- Biography
- Education & Experience
- Publications
- Lab Member
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Dr. Li graduated from Nankai University with B.S. and M.S. degrees, then obtained his Ph.D. degree in Biochemistry in 2011 in Vincenzo Pirrotta lab at Rutgers, the state University of New Jersey, working on Polycomb mediated long-distance chromatin interactions in Drosophila. He continued his postdoc training with Dr. Richard Flavell at Yale University School of Medicine since 2012, working on regulatory RNAs and RNA epigenetic switches of the immune system.
Dr. Li established his independent lab at Shanghai Jiao Tong University School of Medicine since 2017. The lab is especially interested in the physiological functions and molecular mechanisms of RNA epigenetic modifications and related RNA binding proteins in immune cells and related immune disease with mouse disease models. Combined with the state-of-the-art technologies and international collaboration, we aim to reveal novel fucntions and mechanisms of inflammation and autoimmune disease, which will contribute to the identification of potential targets for anti-autoimmune and anti-tumor drug development.
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Education
2005-2011 Rutgers University / UMDNJ, Piscataway, NJ, USA, Ph.D.
2002-2005 Nankai University, Tianjin, China, M.S.
1999-2002 Nankai University, Tianjin, China, B.S.
Experience
2017-present Shanghai Institute of Immunology Principal Investigator
2017-present Yale University School of Medicine Assistant Professor Adjunct
2012-2017 Yale University Post-Doctoral Fellow
2011-2012 Rutgers University Post-Doctoral Associate
2006-2011 Rutgers University Research Assistant
2002-2005 Nankai University Research & Teaching Assistant
1.Li HB, Muller M, Bahechar I, Kyrchanova O, Ohno K, Georgiev P, and Pirrotta V,Insulators, not Polycomb Response Elements, are required for long-range interactions between Polycomb targets in Drosophila,Mol. Cell. Biol,2011,31(4):616-25.[Link]
2.Pirrotta V., and Li HB,A view of nuclear Polycomb bodies,Curr. Opin. Genet. Dev,2012,22(2):101-9.[Link]
3.Schwartz YB, Linder-Basso D, Kharchenko PV, Tolstorukov MY, Kim M, Li HB, Gorchakov AA, Minoda A, Shanower G, Alekseyenko AA, Riddle NC, Jung YL, Gu T, Plachetka A, Elgin SC, Kuroda MI, Park PJ, Savitsky M, Karpen GH, Pirrotta V,Nature and function of insulator protein binding sites in the Drosophila genome,Genome Res,2012,22(11): 2188-98.[Link]
4.Li HB, Ohno K, Gui H, and Pirrotta V,Insulators target active genes to transcription factories and Polycomb-repressed genes to PcG bodies,PLoS Genet,2013,9(4):e1003436.[Link]
5.Li HB*, Jin C*, Chen Y*, Flavell RA,Inflammasome activation and metabolic disease progression,Cytokine Growth Factor Rev,2014,25(6):699-706.[Link]
6.Zhu S*, Li HB*, Flavell RA,Resemble and Inhibit: When RLR Meets TGF-β,Mol Cell,2014,56(6):719-20.[Link]
7.Cao G*, Li HB*, Yin Z, Flavell RA,Recent advances in dynamic m6A RNA modification,Open Biology,2016,6(4): 160003.[Link]
8.Li HB,Chromosome Conformation Capture in Drosophila,Methods Mol. Biol.,2016,1480:207-12.[Link]
9.Hu B*, Jin C*, Li HB*, Tong J, Ouyang X, Cetinbas NM, Zhu S, Strowig T, Lam FC, Zhao C, Henao-Mejia J, Yilmaz O, Fitzgerald KA, Eisenbarth SC, Elinav E, Flavell RA,The DNA Sensing Aim2 Inflammasome Controls Radiation Induced Cell death and Tissue Injury,Science,2016,354 (6313): 765-768.[Link]
