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Chen Li

Date:2019-12-09 show:

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 Chen Li, Ph.D., Professor

 Director of Proteomics and Metabolomics Core,

 The Center for Single-Cell Omics (CSCOmics), School of Public Health,

 Shanghai Jiao Tong University School of Medicine

 Address: 227 South Chong-Qing South Road, HuangPu District, Shanghai, China

 Email: cli@sjtu.edu.cn; cli@shsmu.edu.cn


Prof.  Li obtained Ph.D. in biochemistry and molecular biology from Shanghai  Institute of Biochemistry and Cell Biology (SIBCB), Shanghai Institutes  for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS). From  2006 to 2020, she worked in SIBCB, SIBS, CAS. During the period, she was  appointed as associate professor. In March 2020, she joined in the  Center for Single-Cell Omics, School of Public health, Shanghai Jiao  Tong University School of Medicine as core director of proteomics and  metabolomics core.

The  research directions of Prof. Li include 1) Development and application  of cutting-edge single-cell and spatial resolution proteomic techniques.  2) The establishment and development of MS methods, and its  applications in clinical cancer research, cancer mouse models,  cardiovascular diseases, and signal transduction research; 3)  Multi-omics research on colorectal cancer, pancreatic cancer, lung  cancer.

Prof.  Li has published 24 original papers in prestigious journals,  participated in 1 international series and 1 Chinese science book, and  taken part in the applications for 27 Chinese invention patents (12  granted). As presenter, she has presided over a Foundation from National  Natural Science Foundation of China, a Shanghai Science and technology  Innovation action plan project, and a Knowledge Innovation Program of  SIBS, CAS, and. As participator, she has involved into three National  Key Basic Research Program of China (973 Program), two Major Research  Plan of National Natural Science Foundation of China, one General  Program from National Natural Science Foundation of China, one Strategic  Leading Science and Technology, CAS, and one Key Special Projects in  National Development Plan. Prof. Li has been awarded SANOFI-SIBS  Scholarship for Outstanding Young Scientist, selected into Shanghai  Science and Technology Expert Database, Pudong New Area Science and  Technology Expert Database. Prof. Li also works as a reviewer of GPB,  WJG and other journals.


Publications:(#first author, *corresponding author)

1. Li H#, Fu X#, Zhao J#, Li C#,  Li L, Xia P, Guo J, Wei W, Zeng R, Wu J*, Sun Y*, Huang L*, Wang X*.  EXOC4 Promotes Diffuse-Type Gastric Cancer Metastasis via Activating FAK  Signal. Mol Cancer Res. 2022 Jul 6;20(7):1021-1034.

2. Wu Y, Cao Y, Xu K, Zhu Y, Qiao Y, Wu Y, Chen J, Li C*, Zeng R*, Ge G*. Dynamically remodeled hepatic extracellular matrix predicts prognosis of early-stage cirrhosis. Cell Death Dis. 2021 Feb 8;12(2):163.

3. Feng L#, Sun YD#, Li C, Li YX, Chen LN, Zeng R*. Pan-cancer Network Disorders Revealed by Overall and Local Signaling Entropy. J Mol Cell Biol. 2021 Dec 6;13(9):622-635.

4. Sun Y#, Li C#,  Pang S, Yao Q, Chen L*, Li Y*, Zeng R*. Kinase-substrate edge  biomarkers provide a more accurate prognostic prediction in ER-negative  breast cancer. Genomics, Proteomics & Bioinformatics. 2020 Oct;18(5):525-538.

5. Li C#,  Sun Y#, Yu G#, Cui J#, Lou Z#, Zhang H, Huang Y, Bai C, Deng L, Liu P,  Zheng K, Wang Y, Wang Q, Li Q, Wu Q, Liu Q, Shyr Y, Li Y, Chen L, Wu J*,  Zhang W*, Zeng R*. Integrated Omics of Metastatic Colorectal Cancer. Cancer Cell. 2020 Nov 9;38(5):734-747.

