Medicinal Chemistry and Bioinformatics Center
Medicinal Chemistry and Bioinformatics Center

undefined

ZHUANG Youwen

Ph. D, Professor

School of Medicine

Shanghai Jiao Tong University

Tel: 021-63846590-776452

Email: youwen_zhuang@sjtu.edu.cn

Personal Introduction

Youwen Zhuang,Professor and Doctoral Supervisor at Shanghai Jiao Tong University School of Medicine. His research primarily focuses on elucidating the molecular pharmacological and signaling mechanisms of neurotransmitter GPCRs, along with rational drug design. The GPCRs of particular interest inhis work include those crucial for the onset and progression of neuropsychiatric disorders such as Parkinson’s disease, schizophrenia, depression, and chronic pain.Professor Zhuang has published19papers in top-tier journals, including four papers inCell, and others inNeuron,Nat Chem Biol,PNAS, Cell Res, etc. One of theseCell papers was selected as the cover story, and another was chosen as a featured article and‘Best of Cell 2023’. His research has been supported by NSFC, National Key R&D Program, Science and Technology Commission of Shanghai Municipality,etc. He has been recognized by the Youth Talent Support Program of China Association for Science and Technology and the Youth Innovation Promotion Association of the Chinese Academy of Sciences.The awards and honorsheachieved include MIT Technology Review Innovators Under 35 China, First Prize in Shanghai Natural Science Award, and the Sanofi Outstanding Young Scientist Award, etc.

Education

2014 – 2020 Shanghai Institute of Materia Medica, CAS Ph. D.

2018 – 2019 Van Andel Institute, USA Visiting Scholar

2010 – 2014 Southwest University, China B.S.

Positions and Employment

2008 China Pharmacology University, BS；

2014 University of Chinese Academy of Sciences, Ph.D；

Professional Experience

2024 – Now Shanghai Jiao Tong University PI/ Professor

2021– 2024 Shanghai Institute of Materia Medica, CAS Associate Professor

2021– 2024 Shanghai Institute of Materia Medica, CAS Associate Professor

Research Field:

Pharmacology, G protein-coupled receptors, Drug design and discovery

Publications (# First author, * Corresponding author):

  1. Zhuang, Y.#,*, Wang, Y.#, He, B.#, He, X.#, Zhou, X. E., Guo, S., Rao, Q., Yang, J., Liu, J., Zhou, Q., Wang, X., Liu, M., Jiang, X., Yang, D., Jiang, H., Shen, J., Melcher, K., Chen, H., Jiang, Y., Cheng, X., Wang, M.W.*, Xie, X.*, Xu, H.E. *. Molecular recognition of morphine and fentanyl by the human μ-opioid receptor.Cell, 185(23), 4361-4375(2022).(Featured article; Best of Cell, 2023)

  2. Zhuang, Y.#, Xu, P.#, Mao, C.#, Wang, L.#, Krumm, B.#, Zhou, X. E.#, Huang, S., Liu, H., Cheng, X., Huang, X. P., Shen, D. D., Xu, T., Liu, Y. F., Wang, Y., Guo, J., Jiang, Y., Jiang, H., Melcher, K., Roth, B. L.*, Zhang, Y.*, Zhang, C.*, Xu, H.E. *. Structural insights into the human D1 and D2 dopamine receptor signaling complexes. Cell. 184(4), 931-942(2021). (Cover Story)

  3. Wang, Y.#,Zhuang, Y.#, *, DiBerto, J. F.#, Zhou, X. E., Schmitz, G. P., Yuan, Q., Jain, M. K., Liu, W., Melcher, K., Jiang, Y., Roth, B. L.*, Xu, H.E. *. Structures of the entire human opioid receptor family.Cell, 186(2), 413-427(2023). (ESI Highly Cited)

  4. Xing, C.#,Zhuang, Y.#, Xu, T. H.#, Feng, Z.#, Zhou, X. E., Chen, M., Wang, L., Meng, X., Xue, Y., Wang, J., Liu, H., McGuire, T. F., Zhao, G., Melcher, K., Zhang, C.*, Xu, H.E.*, Xie, X. Q*. Cryo-EM structure of the human cannabinoid receptor CB2-Gi signaling complex.Cell, 180(4), 645-654(2020).

  5. 5.Wang, Y. #, Liu, W. #, Xu, Y., He, X., Yuan, Q., Luo, P., Fan, W., Zhu, J., Zhang, X., Cheng, X., Jiang, Y., Xu, H.E. *, Zhuang, Y. *. Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins. Nat Chem Biol, 19(11), 1351-1360 (2023).

  6. Fan,W. #, Xu,Y. #, He, X. #, Luo, P., Zhu, J.,Li, J., Wang, R., Yuan, Q., Wu, K., Hu, W.,Zhao, Y., Xu, S., Cheng, X., Wang, Y.*,Xu, H.E. *,Zhuang, Y.*. Molecular basis for the activation of PAF receptor by PAF. Cell Rep, 43(7), 114422 (2024).