10.Zhu S, Ding S, Wang P, Wei Z, Pan W, Palm NW, Yang Y, Yu H, Li HB, Wang G, Lei X, de Zoete MR, Zhao J, Zheng Y, Chen H, Zhao Y, Jurado KA, Feng N, Shan L, Kluger Y, Lu J, Abraham C, Fikrig E, Greenberg HB, Flavell RA,Nlrp9b inflammasome recognizes and restricts rotavirus infection in intestinal epithelial cells,Nature,2017,546(7660): 667-670.[Link]
11.Li HB*#, Tong J*, Zhu S*, Batista PJ, Duffy EE, Zhao J, Bailis W, Cao G, Kroehling L, Chen Y, Wang G, Broughton JP, Chen YG, Kluger Y, Simon MD, Chang HY, Yin Z#, Flavell RA#,m6A mRNA methylation controls T cell homeostasis by targeting IL-7/STAT5/SOCS pathway,Nature,2017,548(7667): 338-342.[Link]
12.Tong J*, Cao G*, Zhang T*, Sefik E, Vesely M, Broughton J, Zhu S, Li H, Li B, Chen L, Chang HY, Su B, Flavell RA#, Li HB#,m6A mRNA methylation sustains Treg suppressive functions,Cell Research,2018,28: 253–256.[Link]
13.Yu X*, Lao Y*, Teng XL*, Li S, Zhou Y, Wang F, Guo X, Deng S, Chang Y, Wu X, Liu Z, Chen L, Lu LM, Cheng J, Li B, Su B, Jiang J, Li HB#, Huang C#, Yi J#, Zou Q#,SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation,Nat Commun.,2018,9(1):3157.[Link]
14.Tong J, Flavell RA#, Li HB#,RNA m6A modification and its function in diseases,Frontiers of Medicine,2018,Aug;12(4):481-489.[Link]
15.Yu X*, Teng XL*, Wang F*, Zheng Y*, Qu G, Zhou Y, Hu Z, Wu Z, Chang Y, Chen L, Li HB, Su B, Lu L#, Liu Z#, Sun SC#, Zou Q#,Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome,J Exp Med,2018,3;215(9):2463-2476.[Link]
16.Liu Y, Li HB, Flavell RA,cGAS activation in phased droplets,Cell Research,2018,2018(0):1-2.[Link]
17.Zhang X, Flavell RA#, Li HB#,hnRNPA2B1: a nuclear DNA sensor in antiviral immunity,Cell Research,2019,0:1–2.[Link]
18.Wang J, Flavell RA#, Li HB#,Antiviral immunity: a link to bile acids.,Cell Research,2019,29(3): 177-178.[Link]
19.Gao YM, Vasic R, Song YB, Teng R, Liu CY, Gbyli R, Biancon G, Nelakanti R, Lobben K, Kudo E, Liu W, Ardasheva A, Fu XY, Wang XM, Joshi P, Lee V, Dura B, Viero G, Iwasaki A, Fan R, Xiao A, Flavell RA.*, Li HB*, Tebaldi T*, Halene S*,m6A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development.,Immunity,2020,52, 1-15.[Link]
Yajuan Hao, Ph.D. Associate Professor Email: haoyajuan@sjtu.edu.cn Yongbo Liu, Ph.D. Associate Professor Email: Yongbo.Liu@shsmu.edu.cn Kaiqiong Mao, M.S. Administrative Assistant Email: kaiqiong.mao@sjtu.edu.cn Mei Yang, M.S. Lab Manager Email: yangmei@shsmu.edu.cn Yatao Zhou, M.S. Technician Email: zhouyatao@sjtu.edu.cn Sheng Hu, M.S. Technician Email: husheng946@163.com Ting Zhang, Ph.D. Postdoctoral Fellow(2017) Email: zhangting@shsmu.edu.cn Zhibin Yu, Ph.D. Postdoctoral Fellow(2018) Email: yuzhibin@sjtu.edu.cn Xingli Zhang, Ph.D. Postdoctoral Fellow(2019) Email: zhangxingli@shsmu.edu.cn Jing Zhou, Ph.D. Postdoctoral Fellow(2019) Email: jingzhou@shsmu.edu.cn Xuefei Wang, Ph.D. Postdoctoral Fellow (2019) Email: wangxf@shsmu.edu.cn Jingyu Li, Ph.D. Postdoctoral Fellow(2020) Email: lijy@shsmu.edu.cn Shan Miao Ph.D. student (2019) Email: shan.miao@sjtu.edu.cn Yinong Chao Ph.D. student (2017) Email: ValentChao@126.com Huifang Chen M.S. student (2018) Email: chenhuifang@sjtu.edu.cn