6. Han J#, Yu M#, Bai Y#, Yu J#, Jin F, Li C,  Zeng R, Peng J, Li A, Song X, Li H*, Wu D*, Li L*. Elevated CXorf67  Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to  PARP Inhibitors. Cancer Cell. 2020 Dec 14;38(6):844-856.

7. Tang Y#, He Y#, Li C#  Mu W, Zou Y, Liu C, Qian S, Zhang F, Pan J, Wang Y, Huang H, Pan D,  Yang P, Mei J*, Zeng R*, Tang QQ*. RPS3A positively regulates the  mitochondrial function of human periaortic adipose tissue and is  associated with coronary artery diseases. Cell Discovery. 2018 Aug 21;4:52.

8. Zhu X, Yuan C, Tian C, Li C,  Nie F, Song X, Zeng R, Wu D, Hao X, Li L*. The plant sesquiterpene  lactone parthenoide inhibits Wnt/β-catenin signaling by blocking  synthesis of the transcriptional regulators TCF4/LEF1. J Biol Chem. 2018 Apr 6;293(14):5335-5344.

9. Li M#, Li C#,  Liu W, Liu C, Cui J, Li Q, Ni H, Yang Y, Wu C, Chen C, Xing Z, Liu X,  Zeng T, Zhao M, Chen L, Wu J*, Zeng R*, Chen L*. Dysfunction of PLA2G6  and CYP2C44 associated network signals imminent carcinogenesis from  chronic inflammation to hepatocellular carcinoma. J Mol Cell Biol. 2017 Dec 1;9(6):489-503.

10. He X#, Zhang W#, Yan C#, Nie F, Li C,  Liu X, Fei C, Li S, Song X, Jia Y, Zeng R, Wu D, Pan W*, Hao X*, Li L*.  Chemical biology reveals CARF as a positive regulator of canonical Wnt  signaling by promoting TCF/β-catenin transcriptional activity. Cell Discovery. 2017, 3, 17003.

11. Liang J#, Cao R#, Wang X, Zhang Y, Wang P, Gao H, Li C,  Yang F, Zeng R, Wei P, Li D, Li W, Yang W*. Mitochondrial PKM2  regulates oxidative stress-induced apoptosis by stabilizing Bcl2. Cell Res. 2017 Mar;27(3):329-351.

12. Li F#, Fang Z#, Zhang J#, Li C,  Liu H, Xia J, Zhu H, Guo C, Qin Z, Li F, Han X, Wang Y, Feng Y, Wang Y,  Zhang W, Wang Z, Jin Y, Sun Y, Wei W, Zeng R, Chen H, Ji  H*.Identification of TRA2B-DNAH5 fusion as a novel oncogenic driver in  human lung squamous cell carcinoma. Cell Res. 2016 Oct;26(10):1149-1164.

13. Sheng Q#, Li R#, Dai J#, Li Q, Su Z, Guo Y, Li C,  Shyr Y*, Zeng R*. Preprocessing significantly improves the  peptide/protein identification sensitivity of high-resolution  isobarically labeled tandem mass spectrometry data. Mol Cell Proteomics. 2015 Feb;14(2):405-17.

14. Fei C, Li Z, Li C,  Chen Y, Chen Z, He X, Mao L, Wang X, Zeng R, Li L*.Smurf1-mediated  Lys29-linked non-proteolytic poly-ubiquitination of Axin negatively  regulates Wnt/β-catenin signaling. Mol Cell Biol. 2013, 33(20):4095-105.

15. Wang S#, Yin J#, Chen D, Nie F, Song X, Fei C, Miao H, Jing C, Ma W, Wang L, Xie S, Li C, Zeng R, Pan W, Hao X*, Li L*. Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction. Nat Chem Biol. 2013 Sep;9(9):579-85.

