Name：Zhaojun Wang
 Degree：PhD                  
 Title：Professor, Executive Vice-Dean of School of Global Health
 Email Address: zjwang@sjtu.edu.cn
 Office Address: 280 South Chongqing Road
 Office Tel: 021-63846590-776975

Executive Vice dean of School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine.
Professor in the Department of Microbiology and Immunology in Shanghai Jiao Tong University School of Medicine.
Principle Investigator in Shanghai Institute of Immunology.

Prof. Wang obtained her B.Med in Medical Laboratory Science and M.Sc in Microbiology at Shanghai Second Medical University. She received her Ph.D. degree in Immunology from Shanghai Jiao Tong University in 2006. In 2008, Dr. Wang became a Postdoctoral Researcher in the Department of Pathology and Laboratory Science, University of Pennsylvania School of Medicine and returned to Shanghai Jiao Tong University School of Medicine in 2012.

Prof. Wang is an expert in the research of infectious diseases. Her lab focuses on how leukocytes adapt to infectious or inflammatory environments and regulate their functions in response to diverse pathogens, such as protozoa and helminths. She has published more than 50 original research articles in peer-reviewed journals such as Nature Immunology, PNAS, Cell death and differentiation.

Prof. Wang is a Zhiyuan Honors Teaching Faculty in Shanghai Jiao Tong University. As a Principle Teacher and Course Leader, She is response for Foundation of Diseases, Medical Microbiology and Parasitology courses, Global Health and One Health for undergraduate and graduate students.

Education：
Ph.D in Immunology, Shanghai Jiao Tong University, China
Master in Microbiology and Parasitology, Shanghai Second Medical University, China
Bachelor in Medical laboratory science, Shanghai Second Medical University, China

Appointments：
1996 - 2005     Shanghai Second Medical University, Teaching Assistant, Lecturer and Associate Professor
2005 - Present  Shanghai Jiao Tong University School of Medicine, Associate and Full Professor
2008 - 2012     University of Pennsylvania School of Medicine, Postdoctoral Researcher
2017 - Present  Faculty development department, Shanghai Jiao Tong University School of Medicine, Vice director
2021 - Present  Shanghai Institute of Immunology, Principal Investigator
2023 - Present  School of Global Health, School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Executive Vice dean

Academic Participation and Activities：
1. Guo X., Lei Y., Xu Y., Du X., Lin L., Luo Y., Xi Y., Guo Y., Niu X., Wang Z.#, Chen G#. PRL2 negatively regulates fcepsilonri mediated activation of mast cells. Cell Death Dis. 2025;16(1):322.
2. Lei Yunxuan, Guo Xin, Luo Yanping, Niu Xiaoyin, Xi Yebin, Xiao Lianbo, He Dongyi, Bian Yanqin, Zhang Yong, Wang Li, Peng Xiaochun, Wang Zhaojun#, Chen Guangjie#. Synovial microenvironment-influenced mast cells promote the progression of rheumatoid arthritis. Nat Commun. 2024;15(1):113.
3. Du Xinyue, Ren Baiyang, Li Chang, Li Qi, Kan Shuo, Wang Xin, Bai Wenjuan, Wu Chenyun, Kassegne Kokouvi, Yan Huibo, Niu Xiaoyin, Yan Min, Xu Wenyue, Wassmer Samuel C., Wang Jing, Chen Guangjie#, Wang Zhaojun#. PRL2 regulates neutrophil extracellular trap formation which contributes to severe malaria and acute lung injury. Nat Commun. 2024;15(1):881.
4. Li Q., Yue T., Du X., Tang Z., Cui J., Wang W., Xia W., Ren B., Kan S., Li C., Wu C., Niu X., Li B., Lin K., Luo J., Chen G.#, Wang Z#. Hsc70 mediated autophagic degradation of oxidized PRL2 is responsible for osteoclastogenesis and inflammatory bone destruction. Cell Death Differ. 2023;30(3):647-659.
5. Kan Shuo, Li Qi, Li Hong-Mei, Yao Yan-Hua, Du Xin-Yue, Wu Chen-Yun, Chen Guang-Jie, Guo Xiao-Kui, Qian Men-Bao, Wang Zhao-Jun#. Clonorchis sinensis infection modulates key cytokines for essential immune response impacted by sex. PLoS Negl Trop Dis. 2022;16(9):e0010726.
6. Wu Chenyun, Du Xinyue, Tang Lili, Wu Jianhua, Zhao Wei, Guo Xiaokui, Liu Dengyu, Hu Wei, Helmby Helena, Chen Guangjie, Wang Zhaojun#. Schistosoma japonicum sjE16.7 protein promotes tumor development via the receptor for advanced glycation end products (RAGE). Front Immunol. 2020;11:1767.
7. Yin C., Wu C., Du X., Fang Y., Pu J., Wu J., Tang L., Zhao W., Weng Y., Guo X., Chen G., Wang Z#. PRL2 controls phagocyte bactericidal activity by sensing and regulating ros. Front Immunol. 2018;9:2609.
8. Fayngerts S. A*., Wang Z*., Zamani A., Sun H., Boggs A. E., Porturas T. P., Xie W., Lin M., Cathopoulis T., Goldsmith J. R., Vourekas A., Chen Y. H. Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein tipe2. Nat Immunol. 2017;18(12):1353-1360.
9. Wang Z.*, Fayngerts S., Wang P., Sun H., Johnson D. S., Ruan Q., Guo W., Chen Y. H. Tipe2 protein serves as a negative regulator of phagocytosis and oxidative burst during infection. Proc Natl Acad Sci U S A. 2012;109(38):15413-15418.
10. Wang Z.*, Hong J., Sun W., Xu G., Li N., Chen X., Liu A., Xu L., Sun B., Zhang J. Z. Role of ifn-gamma in induction of foxp3 and conversion of cd4+ cd25- t cells to cd4+ tregs. J Clin Invest. 2006;116(9):2434-2441.

Research Interest：Infection and Immunity
Innate host immunity is the first line of defense against pathogen infection, playing a critical role in host resistance to pathogenic microorganisms. Prof Wang’s lab focuses on how leukocytes adapt to infectious or inflammatory environments and regulate their functions in response to diverse pathogens, such as protozoa and helminths.