Jiang, H.*; Tiche, S. J*.; He, C*. J.; Liu, J.; Bian, F.; Jedoui, M.; Forgo, B.; Islam, M. T.; Zhao, M.; Emengo, P.; et al. Restoring mitochondrial quantity and quality to reverse the Warburg effect and drive neuroblastoma differentiation. Proceedings of the National Academy of Sciences 2025, 122 (36), e2502483122.(*Co-first authors) |
Jiang, H.; Greathouse, R. L.; Tiche, S. J.; Zhao, M.; He, B.; Li, Y.; Li, A. M.; Forgo, B.; Yip, M.; Li, A.; et al. Mitochondrial uncoupling induces epigenome remodeling and promotes differentiation in neuroblastoma. Cancer Research 2023, 83 (2), 181–194. |
Jiang, H. *; Macorano, A. *; Xing, E. *; Jedoui, M. *; Mohammed, S.; Lee, V.; Cheng, J.; McDonough, L.; Cheng, X.; Ye, J.; et al. Discovery of Niclosamide Analogs with Potent Mitochondrial Uncoupling Activity and Reduced Mitochondrial Inhibition–Associated Toxicity. ACS Medicinal Chemistry Letters 2026, 17(3):642–648.(*Co-first authors)
|
Jiang, H.; He, C. J.; Li, A. M.; He, B.; Li, Y.; Zhou, M. N.; Ye, J. Mitochondrial uncoupling inhibits reductive carboxylation in cancer cells. Mol Cancer Res 2023, 21(10):1010–1016.
|
Zhao, M. *; Zhang, D. *; Jiang, H. *; Kuganesan, N.; Natarajan, S.; Pu, L.; Thakkar, K. N.; Zhao, H.; Le, Q. T.; Giaccia, A. J. The RNA demethylase FTO promotes glutamine metabolism in clear cell renal cell carcinoma through the regulation of SLC1A5. Science Advances 2025, 11 (25), eadv2417. (*Co-first authors) |
Liu, P. *; Chen, W. *; Jiang, H. *; Huang, H.; Liu, L.; Fang, F.; Li, L.; Feng, X.; Liu, D.; Dalal, R. Differential Effects of SARM1 Inhibition in Traumatic Glaucoma and EAE Optic Neuropathies. Molecular Therapy-Nucleic Acids 2023, 32, 181–194.(*Co-first authors)
|
Liu, Y.; Jiang, H.; Liu, J.; Stuani, L.; Merchant, M. J.; Jager, A.; Koladiya, A.; Chang, T.-C.; Domizi, P.; Sarno, J. DHODH as a Targetable Metabolic Achilles' Heel for chemo-resistant B-ALL. Blood Journal 2026, Blood. 2025029264.
|
Jiang, H.; Ye, J. The Warburg effect: The hacked mitochondrial-nuclear communication in cancer. Seminars in Cancer Biology 2025, 112, 93–111.
|
| Jiang, H.; Jedoui, M.; Ye, J. The Warburg effect drives dedifferentiation through epigenetic reprogramming. Cancer Biol Med 2024, 20 (12). |
Jiang, H.; Li, A. M.; Ye, J. The magic bullet: Niclosamide. Frontiers in Oncology 2022, 12. |
Yang, F.; Zhang, D.; Jiang, H.; Ye, J.; Zhang, L.; Bagley, S. J.; Winkler, J.; Gong, Y.; Fan, Y. Small-molecule toosendanin reverses macrophage-mediated immunosuppression to overcome glioblastoma resistance to immunotherapy. Science Translational Medicine 2023, 15 (683), eabq3558. |
Jiang, H.; Bian, F.; Zhou, H.; Wang, X.; Wang, K.; Mai, K.; He, G. Nutrient sensing and metabolic changes after methionine deprivation in primary muscle cells of turbot (Scophthalmus maximus L.). J Nutr Biochem 2017, 50, 74–82. |
Li, A. M.; He, B.; Karagiannis, D.; Li, Y.; Jiang, H.; Srinivasan, P.; Ramirez, Y.; Zhou, M.-N.; Curtis, C.; Gruber, J. J.; et al. Serine starvation silences estrogen receptor signaling through histone hypoacetylation. Proceedings of the National Academy of Sciences 2023, 120 (38), e2302489120.
|