Bing Su, Ph.D., Professor
Director, Shanghai Institute of Immunology
Chair, Department of Immunology and Microbiology,Shanghai Jiao Tong University School of Medicine
Director, Immune and Microbiota Related Diseases Research Center of Shanghai Institute of Immunology & Shanghai General Hospital, Shanghai JiaoTong University School of Medicine
Director,Shanghai Jiao Tong University School of Medicine-Yale University Immunometabolism Research Center (SYIRC)
KC Wong Chair Professor, Shanghai Jiao Tong University
Professor Adjunct to Department of Immunobiology, Yale University School of Medicine
The research in Dr.Su's laboratory focuses on the biology of signal transduction mediated by the intracellular protein kinase network such as the mitogen-activated protein kinase (MAPK) cascades and the mammalian target of rapamycine (mTOR) pathway in gut immune responses and in blood vessel function/development. They study the genes that encode either the serine/threonine kinases or their regulators in the kinase pathways. Their studies have revealed the roles of these kinase pathways in transducing various receptor signals and in regulating cell growth, differentiation, and apoptosis.
Education:
1991 Ph.D. Yale University
1987 M.Ph. Yale University
1984 B.S. Peking University
Work Experience:
2018-Present Director, Shanghai Jiao Tong University School of Medicine-Yale University Immunometabolism Research Center (SYIRC)
2016-Present Director, Immune and Microbiota Related Diseases Research Center of Shanghai Institute of Immunology & Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
2014-present Adjunct Professor, Department of Immunobiology and the Vascular Biology and Therapeutics Program, Yale School of Medicine
2014-Present KC Wong Endowed Chair Professor, Shanghai Jiaotong University
2014-present Adjunct Professor, Yale School of Medicine
2013-Present Professor and Chair, Department of Immunology and Microbiology, Shanghai Jiaotong University School of Medicine
2012-Present Director and Principal Investigator, Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine
2009-2012 Guest Professor, Shanghai Jiaotong University School of Medicine
2007-2014 Associate Professor (Tenure), Yale School of Medicine and Graduate School of Arts & Sciences
2006-2006 Professor with Tenure, The University of Texas, MD Anderson Cancer Center
1995-2006 Assistant, Associate, and Full Professor, The University of Texas Health Science Center
1991-1995 Postdoctoral Fellow, University of California at San Diego
Publications:
1. M Li, AS Lazorchak, X Ouyang, H Zhang, H Liu, O.A Arojo, G Qu, X Xu, X Liu, W Zhang, Q Wang, D Liu, F Li,B Su（Corresponding author）.Sin1/mTORC2 regulates B cell growth and metabolism via mTORC1 and Myc activation.Cell Mol Immunol,2019,10.1038/s41423-018-0185-x. [Link]
2. X Ouyang, Y Han, G Qu, M Li, O Arojo, H Sun, X Liu, D Liu, LChen, Q Zou, Bing Su.（Corresponding author）. Metabolic regulation of T cell development by Sin1-mTORC2 is mediated by pyruvate kinase M2 .J Mol Cell Biol,2018,11(2):93-106. [Link]
3. Xu YY, Ouyang XX, Yan LC, Zhang ML, Hu ZL, Gu JM, Fan XM, Zhang L, Zhang JF, Xue S, Chen GQ, Su B（Corresponding author）, and Liu JL..Sin1 regulates ischaemia-induced microthrombosis through integrin αIIbβ3-mediated outside-in signaling and hypoxia responses in platelet.Arteriosclerosis, Thrombosis, and Vascular Biology,2018,(in press). [Link]
