Lab Leader:Tang Qiannan
Lab Name:Laboratory of Nucleic Acid Biology and Immunotherapy
Lab Info：Our laboratory investigates the biological functions of left-handed Z-nucleic acids (Z-NAs), an unconventional nucleic acid structure implicated in immunity and disease pathogenesis. Viral infection induces Z-NAs formation to trigger cell death, while endogenous Z-NAs can activate innate immune responses and inflammation, with dysregulation contributing to autoimmune diseases such as Aicardi-Goutières syndrome (AGS) and inflammatory bowel disease (IBD), as well as neurodegenerative disorders. Our research aims to elucidate the function of Z-NAs in anti-viral immunity, explore their roles in immune homeostasis and disease pathology, and develop therapeutics against multiple diseases by modulating Z-NA pathways. In parallel, we apply stem cell technologies to advance tumor immunotherapy, bridging fundamental insights in nucleic acid biology with translational strategies for cancer treatment.
Lab Members:
| Name | Title | |
| Tang Qiannan | Research Professor | qiannan.tang@sjtu.edu.cn |
| Shao Jing | Assistant Research Fellow | xiaojingtongzhi@163.com |
| Wang Wenfang | Laboratory Technician | wwfang@shsmu.edu.cn |
| Zhang Xue | 2023 Direct-Entry Ph.D. Student | zhangxue-olaf@sjtu.edu.cn |
| Wang Ting | 2025 Integrated Master-Ph.D. Student | wantingre@sjtu.edu.cn |
| Liao Caijiang | 2023 Master's student | caijiang.liao@sjtu.edu.cn |
| Peng Xuelan | 2024 Direct-Entry Ph.D. Student | pengxuelan@sjtu.edu.cn |
| Xie Jiajun | 2024 Master's student | xiejiajun@sjtu.edu.cn |
LabPhoto:
