学术带头人
基本信息：
姓名：吴皓
职称：教授，博士生导师，主任医师
邮箱：wuhao@@sh9hospital.org.cn
个人简介：
上海市耳鼻疾病转化医学重点实验室主任、上海交通大学医学院耳科学研究所所长、中华耳鼻咽喉头颈外科杂志总编辑,第十二届中华医学会耳鼻咽喉头颈外科分会主任委员，《中华耳鼻咽喉头颈外科杂志》主编，《中华耳鼻咽喉头颈外科杂志》副主编，《中华耳科学杂志》副主编。
担任科技部重点研发项目首席科学家并长期致力于耳科学基础与临床转化研究，先后主持卫生部卫生公益性行业科研专项、国家自然科学基金重点项目和上海市重点研究项目等国家及省部级科研项目。曾获2019年教育部科学技术进步奖一等奖、2018年国家科技进步奖二等奖，2014年上海市科技进步奖一等奖、2013年教育部科学技术进步奖一等奖、2013年上海医学科技奖一等奖，并被评为2019上海市科技精英、2010年上海市领军人才、2010年上海市优秀学科带头人等。
代表性论文：
1. Huihui Liu*, Shangfeng Liao*, Xiaowei Li*, Li Song*, Mu-Ming Poo, Jing Zhao, Weijun Zhou, Ruijie Cai, Meijian Wang, Xiaotong Ma, Shaohui Lin, Xingle Zhao, Ningyuan Zhu, Yuanwei Zhang, Junpu Mei, Lei Song, Lijian Zhao, Sidi Liu, Ying Chen, Hao Wu#. Cochlear nucleus spatial transcriptomes of normal and hearing loss mice reveal a critical role of Spp1 in bushy cells. Cell research. 2026, 36(7):531-550.
2. Baoyi Feng*, Tingting Dong*, Xinxu Song*, Xiaofei Zheng, Chenxi Jin, Zhenzhe Cheng, Yiqing Zhang, Wenjie Zhang, Dehong Yu#, Yong Tao#, Hao Wu#. Personalized Porous Gelatin Methacryloyl Sustained-release Nicotinamide Protects Against Noise-induced Hearing Loss. Advanced Science. 2024,11(12):e2305682.
3. Qixuan Wang*, Xueling Wang*, Tao Yang, Lu Yang, Huihui Liu, Yihang Zheng, Guixian Jiang, Hongchao Liu, Chenhui Huang, Juan Chen, Zhentao Wang, Zhaoyan Wang, Wei Zhao, Jiannan Lin, Xuejie Zhang, Junbo Shi, Kun Han, Xingyu Le, Yan Ren, Yun Li, Yingying Hong, Wentao Shi, Dongqi Cui, Minfei Qian, Jun Xu, Xiaofei Zheng, Yunge Gao, Chen Li, James Lin, Zhiwu Huang#, Hao Wu#. A common variant in AAK1 reduces risk of noise-induced hearing loss. National Science Review. 2023,10(7):nwad080.
4. Huihui Liu*, Hongchao Liu*, Longhao Wang*, Lei Song*, Guixian Jiang*, Qing Lu, Tao Yang, Hu Peng, Ruijie Cai, Xingle Zhao, Ting Zhao, Hao Wu#. Cochlear transcript diversity and its role in auditory functions implied by an otoferlin short isoform. Nature Communications. 2023,14(1):3085.
5. Yuanyuan Xue*, Yong Tao*, Xing Wang*, Xueling Wang, Yilai Shu, Yuanhua Liu, Wen Kang, Sifan Chen, Zhenzhe Cheng, Boou Yan, Yanwei Xie, Lanting Bi, Haitao Jia, Jinhui Li, Qingquan Xiao, Liying Chen, Xuan Yao, Linyu Sh, Hui Yang#, Hao Wu#. RNA base editing therapy cures hearing loss induced by OTOF gene mutation. MolecularTherapy. 2023,31(12):3520-3530.
6. Yong Tao*, Xiaoyi Liu*, Liu Yang*, Cenfeng Chu, Fangzhi Tan, Zehua Yu, Junzi Ke, Xiang Li, Xiaofei Zheng, Xingle Zhao, Jieyu Qi, Chao-Po Lin, Renjie Chai#, Guisheng Zhong#, Hao Wu#. AAV-ie-K558R mediated cochlear gene therapy and hair cell regeneration. Signal Transduction and Targeted Therapy. 2022,7(1):109.
7. Lu Xue*, Weiwei He*, Yi Zhang*, Zhigang Wang, Hongsai Chen, Zhe Chen, Weidong Zhu, Dongmei Liu, Huan Jia, Yi Jiang#, Zhaoyan Wang#, Hao Wu#. Origins of biallelic inactivation of NF2 in Neurofibromatosis Type 2. Neuro-Oncology. 2022,24(6):903-913.
8. Ying Chen*, Zhili Wang*, Yi Jiang, Yun Lin, Xueling Wang, Zhentao Wang, Zheng Tang, Yi Wang, Jimei Wang, Yunge Gao, Wentao Shi, Zhiwu Huang, Yun Li, Junbo Shi, Xue Wang, Qiongfei Yu, Yunqian Ma, Jin Zhou, Tao Yang#, Hao Wu#. Biallelic p.V37I variant in GJB2 is associated with increasing incidence of hearing loss with age. Genetics in Medicine. 2022,24(4):915-923.
9. Yunfeng Hua*#, Xu Ding*, Haoyu Wang*, Fangfang Wang*, Yan Lu, Jakob Neef, Yunge Gao, Tobias Moser#, Hao Wu#. Electron Microscopic Reconstruction of Neural Circuitry in the Cochlea. Cell Reports. 2021,34(1):108551.
10. Jiayi Gu*, Yuming Chen*, Ling Tong, Xueling Wang#, Dehong Yu#, Hao Wu#. Astaxanthin-loaded polymer-lipid hybrid nanoparticles (ATX-LPN): assessment of potential otoprotective effects.Journal Of Nanobiotechnology. 2020,18(1):53.
