Personal Introduction

Dr Cheng is the principal investigator at Shanghai Jiao Tong University School of Medicine. She has engaged in the development of artificial intelligence (AI) and molecular simulation algorithms, and recently has focused on the glycan-based drug design. Dr Cheng has developed a series of precise AI algorithms for glycan-based drug design, e.g., DeepGlycanSite, which won the "Tianhe Star" Excellent Application Award. She also designed multiple high-precision biological nanopores for glycan sequencing, providing new technologies for glycomics research. She revealed the molecular mechanisms of various glycans regulating GPCR targets, offering insights into the functional study of glycans. To date, Dr Cheng has published over 60 SCI papers, cited more than 10,000 times by others. Recently, as a (co-)corresponding author, she has published papers in top journals, includingNat Commun, J Am Chem Soc, Mol CellandPNAS. She has received awards such as the Shanghai Oriental Talents Youth and the Outstanding Member of the Youth Innovation Promotion Association of the Chinese Academy of Sciences. Additionally, she serves as a council member of the Chinese Society for Glycobiology and a young council member of the Artificial Intelligence Pharmacy Special Committee of the Shanghai Pharmaceutical Association.

Publications:

1. He X^#, Zhao L^#, Tian Y^#, Li R, Chu Q, Gu Z, Zheng M, Wang Y, Li S, Jiang H, Jiang Y, Wen L*, Wang D*,Cheng X*. Highly accurate carbohydrate-binding site prediction with DeepGlycanSite.Nat Commun, 2024, 15:5163

2. Yao G^#, Tian Y^#, Ke W^#, Fang J, Ma S, Li T,Cheng X*, Xia B*, Wen L*, Gao Z*. Direct identification of complex glycans via a highly sensitive engineered nanopore.J Am Chem Soc, 2024, 146:13356

3. Zhao L, Wei F, He X, Dai A, Yang D, Jiang H, Wen L*,Cheng X*. Identification of a carbohydrate recognition motif of purinergic receptors.eLife, 2023, 12:e85449

4. Xia B^#,*, Fang J^#, Ma S^#, Ma M^#, Yao G, Li T,Cheng X*, Wen L*, Gao Z*. Mapping the acetylamino and carboxyl groups on glycans by engineered α-hemolysin nanopores.J Am Chem Soc, 2023, 145:18812

5. He X, You C, Jiang H, Jiang Y*, Xu HE*,Cheng X*. AlphaFold2 versus experimental structures: evaluation on G protein-coupled receptors.Acta Pharmacol Sin, 2022, 44(1): 1

6. Duan J^#, Xu P^#,Cheng X^#, Mao C^#, Croll T, He X, Shi J, Luan X, Yin W, You E, Liu Q, Zhang S, Jiang H, Zhang Y, Jiang Y, Xu HE*. Structures of full-length glycoprotein hormone receptor signalling complexes.Nature, 2021, 598(7882): 688

7. Xu P^#, Huang S^#, Mao C^#, Krumm BE^#, Zhou E, Tan Tan, Huang H, Liu Y, Shen D, Jiang Y, Yu X, Jiang H, Melcher K, Roth B*,Cheng X*, Zhang Y*, Xu HE*. Structures of the human dopamine D3 receptor-Gi complexes.Mol Cell, 2021, 81(6): 1147

8. Cong Z^#, Zhou F^#, Zhang C^#, Zou X^#, Zhang H, Wang Y, Zhou Q, Cai X, Liu Q, Li J, Shao L, Mao C, Wang W, Wu J, Xia T, Zhao L, Jiang H, Zhang Y, Xu HE,Cheng X*, Yang D*, Wang MW*. Constitutive signal bias mediated by the human GHRHR splice variant 1.PNAS, 2021, 118(40): e2106606118

9. X Wang#; X Cheng#; L Zhao#; Y Wang; C Ye; X Zou; A Dai; Z Cong; J Chen; Q Zhou; T Xia; H Jiang; EH Xu*; D Yang*; MW Wang*; Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2, PNAS, 2021, 118(32): e2101279118（Co-first author）

10. Xu P^#, Huang S^#, Zhang H^#, Mao C^#, Zhou X^#,Cheng X^#, Simon I, Shen D, Yen H, Robinson C, Harpsøe K, Svensson B, Guo J, Jiang H, Gloriam D, Melcher K, Jiang Y*, Zhang Y*, Xu HE*. Structural insights into the lipid and ligand regulation of serotonin receptors.Nature, 2021, 592(7854): 469