Youqiong Ye, Principal Investigator

 Shanghai Institute of Immunology

 Faculty of Basic Medicine

 Shanghai Jiao Tong University School of Medicine

 Phone: 021-63846590-776664

 Email: youqiong.ye@shsmu.edu.cn

Research Interest:

1. Tumor multi-omics data mining, identify tumor disease markers and drug targets, and explore the mechanisms of tumor occurrence and development.

2. Study the regulatory effect of hypoxia and circadian rhythm in cancer immunotherapy.

Education: 

Sep 2011–Dec 2016  Doctor of Nature Science, Biology, Tongji University, Shanghai, China

Sep 2007–Jun 2011  Bachelor of Engineering, Biological Engineering, Fuzhou University, Fuzhou, China

Research Experience: 

Sep 2016–Dec 2019  Postdoctoral Research Fellow (Bioinformatics/Cancer Genomics), The University of Texas Health Science Center at Houston, Mentor: Leng Han, Ph.D.

Professional Memberships:

Sep 2017–Present  American Association for Cancer Research, Member.

Selected Publications：

1. Ye Y.*, Zhang Z.*, Liu Y., Han L. A multi-omics perspective for quantitative trait loci. Trends in Genetics (2020). Online, 02/24/2020. IF:10.63.

2. Ye Y., Jing Y., Li L., Mills G.B., Diao L., Liu H., Han L. Sex-associated molecular differences for cancer immunotherapy. Nature Communication (2020). (In press). IF:11.88.

3. Ye Y.*, Hu Q.*, Chen H., Liang K., Yuan Y., Xiang Y., Ruan H., Zhang Z., Song A., Zhang H., Liu L., Diao L., Lou Y., Zhou B., Wang L., Zhou S., Gao J., Jonasch E., Lin S.H. et al. Characterization of hypoxia-associated molecular features to aid hypoxia-targeted therapy. Nature Metabolism (2019). 1, 431–444. (Featured as Cover Story, Included in Nature Research Collection on “Nobel Prize in Physiology or Medicine 2019”)

4. Hu Q.*, Ye Y.*, Chan L.-C., Li Y., Liang K., Lin A., Egranov S.D., Zhang Y., Xia W., Gong J., Pan Y., Chatterjee S.S., Yao J., Evans K.W., Nguyen T.K., Park P.K., Liu J., Coarfa C., Donepudi S.R. et al. Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression. Nature Immunology (2019). 20, 835–851. IF:23.53.

5. Xiang Y.*, Ye Y.*, Lou Y., Yang Y., Cai C., Zhang Z., Mills T., Chen N., Kim Y., Ozguc F.M., Diao L., Karmouty-quintana H., Xia Y., Kellems R., Chen Z., Yoo S., Shyu A., Mills G.B. & Han L. Comprehensive characterization of alternative polyadenylation in human cancer. Journal of the National Cancer Institute (2018). 110, 379–389. IF:10.2.

6. Ye Y., Xiang Y., Ozguc F.M., Kim Y., Liu C.J., Park P.K., Hu Q., Diao L., Lou Y., Lin C., Guo A.Y., Zhou B., Wang L., Chen Z., Takahashi J.S., Mills G.B., Yoo S.H. & Han L. The Genomic Landscape and Pharmacogenomic Interactions of Clock Genes in Cancer Chronotherapy. Cell Systems (2018). 6, 314-328.E2. IF:8.64. (Highlighted by preview from Cell Systems.)

7. Xiang Y.*, Ye Y.*, Zhang Z. & Han L. Maximizing the utility of cancer transcriptomic data. Trends Cancer (2018). 4, 823–837. IF: 8.89.

8. Zhang Z.*, Ye Y.*, Gong J., Ruan H., Liu C., Xiang Y., Cai C., Guo A., Ling J., Diao L., Weinstein J.N. & Han L. Global analysis of tRNA and translation factor expression reveals a dynamic landscape of translational regulation in human cancers. Communications Biology (2018). 1, 234.

9. Ye Y.*, Li M.*, Gu L., Chen X., Shi J., Zhang X. & Jiang C. Chromatin remodeling during in vivo neural stem cells differentiating to neurons in early Drosophila embryos. Cell Death and Differentiation (2017). 24, 409–420. IF:8.03.

10. Ye Y., Gu L., Chen X., Shi J., Zhang X. & Jiang C. Chromatin remodeling during the in vivo glial differentiation in early Drosophila embryos. Scientific Reports (2016). 16, 33422. IF:4.01.

11. Ye Y., Zhang Y., Hu Q., Zhang Z., Sun C., Zhou B., Wang L., Lin C., Gao J., Lou Y., Lin S.H., Diao L., Liu, H, Mills G.B., Han L. Dynamic profiling of immune features to predict immunotherapy efficacy. Cell (In review) . IF:36.22.

12. Shi L.*, Ye Y.*, Zeng L*, Shi H.*, Tiwary S., Chang G., Huse J.T., Huo L., Ma L., Ma Y., Zeng L., Zhang S., Zhu J., Han L., He C. & Huang S. YTHDF3-mediated RNA translation impacts multiple steps of breast cancer brain metastasis. Cancer Cell (In revision). IF:23.92.

13. Ye Y., Kuang X., Liang L., Zhang Y., Ma, F., Xie, Z., Su J, Peng J., Diao L., Chen X., Han L., Liu H. Small-molecule MMP2/MMP9 inhibitor SB-3CT modulates tumor immune surveillance by regulating PD-L1. Genome Medicine (In revision). IF:10.89.