  7. Wang, Y., Xu, Y., Wang, Y., Zhang, J., Chen, L., He, X., Fan, W., Wu, K., Hu, W., Cheng, X.,Yang, G., Xu, H.E. *,Zhuang, Y.*,Sun, S.*. Selective ligand recognition and activation of somatostatin receptors SSTR1 and SSTR3. PNAS, 121(41), p.e2400298121 (2024).

  8. Fan, L.,Zhuang, Y. #, Wu, H., Li, H., Xu, Y., Wang, Y., He, L., Wang, Shishan, Chen, Z., Cheng, J. *,Xu, H.E. *, Wang, Sheng*. Structural basis of psychedelic LSD recognition at dopamine D1 receptor. Neuron, 112(19), 3295-3310 (2024).

  9. Zhuang, Y.#, Krumm, B.#, Zhang, H.#, Zhou, X. E., Wang, Y., Huang, X. P., Liu, Y., Cheng, X., Jiang, Y., Jiang, H., Zhang, C., Yi, W., Roth, B. L.*, Zhang, Y.*, Xu, H.E. *. Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor. Cell Res, 31(5), 593-596 (2021).

  10. Zhuang, Y.#, Wang, L.#, Guo, J., Sun, D., Wang, Y., Liu, W., Xu, H.E. *. and Zhang, C. *. Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2.Nat Commun, 13, 1054 (2022).

  11. Zhuang, Y.#, Liu, H.#, Zhou, X. E., Kumar Verma, R., de Waal, P. W., Jang, W., Xu, T. H., Wang, L., Meng, X., Zhao, G., Kang, Y., Melcher, K., Fan, H., Lambert, N. A., Xu, H.E.*, Zhang, C. *. Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling. Nat Commun, 11, 885(2020).

  12. Liu, Q#, Yang, D#,Zhuang, Y.#, Croll, T. I., Cai, X., Dai, A., He, X., Duan, J., Yin, W., Ye, C., Zhou, F., Wu, B., Zhao, Q., Xu, H.E.*, Wang, M.W.*, Jiang, Y*. Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor.Nat Chem Biol, 17(12), 1238-1244 (2021).

  13. Xu, P. #, Huang, S. #, Krumm, B.E. #,Zhuang, Y. #, Mao, C. #, Zhang, Y., Wang, Y., Huang, X.P., Liu, Y.F., He, X., Li, H., Yin, W., Jiang, Y., Zhang, Y. *, Roth, B.L. *, Xu, H.E. *. Structural genomics of the human dopamine receptor system.Cell Res, 33, 604-616(2023).(Featured article)

  14. Wang, Y.#, Guo, S.#,Zhuang, Y.#, Yun, Y.#, Xu, P.#, He, X., Guo, J., Yin, W., Xu, H. E. *, Xie, X.*, Jiang, Y*. Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor.Nat Commun, 12, 5064 (2021).

  15. Luo, P., Xin, W., Guo, S., Li, X., Zhang, Q., Xu, Y.,He, X., Wang Y., Fang, W., Yuan, Q., Wu, K., Hu, W.,Zhuang, Y., Xu, H.E.,Xie, X. Structural insights into the agonist activity of the nonpeptide modulator JR14a on C3aR. Cell Discov, 11(1), 7 (2025).

    16. Duan, J.#, Shen, D.D.#, Zhou, X.E.#, Bi, P.#, Liu, Q.F., Tan, Y.X.,Zhuang, Y., Zhang, H. B., Xu, P. Y., Huang, S. J., Ma, S. S., He, X. H., Melcher, K., Zhang, Y. *, Xu, H.E. *, Jiang, Y *. Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy.Nat Commun, 11, 4121 (2020).

  16. Shi, Y., Ma, H.,Zhuang, Y., Wang, X. X., Jiang, Y., Xu, H.E. C10ORF12 modulates PRC2 histone methyltransferase activity and H3K27me3 levels. Acta Pharmacol Sin, 40, 1457–1465 (2019).

  17. Dutka, P., Mukherjee, S., Gao, X., Kang, Y., de Waal, P.W., Wang, L.,Zhuang, Y., Melcher, K., Zhang, C., Xu, H.E., Kossiakoff, A. A. Development of “Plug and Play” Fiducial Marks for Structural Studies of GPCR Signaling Complexes by Single-Particle Cryo-EM. Structure, 27, 1-13 (2019).

  18. Shi, Y, Wang, X, Zhuang, Y., Jiang, Y., Melcher, K., Xu, H.E. Structure of the PRC2 complex and application to drug discovery. Acta Pharmacol Sin, 38 (7), 963-976(2017).

No. 227 South Chongqing  Road, Shanghai, China   200025   021-63846590

Shanghai ICP No. 0505204  Shanghai Public Network Security No. 31009102000047

Copyright © 2017 Shanghai Jiao Tong University School of Medicine