16. Li C#, Ruan HQ#, Liu YS#,  Xu MJ, Dai J, Sheng QH, Tan YX, Yao ZZ, Wang HY, Wu JR, Zeng R*.  Quantitative proteomics reveal up-regulated protein expression of the  SET complex associated with hepatocellular carcinoma. J Proteome Res. 2012 Feb 3;11(2):871-85.

17. Wu C#, Wei W#, Li C, Li Q, Sheng Q, Zeng R*. J Proteome Res. Delicate analysis of post-translational modifications on Dishevelled 3. J Proteome Res. 2012 Jul 6;11(7):3829-37.

18. Liu YS#, Luo XY#, Li QR, Li H, Li C,  Ni H, Li RX, Wang R, Hu HC, Pan YJ, Chen HQ*, Zeng R*. Shotgun and  targeted proteomics reveal that pre-surgery serum levels of LRG1, SAA,  and C4BP may refine prognosis of resected squamous cell lung cancer. J Mol Cell Biol. 2012 Oct;4(5):344-7.

19. Micutkova L, Diener T, Li C,  Rogowska-Wrzesinska A, Mueck C, Huetter E, Weinberger B,  Grubeck-Loebenstein B, Roepstorff P, Zeng R, Jansen-Duerr P*.  Insulin-like growth factor binding protein-6 delays replicative  senescence of human fibroblasts. Mech Ageing Dev. 2011 Oct;132(10):468-79.

20. Sun B, Guo S, Tang Q, Li C, Zeng R, Xiong Z, Zhong C, Ding J*. Regulation of the histone acetyltransferase activity of hMOF via autoacetylation of Lys274. Cell Res. 2011 Aug;21(8):1262-6.

21. Liu Y#, Li C#,  Xing Z, Yuan X, Wu Y, Xu M, Tu K, Li Q, Wu C, Zhao M*, Zeng R*.  Proteomic mining in the dysplastic liver of WHV/c-myc mice--insights and  indicators for early hepatocarcinogenesis. FEBS J. 2010 Oct;277(19):4039-53.

22. Li C,  Hong Y, Tan YX, Ai JH, Zhou H, Li SJ, Zhang L, Xia QC, Wu JR, Wang HY*,  Zeng R*. Analysis of microdissected cells by two-dimensional LC-MS  approaches. Methods Mol Biol. 2008;428:193-208.

23. Ding Y#, Xi Y#, Chen T, Wang JY, Tao DL, Wu ZL, Li YP, Li C, Zeng R, Li L*. Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation. J Cell Biol. 2008 Sep 8;182(5):865-72.

24. Li C#, Tan YX#,  Zhou H, Ding SJ, Li SJ, Ma DJ, Man XB, Hong Y, Zhang L, Li L, Xia QC,  Wu JR, Wang HY*, Zeng R*. Proteomic analysis of hepatitis B  virus-associated hepatocellular carcinoma: Identification of potential  tumor markers. Proteomics. 2005 Mar;5(4):1125-39.

25. Li C,  Hong Y, Tan YX, Zhou H, Ai JH, Li SJ, Zhang L, Xia QC, Wu JR, Wang HY*,  Zeng R*, Accurate qualitative and quantitative proteomic analysis of  clinical hepatocellular carcinoma using laser capture microdissection  coupled with isotope-coded affinity tag and two-dimensional liquid  chromatography mass spectrometry. Mol Cell Proteomics. 2004 Apr;3(4):399-409.

26. Tu C, Li C, Chapter 13, Sample preparation; Ding S, Tang L, Li C,  Chapter 23, The application of proteomics; Editor: Zeng R, Xia Q,  Protein Chemistry and Proteomics, 1 ed. ISBN: 7-03-012401-4/Q.1331  BeiJing: China Science Publishing, 2004.4


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Core members:

-Director: Chen Li

-Technician: Lei Gu

-Technician: Qinqin Wang