学术带头人
基本信息：
姓名：吴皓
职称：教授，博士生导师，主任医师
邮箱：wuhao@@sh9hospital.org.cn
个人简介：
上海交通大学医学院附属第九人民医院院长，中华耳鼻咽喉头颈外科杂志总编辑，中华医学会耳鼻咽喉头颈外科分会前任主任委员，国家卫健委听力筛查专家组组长。
长期从事耳科学和听觉医学的临床、教学和科研工作，建立了基于听觉功能保留与重建的耳神经颅底外科体系，累计完成耳神经颅底手术超过5000例。牵头建立我国新生儿听力筛查技术规范并在全国推广，创新多项人工听觉植入新技术，研发国产听觉脑干植入装置，先天性耳聋的听觉重建效果大幅度提高。系统研究遗传和环境交互作用在耳蜗病变中的致病机制，通过病毒载体改造、基因编辑工具开发和内耳给药进路创新，实现内耳不同类型细胞的靶向转染和基因编辑，为耳聋基因治疗药物进入临床奠定基础。
先后以项目负责人承担科技部“973”项目、国家重点研发计划和国家自然科学基金重点项目。作为第一完成人获得国家科技进步奖二等奖1项（2018）、教育部科学技术进步奖一等奖2项（2011、2019）、上海市科技进步奖一等奖1项（2014）。
代表性论文：
1. Baoyi Feng*, Tingting Dong*, Xinxu Song*, Xiaofei Zheng, Chenxi Jin, Zhenzhe Cheng, Yiqing Zhang, Wenjie Zhang, Dehong Yu#, Yong Tao#, Hao Wu#. Personalized Porous Gelatin Methacryloyl Sustained-release Nicotinamide Protects Against Noise-induced Hearing Loss. Advanced Science. 2024,11(12):e2305682.
2. Qixuan Wang*, Xueling Wang*, Tao Yang, Lu Yang, Huihui Liu, Yihang Zheng, Guixian Jiang, Hongchao Liu, Chenhui Huang, Juan Chen, Zhentao Wang, Zhaoyan Wang, Wei Zhao, Jiannan Lin, Xuejie Zhang, Junbo Shi, Kun Han, Xingyu Le, Yan Ren, Yun Li, Yingying Hong, Wentao Shi, Dongqi Cui, Minfei Qian, Jun Xu, Xiaofei Zheng, Yunge Gao, Chen Li, James Lin, Zhiwu Huang#, Hao Wu#. A common variant in AAK1 reduces risk of noise-induced hearing loss. National Science Review. 2023,10(7):nwad080.
3. Huihui Liu*, Hongchao Liu*, Longhao Wang*, Lei Song*, Guixian Jiang*, Qing Lu, Tao Yang, Hu Peng, Ruijie Cai, Xingle Zhao, Ting Zhao, Hao Wu#. Cochlear transcript diversity and its role in auditory functions implied by an otoferlin short isoform. Nature Communications. 2023,14(1):3085.
4. Huihui Liu*, Hongchao Liu*, Longhao Wang*, Lei Song*, Guixian Jiang*, Qing Lu, Tao Yang, Hu Peng, Ruijie Cai, Xingle Zhao, Ting Zhao, Hao Wu#. Cochlear transcript diversity and its role in auditory functions implied by an otoferlin short isoform. Nature Communications. 2023,14(1):3085.
5. Yuanyuan Xue*, Yong Tao*, Xing Wang*, Xueling Wang, Yilai Shu, Yuanhua Liu, Wen Kang, Sifan Chen, Zhenzhe Cheng, Boou Yan, Yanwei Xie, Lanting Bi, Haitao Jia, Jinhui Li, Qingquan Xiao, Liying Chen, Xuan Yao, Linyu Sh, Hui Yang#, Hao Wu#. RNA base editing therapy cures hearing loss induced by OTOF gene mutation. MolecularTherapy. 2023,31(12):3520-3530.
6. Yong Tao*, Xiaoyi Liu*, Liu Yang*, Cenfeng Chu, Fangzhi Tan, Zehua Yu, Junzi Ke, Xiang Li, Xiaofei Zheng, Xingle Zhao, Jieyu Qi, Chao-Po Lin, Renjie Chai#, Guisheng Zhong#, Hao Wu#. AAV-ie-K558R mediated cochlear gene therapy and hair cell regeneration. Signal Transduction and Targeted Therapy. 2022,7(1):109.
7. Lu Xue*, Weiwei He*, Yi Zhang*, Zhigang Wang, Hongsai Chen, Zhe Chen, Weidong Zhu, Dongmei Liu, Huan Jia, Yi Jiang#, Zhaoyan Wang#, Hao Wu#. Origins of biallelic inactivation of NF2 in Neurofibromatosis Type 2. Neuro-Oncology. 2022,24(6):903-913.
8. Ying Chen*, Zhili Wang*, Yi Jiang, Yun Lin, Xueling Wang, Zhentao Wang, Zheng Tang, Yi Wang, Jimei Wang, Yunge Gao, Wentao Shi, Zhiwu Huang, Yun Li, Junbo Shi, Xue Wang, Qiongfei Yu, Yunqian Ma, Jin Zhou, Tao Yang#, Hao Wu#. Biallelic p.V37I variant in GJB2 is associated with increasing incidence of hearing loss with age. Genetics in Medicine. 2022,24(4):915-923.
9. Yunfeng Hua*#, Xu Ding*, Haoyu Wang*, Fangfang Wang*, Yan Lu, Jakob Neef, Yunge Gao, Tobias Moser#, Hao Wu#. Electron Microscopic Reconstruction of Neural Circuitry in the Cochlea. Cell Reports. 2021,34(1):108551.
10. Jiayi Gu*, Yuming Chen*, Ling Tong, Xueling Wang#, Dehong Yu#, Hao Wu#. Astaxanthin-loaded polymer-lipid hybrid nanoparticles (ATX-LPN): assessment of potential otoprotective effects.Journal Of Nanobiotechnology. 2020,18(1):53.
