang X, Xia Z*, Luan Y*. PIG-A gene mutation as a genotoxicity biomarker in human population studies: An investigation in lead-exposed workers. Environ Mol Mutagen. 2020 Jul;61(6):611-621. doi: 10.1002/em.22373. Epub 2020 Apr 27. PMID: 32285465.

25.  Cao Y, Wang X, Liu W, Feng N, Xi J, You X, Chen R, Zhang X, Liu Z, Luan Y*. The potential application of human PIG-A assay on azathioprine-treated inflammatory bowel disease patients. Environ Mol Mutagen. 2020 Apr;61(4):456-464. doi: 10.1002/em.22348. Epub 2019 Dec 6. PMID: 31743483.

26. You X, Thiruppathi S, Liu W, Cao Y, Naito M, Furihata C, Honma M, Luan Y*, Suzuki T*. Detection of genome-wide low-frequency mutations with Paired-End and Complementary Consensus Sequencing (PECC-Seq) revealed end-repair-derived artifacts as residual errors. Arch Toxicol. 2020 Oct;94(10):3475-3485. doi: 10.1007/s00204-020-02832-0. Epub 2020 Jul 31. PMID: 32737516.