Lab Leader:WenxiangZhang

Lab Name: Laboratory oftranscriptional regulation mechanisms of adaptive immunity

Lab Info：Building on its existing research achievements, the research group is committed to addressing key questions in tumorigenesis and immune regulation. Leveraging the scientific and clinical resources of Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Immunology, and Ruijin Hospital, the group plans to investigate transcriptional regulatory mechanisms of genes in depth from molecular and biochemical perspectives through interdisciplinary approaches and the development of diverse research and analytical methods, with the ultimate goal of pursuing clinical translation:

1. To further explore the molecular mechanisms by which the transcription factor FOXP3 regulates Treg cells, as well as its dynamic regulatory roles in the tumor microenvironment and autoimmune diseases.

2. To investigate the regulatory mechanisms of other core transcription factors across the immune system, uncover novel and more complex regulatory patterns, and strive to identify universal regulatory principles.

3. To elucidate the functions of microsatellite sequences in the genome in immune regulation and genome stability, examine their associations with specific diseases, and conduct analyses integrated with epidemiological data.

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