Precision Metabolic Profiling and Discovery

JIANG Hao-wen







JIANG Hao-wen

Associate Researcher  

✉️    hwjiang@shsmu.edu.cn

💼     Room A910, Research Building

🔍    The main research directions are centered on mitochondrial metabolic regulation and neuroprotective mechanisms. Specifically, these directions focus on mitochondrial uncoupling, hibernation-associated metabolic adaptation, and broader metabolism-regulatory processes, integrating metabolomics, stable isotope tracing, mitochondrial functional assays, and animal models to systematically investigate how metabolic remodeling regulates neuronal cell fate, injury responses, and repair processes. Building on these studies, the research aims to develop metabolism-based neuroprotective intervention strategies, optimize novel mitochondrial uncoupler candidates, and identify additional metabolic interventions capable of inducing or enhancing protective metabolic states, thereby evaluating their translational potential for neural injury and neurodegenerative diseases.


  EDUCATION

2014 - 2019 Ph.D. Ocean University of China
2009 - 2013 B.S. Shanghai Ocean University


  RESEARCH & WORK EXPERIENCE

2026 - present Associate Investigator SANS Institute for Neuroscience & Vision Research, Shanghai Jiao Tong University School of Medicine
2019- 2025 Postdoctoral Fellow Stanford University School of Medicine


  RESEARCH & REPRESENTATIVE PUBLICATIONS

Jiang, H.*; Tiche, S. J*.; He, C*. J.; Liu, J.; Bian, F.; Jedoui, M.; Forgo, B.; Islam, M. T.; Zhao, M.; Emengo, P.; et al. Restoring mitochondrial quantity and quality to reverse the Warburg effect and drive neuroblastoma differentiation. Proceedings of the National Academy of Sciences 2025, 122 (36), e2502483122.(*Co-first authors)

Jiang, H.; Greathouse, R. L.; Tiche, S. J.; Zhao, M.; He, B.; Li, Y.; Li, A. M.; Forgo, B.; Yip, M.; Li, A.; et al. Mitochondrial uncoupling induces epigenome remodeling and promotes differentiation in neuroblastoma. Cancer Research 2023, 83 (2), 181–194. 

Jiang, H. *; Macorano, A. *; Xing, E. *; Jedoui, M. *; Mohammed, S.; Lee, V.; Cheng, J.; McDonough, L.; Cheng, X.; Ye, J.; et al. Discovery of Niclosamide Analogs with Potent Mitochondrial Uncoupling Activity and Reduced Mitochondrial Inhibition–Associated Toxicity. ACS Medicinal Chemistry Letters 2026, 17(3):642–648.(*Co-first authors) 

Jiang, H.; He, C. J.; Li, A. M.; He, B.; Li, Y.; Zhou, M. N.; Ye, J. Mitochondrial uncoupling inhibits reductive carboxylation in cancer cells. Mol Cancer Res 2023, 21(10):1010–1016.

Zhao, M. *; Zhang, D. *; Jiang, H. *; Kuganesan, N.; Natarajan, S.; Pu, L.; Thakkar, K. N.; Zhao, H.; Le, Q. T.; Giaccia, A. J. The RNA demethylase FTO promotes glutamine metabolism in clear cell renal cell carcinoma through the regulation of SLC1A5. Science Advances 2025, 11 (25), eadv2417. (*Co-first authors)

Liu, P. *; Chen, W. *; Jiang, H. *; Huang, H.; Liu, L.; Fang, F.; Li, L.; Feng, X.; Liu, D.; Dalal, R. Differential Effects of SARM1 Inhibition in Traumatic Glaucoma and EAE Optic Neuropathies. Molecular Therapy-Nucleic Acids 2023, 32, 181–194.*Co-first authors)

Liu, Y.; Jiang, H.; Liu, J.; Stuani, L.; Merchant, M. J.; Jager, A.; Koladiya, A.; Chang, T.-C.; Domizi, P.; Sarno, J. DHODH as a Targetable Metabolic Achilles' Heel for chemo-resistant B-ALL. Blood Journal 2026, Blood. 2025029264.

Jiang, H.; Ye, J. The Warburg effect: The hacked mitochondrial-nuclear communication in cancer. Seminars in Cancer Biology 2025, 112, 93–111.

Jiang, H.; Jedoui, M.; Ye, J. The Warburg effect drives dedifferentiation through epigenetic reprogramming. Cancer Biol Med 2024, 20 (12).

Jiang, H.; Li, A. M.; Ye, J. The magic bullet: Niclosamide. Frontiers in Oncology 2022, 12.

Yang, F.; Zhang, D.; Jiang, H.; Ye, J.; Zhang, L.; Bagley, S. J.; Winkler, J.; Gong, Y.; Fan, Y. Small-molecule toosendanin reverses macrophage-mediated immunosuppression to overcome glioblastoma resistance to immunotherapy. Science Translational Medicine 2023, 15 (683), eabq3558.

Jiang, H.; Bian, F.; Zhou, H.; Wang, X.; Wang, K.; Mai, K.; He, G. Nutrient sensing and metabolic changes after methionine deprivation in primary muscle cells of turbot (Scophthalmus maximus L.). J Nutr Biochem 2017, 50, 74–82.

Li, A. M.; He, B.; Karagiannis, D.; Li, Y.; Jiang, H.; Srinivasan, P.; Ramirez, Y.; Zhou, M.-N.; Curtis, C.; Gruber, J. J.; et al. Serine starvation silences estrogen receptor signaling through histone hypoacetylation. Proceedings of the National Academy of Sciences 2023, 120 (38), e2302489120.


  RESEARCH & WORK EXPERIENCE

National Natural Science Foundation of China, Young Scientists Fund Category C

2026.01 - 2028.12

Principal Investigator

ongoing


  RESEARCH & TALENT PROGRAM

Shanghai Magnolia Talent Program

Young Talent Project

     

信息来源:技术与创新汇聚中心 发布日期:2026-04-21