4. Wu ZR, Yan LC, Liu YT, Cao L, Guo YH, Zhang Y, Yao H, Cai L, Shang HB, Rui WW, Yang G, Zhang XB, Tang H, Wang Y, Huang JY, Wei YX, Zhao WG, Su B （Corresponding author） and Wu ZB..Selective mTORC1 inhibition by lncRNA H19 via disruption of the 4E-BP1 and Raptor interaction in pituitary tumors.Nature Communications,2018,9:4624. [Link]
5. OA. Arojo, X Ouyang, D Liu, T Meng, SM. Kaech, JP. Pereira and B Su.（Corresponding author）.Active mTORC2 Signaling in Naive T Cells Suppresses Bone Marrow Homing by Inhibiting CXCR4 Expression .J Immunol,2018,201:908-915.. [Link]
6. Xuemei Fan, Conghui Wang, Panlai Shi, Wen Gao, Jianmin Gu, Yan Geng, Wenlong Yang, Ningbo Wu, Yang Wang, Yanyan Xu, Xue Chen, Lin Zhang, Kemin Wang,Bing Su（Corresponding author） and Junling Liu.Platelet MEKK3 regulates arterial thrombosis and myocardial infarct expansion in mice.Blood Adv,2018,26;2(12):1439-1448.. [Link]
7. Zepp JA, Zhao J, Liu C, Bulek K, Wu L, Chen X, Hao Y, Wang Z, Wang X, Ouyang W, Kalady MF, Carman J, Yang WP, Zhu J, Blackburn C Huang YH, Hamilton TA1,2, Su B（Corresponding author） and LiX..IL-17A-Induced PLET1 Expression Contributes to Tissue Repair and Colon Tumorigenesis.J Immuno l,2017,199(11):3849-3857. [Link]
8. Tan R, Nakajima S, Wang Q, Sun H,Xue J, Wu J, Hellwig S, Zeng X, Yates NA7, Smithgall TE, Lei M, Jiang Y, Levine AS, Su B（Corresponding author）, Lan L..Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1.Mol Cell,2017 ,65(5):818-831. [Link]
9. Wang Q, Tan R, Zhu X, Zhang Y, Tan Z, Su B（Corresponding author）, Li Y ..Oncogenic K-ras confers SAHA resistance by up-regulating HDAC6 and c-myc expression .Oncotarget,2016,7(9):10064-72. [Link]
10. Fisher OS, Deng H, Liu D, Zhang Y, Wei R, Deng Y, Zhang F, Louvi A, Turk BE, Boggon TJ, Su B.（Corresponding author）.Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex.Nat Commun,2015,6: 1-11. [Link]
11. Liu P, Gan W, Chin YR, Ogura K, Guo J, Zhang J, Wang B, Blenis J, Cantley LC, Toker A, Su B（Corresponding author）, Wei W.PtdIns (3,4,5)P3-dependent activation of the mTORC2 kinase complex.Cancer Discov,2015,5(11):1194-209. [Link]
12. Chang X, Liu F, Wang X, Lin A, Zhao H, Su B.（Corresponding author）.The kinases MEKK2 and MEKK3 regulate transforming growth factor-β-mediated helper T cell differentiation.Immunity,2011,34(2):201-12. [Link]
13. Valeria Facchinetti, Weiming Ouyang, Hua Wei, Nelyn Soto, Adam Lazorchak, Christine Gould, Carolyn Lowry, Alexandra C. Newton, Yuxin Mao, Robert Q. Miao, William C. Sessa, Jun Qin, Pumin Zhang, Su B（Corresponding author）, and Estela Jacinto. . The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J,2008, 27(14):1932-43. [Link]
14. Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, Huang Q, Qin J, Su B.（Corresponding author） .SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. . Cell, 2006, 127(1):125-37. [Link]
15. Qiaojia Hunag, Jianhua Yang, Jinke Cheng, CM Walker, Z.G. Liu, and Su B. （Corresponding author）.Differential regulation of interleukin-1 receptor and toll like receptor (TLR) signaling by MEKK3. Nature Immunology,2004,5:95-103. [Link]
16. Yang J, Lin Y, Guo Z, Borem M, Huang H, Liao, Chen Z, Liu ZG, and Su B. （Corresponding author）.Essential role of MEKK3 in TNF-induced NF-kB activation.Nature Immunology ,2001,2:620-624. [Link]
17. Su B.（First author）, Jacinto, E., Hibi, M., Kallunki, T., Karin, M., and Ben-Neriah, Y. .JNK mediates signal integration during costimulation of T lymphocytes. Cell .,1994, 77:727-736,. [Link]
