2003年毕业于沈阳药科大学，获药理学博士学位（2000-2001年于日本大冢制药株式会社研究所进行博士课题研究）。2003-2006年于日本国立医药品食品卫生研究所（NIHS）从事博士后研究（遗传毒理学）。2006-2013年受聘于中科院上海药物研究所药物安全性评价与研究中心毒理研究部门并入选上海市浦江人才计划。受聘期间，于2012年1月至4月作为作为访问学者在美国FDA国家毒理研究院进行学术交流；于2012年5月至11月作为新药审评员在国家药品监督管理局药品审评中心进行新药审评工作。2013年起任上海交通大学医学院公共卫生学院研究员、毒理学课题研究组组长和公共卫生学院实验平台主任。作为课题负责人主持国家自然科学基金面上项目3项、青年基金项目1项；作为主要参与人参与国家自然科学基金重大项目1项；指导课题组博士后获得国家自然科学基金青年基金项目1项。

学术任职：任Mutation Research-Genetic Toxicology and Environmental Mutagenesis杂志区域编辑、Mutagenesis杂志编委、Genes & Environment杂志编委、《癌变畸变突变》杂志编委、中国毒理学会遗传毒理专业委员会副主任、中国环境诱变剂学会常务理事、上海市毒理学会常务理事、上海环境诱变剂学会理事、OECD遗传毒性测试指南专家工作组成员等。

研究方向为遗传毒理，主要为新技术开发和外源化合物毒性机理研究.构建了本研究领域较为前沿的体内、体外试验模型及方法；探索的新技术包括基于一致性测序的低频突变检测方法，新遗传学损伤效应标志人外周血PIG-A基因突变试验，基于微流控和微孔板体系的单线虫高通量毒性测试方法等；此外，通过DNA加合物检测、体外培养细胞DNA损伤、染色体畸变和基因突变检测、转基因动物基因突变检测等体系，结合分子生物学手段，对环境污染物及中药有毒成分进行毒性评价和机制研究。

1. You X, Cao Y, Suzuki T, Shao J, Zhu B, Masumura K, Xi J, Liu W, Zhang X, Luan Y*. Genome-wide direct quantification of in vivo mutagenesis using high-accuracy paired-end and complementary consensus sequencing.Nucleic Acids Res. 2023. gkad909, https://doi.org/10.1093/nar/gkad909.

2. Liu W, Shao F, You X, Cao Y, Xi J, Wu J, Wan J, ZhangX, Fei J, Luan Y*. Non-carcinogenic/non-nephrotoxic aristolochic acid IVa exhibited anti-infammatory activities in mice.J Nat Med. 2023. 77(2):251-261.

3. Cao Y, Wang T, Xi J, Tian W, Liu W, Sun Y, Liu W, You X, Li A, Zhang G, Zhang X, Xia Z, Luan Y*. Benchmark dose estimation for benzene-exposed workers in China: Based on quantitative and multi-endpoint genotoxicity assessments.Environ Pollut. 2023. 330:121765.

4. Liu W, Yasui M, Sassa A, You X, Wan J, Cao Y, Xi J, Zhang X, Honma M, Luan Y*. FTO regulates the DNA damage response via effects on cell-cycle progression.Mutat Res Genet Toxicol Environ Mutagen. 2023. 887:503608.

5. Zhang X, Zhao T, Liu W, Xi J, Yao D, CaoY, You X, Wu J, Gao Z, Lei Y, Zhou C, Zhang X, Zheng J*, Luan Y*. Quinoline is more genotoxic than 4-methylquinoline in hiHeps cells and rodent liver.Mutat Res Genet Toxicol Environ Mutagen. 2023.886:503582.

6. Xi J, Cao Y, Wang Y, You X, Liu W, Wang T, Yin J, Ma J, Wang Z, Wu N, Zhang X, Duan H, Luan Y*. PIG-A gene mutation as a mutagenicity biomarker among coke oven workers.Food Chem Toxicol. 2023. 178:113872.

7. Wu J, Gao Y, Xi J, You X, Zhang X, Zhang X, Cao Y, Liu P, Chen X, Luan Y*. A high-throughput microplate toxicity screening platform based onCaenorhabditis elegans.Ecotoxicol Environ Saf. 2022. 245:114089.

8. Luan Y*, Honma M*. Genotoxicity testing and recent advances.GenomeInstab. Dis. 2022. 3, 1-21.

9. Takeda S*, Luan Y*. Nature of spontaneously arising single base substitutions in normal cells.GenomeInstab. Dis. 2022. 3, 1-21.

10. Wan J, Chen R, Yang Z, Xi J, Cao Y, Chen Y, Zhang X, Luan Y*. Aristolochic acid IVa forms DNA adducts in vitro but is non-genotoxic in vivo.Arch Toxicol. 2021. 95(8):2839-2850.

11. Xu L, Gao S, Zhao H, Wang L, Cao Y, Xi J, Zhang X, Dong X, Luan Y*. Integrated Proteomic and Metabolomic Analysis of the Testes Characterizes BDE-47-Induced Reproductive Toxicity in Mice.Biomolecules. 2021 May 31;11(6):821.

12. Chen R, You X, Cao Y, Masumura K, Ando T, Hamada S, Horibata K, Wan J, Xi J, Zhang X, Honma M, Luan Y*.Benchmark dose analysis of multiple genotoxicity endpoints in gpt delta mice exposed to aristolochic acid I.Mutagenesis. 2021 Apr 28;36(1):87-94.

13. Takeda, S., Luan Y*. Nature of spontaneously arising single base substitutions in normal cells.GenomeInstab. Dis. 2021. 2, 339-357.

14. You X, Thiruppathi S, Liu W, Cao Y, Naito M, Furihata C, Honma M, Luan Y*, Suzuki T. Detection of genome-wide low-frequency mutations with Paired-End and Complementary Consensus Sequencing (PECC-Seq) revealed end-repair-derived artifacts as residual errors.Arch Toxicol. 2020 Oct;94(10):3475-3485.

15. Cao Y, Wang T, Xi J, Zhang G, Wang T, Liu W, You X, Zhang X, Xia Z, Luan Y*. PIG-A gene mutation as a genotoxicity biomarker in human population studies: An investigation in lead-exposed workers.Environ Mol Mutagen. 2020 Jul;61(6):611-621.

16. Cao Y, Wang X, Liu W, Feng N, Xi J, You X, Chen R, Zhang X, Liu Z, Luan Y*. The potential application of human PIG-A assay on azathioprine-treated inflammatory bowel disease patients.Environ Mol Mutagen. 2020 Apr;61(4):456-464.

17. Chen R, Zhou C, Cao Y, Xi J, Ohira T, He L, Huang P, You X, Liu W, Zhang X, Ma S, Xie T, Chang Y, Luan Y*.Assessment of Pig-a, Micronucleus, and Comet Assay Endpoints in Tg.RasH2 Mice Carcinogenicity Study of Aristolochic Acid I.Environ Mol Mutagen. 2020 Feb;61(2):266-275.