Name: TANG Qiannan
Email: qiannan.tang@sjtu.edu.cn
Tel: 021-54591053
Research Field:
1. The biological function of left-handed Z-NAs
The research in the laboratory focuses on the unconventional left-handed nucleic acid, namely Z-nucleic acids (Z-NAs). Viral infection leads to the formation of Z-NAs and subsequently trigger cell death, moreover,
endogenous Z-NAs have the potential to activate innate immune responses and inflammation which result in autoimmune diseases such as AGS and IBD or the neurodegenerative diseases.
The scientific questions we aim to explore include:
1.1 The function of Z-NAs in anti-viral immunity;
1.2 The function of Z-NAs in homeostasis or diseases;
1.3 Development of therapeutics against multiple diseases by modulating Z-NAs.
2. Anti-tumor Immunity
Application of cutting-edge technology in stem cell research on tumor immunotherapy.
Personal Introduction:
2006–2010: Shandong University, Bachelor’s Degree
2010–2016: Institute of Biophysics, Chinese Academy of Sciences, Ph.D.
2017–2020: MRC Weatherall Institute of Molecular Medicine, University of Oxford, Postdoctoral Fellow
2020–2022: Li Ka Shing Faculty of Medicine, The University of Hong Kong, Postdoctoral Fellow
2023–present: Shanghai Jiao Tong University School of Medicine / Shanghai Institute of Immunology, Principal Investigator (PI)
Scientific Research Projects:
PI Start-up Fund, Shanghai Jiao Tong University School of Medicine / Shanghai Institute of Immunology, 2023
General Program of the National Natural Science Foundation of China, 2023 (Grant Number: 32370918)
Shanghai Public Health Outstanding Young Scholar Program, 2023, (Grant Number: GWVI-11.2-YQ45)
Shanghai Rising-Star Program, 2024, (Grant Number: 24QA2707700)
Publications
Qiannan Tang, Rachel E. Rigby, George R. Young, Astrid Korning Hvidt, Tanja Davis, Tiong Kit Tan, Anne Bridgeman, Alain R. Townsend, George Kassiotis, Jan Rehwinkel, Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS- dependent type I interferon responses, Immunity, 2021, 54(9): 1961-1975.e5.
Qiannan Tang, Xinlu Wang, Guangxia Gao, The Short Form of the Zinc Finger Antiviral Protein Inhibits Influenza A Virus Protein Expression and Is Antagonized by the Virus-Encoded NS1, Journal of Virology, 2017, 2(91): e01909-16.
Qiannan Tang, Z-nucleic acids: Uncovering the functions from past to present, European Journal of Immunology, 2022, 52(11): 1700-1711.
Le Qin, Yuanbin Cui, Tingjie Yuan, Dongmei Chen, Ruocong Zhao, Shanglin Li, Zhiwu Jiang, Qiting Wu, Youguo Long, Suna Wang, Zhaoyang Tang, Huixia Pan, Xiaoping Li, Wei Wei, Jie Yang, Xuequn Luo, Zhenfeng Zhang, Qiannan Tang, Pentao Liu, Robert Weinkove, Yao Yao, Dajiang Qin, Jean Paul Thiery, Peng Li, Co-expression of a PD-L1-specific chimeric switch receptor augments the efficacy and persistence of CAR T cells via the CD70-CD27 axis, Nature Communications, 2022, 13(1): 6051.
Shanglin Li; Ruocong Zhao; Diwei Zheng; Le Qin; Yuanbin Cui; Yao Li; Zhiwu Jiang; Mengjun Zhong; Jingxuan Shi; Ming Li; Xindong Wang; Zhaoyang Tang; Qiting Wu; Youguo Long; Duo Hu; Suna Wang; Yao Yao; Shuang Liu; Li-Hua Yang; Zhenfeng Zhang; Qiannan Tang; Pentao Liu; Yangqiu Li; Peng Li; DAP10 integration in CAR-T cells enhances the killing of heterogeneous tumors by harnessing endogenous NKG2D, Molecular Therapy - Oncolytics, 2022, 26: 15-26
Yuanbin Cui, Tingjie Yuan,Ying Wang, Di Diwei Zheng, Le Qin, Shanglin Li, Zhiwu Jiang, Shouheng Lin, Wenjing Guo, Zhaoduan Liang, Yi Li, Yao Yao, Xingguo Liu, Qiannan Tang, Hai-Yan Tu, Xu-Chao Zhang, Zhaoyang Tang, Yan-Lai Tang, Libin Huang, Xuequn Luo, Nathalie Wong, Zhenfeng Zhang, Dajiang Qin, Jean Paul Thiery, Kailin Xu, Peng Li. T lymphocytes expressing the switchable chimeric Fc receptor CD64 exhibit augmented persistence and antitumor activity. Cell Reports, 2023, Jul25; 42(7):112797.