Programmable RNA Editing and Therapeutics

HAN Wen-Jian







HAN Wen-jian

Associate Researcher  

✉️    hanwenjian@sjtu.edu.cn

💼     Room A910, Research Building

🔍    This platform is dedicated to the original development of programmable RNA editing and modulation technologies, integrating approaches from synthetic biology, protein engineering, and RNA base editing to establish next-generation RNA reprogramming systems, featuring gRNA-independent RNA editing technologies with high specificity and efficiency. Focusing on major disease targets, we aim to systematically advance the application of RNA editing technologies in gene therapy and clinical translation, and to develop innovative RNA therapeutic strategies with independent intellectual property.


  EDUCATION

2018 - 2021 University of Chinese Academy of Sciences Computational Biology Ph.D.
2013 - 2016 Shanghai Normal University Biochemistry and Molecular Biology M.S.
2009 - 2013 Linyi University Biological Sciences B.S.
 

  RESEARCH & WORK EXPERIENCE

2023 - 2026 Songjiang Research Institute, Shanghai Jiao Tong University School of Medicine Associate Researcher
2021- 2023 Center for Excellence in Brain Science and Intelligence Technology Postdoctoral Fellow
2016- 2018 CAS-MPG Partner Institute for Computational Biology Research Assistant

  REPRESENTATIVE PUBLICATIONS

Han W*#, Yuan B*, Fan X, Li W, Yuan Y, Zhang Y, Wang S, Shan S, Hafner M, Wang Z#, Qiu Z#. Effective in vivo RNA base editing via engineered cytidine deaminase APOBECs fused with PUF proteins. Nature Communications, 2025,16:9727. (* Co-first authors, # Corresponding authors)

Han W*, Huang W*, Wei T, Ye Y, Mao M, Wang Z. Programmable RNA base editing with a single gRNA-free enzyme. Nucleic Acids Research, 2022, 50(16): 9580-9595. (* Co-first authors)

Zhang C*, Ren M*, Han W*, Zhang Y, Huang M, Wu S, Huang J, Wang Y, Zhang Z, Yang Z. Slow development allows redundant genes to restore the fertility of rpg1, a TGMS line in Arabidopsis. The Plant journal, 2022, 109(6): 1375-1385. (* Co-first authors)

Han W, Qiu Z. Crossing the blood–brain barrier: Advances and frontiers of AAV gene therapy in central nervous system disorders. Chinese Bulletin of Life Sciences, 2026, 38(4).

Li W, Zhang S, Peng W, Shi Y, Yuan B, Yuan Y, Xue Z, Wang J, Han W, Chen Z, Shan S, Xue B, Chen J, Zhang C, Zhu S,  Tai Y, Cheng T, Qiu Z. Whole-brain in vivo base editing reverses behavioral changes in Mef2c-mutant mice. Nature Neuroscience, 2023, 27: 116-128.

Wang J, Li W, Li Z, Xue Z, Zhang Y, Yuan Y, Shi Y, Shan S, Han W, Li F, Qiu Z. Taok1 haploinsufficiency leads to autistic-like behaviors in mice via the dorsal raphe nucleus. Cell Reports, 2023, 42(9).

Sun Y, Bao Y, Han W, Song F, Shen X, Zhao J, Zuo J, Saffen D, Chen W, Wang Z, You X, Wang Y. Autoregulation of RBM10 and cross-regulation of RBM10/RBM5 via alternative splicing-coupled nonsense-mediated decay. Nucleic Acids Research, 2017, 45(14): 8524-8540.

Xu X, Wang B, Lou Y, Han W, Lu J, Li D, Li L, Zhu J, Yang Z. Magnesium Transporter 5 plays an important role in Mg transport for male gametophyte development in Arabidopsis. The Plant Journal,2015, 84(5):925-936.     

信息来源:The Hub 发布日期:2026-04-22