Personal Introduction

Dr. Xiaoling Gao obtained her Ph.D. in pharmaceutics from School of Pharmacy, Fudan University in 2007, following which she joined the Shanghai Jiao Tong University School of Medicine. Her team has been focusing on engineering biomimetic nanocarriers for targeted delivery of biomacromolecular therapeutics, translational nanotherapeutics for precision treatment of brain diseases, and mapping and controlling the intracerebral fate of nanocarriers to improve efficacy and safety. Her work has been published in leading journals like Nature Nanotechnology and Nature Communications, and highlighted in Science Translational Medicine. She holds over 30 PCT/Chinese patents, with 14 granted, and one Alzheimer's intervention therapy is in clinical trials.

Publications: 10 representative publications preferably in recent 10 years.

• Wang, A., Huang, J., Ji, M., Huang, Y., Chen, L., Peng, Y., Wang, C., Shi, K., Zhang, C., Yu, R., Jiang, G., Sun, X., Chen, H., Song, Q., and Gao, X. (2025). Membrane budding inspired biomimetic nanocarrier delivers brain‐derived neurotrophic factor to improve AD cognition. Adv. Funct. Mater. 35, e2416572.

• Gao, J., Song, Q., Gu, X., Jiang, G., Huang, J., Tang, Y., Yu, R., Wang, A., Huang, Y., Zheng, G., Chen, H., and Gao, X. (2024). Intracerebral fate of organic and inorganic nanoparticles is dependent on microglial extracellular vesicle function. Nat. Nanotechnol. 19, 376-386.

• Huang, M., Zheng, M., Song, Q., Ma, X., Zhang, Q., Chen, H., Jiang, G., Zhou, S., Chen, H., Wang, G., Dai, C., Li, S., Li, P., Wang, H., Zhang, A., Huang, Y., Chen, J., and Gao, X. (2024). Comparative proteomics inspired self‐stimulated release hydrogel reinforces the therapeutic effects of MSC‐EVs on alzheimer's disease. Adv. Mater. 36, e2311420.

• Huang, J., Fu, Y., Wang, A., Shi, K., Peng, Y., Yi, Y., Yu, R., Gao, J., Feng, J., Jiang, G., Song, Q., Jiang, J., Chen, H., and Gao, X. (2024). Brain delivery of protein therapeutics by cell matrix‐inspired biomimetic nanocarrier. Adv. Mater. 36, e2405323.

• Zhang, Q., Song, Q., Yu, R., Wang, A., Jiang, G., Huang, Y., Chen, J., Xu, J., Wang, D., Chen, H., and Gao, X. (2023). Nano‐brake halts mitochondrial dysfunction cascade to alleviate neuropathology and rescue alzheimer's cognitive deficits. Adv. Sci. 10, e2204596.

• Xie, X., Song, Q., Dai, C., Cui, S., Tang, R., Li, S., Chang, J., Li, P., Wang, J., Li, J., Gao, C., Chen, H., Chen, S., Ren, R., Gao, X., and Wang, G. (2023). Clinical safety and efficacy of allogenic human adipose mesenchymal stromal cells-derived exosomes in patients with mild to moderate alzheimer’s disease: a phase i/II clinical trial. Gen. Psychiat. 36, e101143.

• Zhang, Q., Song, Q., Gu, X., Zheng, M., Wang, A., Jiang, G., Huang, M., Chen, H., Qiu, Y., Bo, B., Tong, S., Shao, R., Li, B., Wang, G., Wang, H., Hu, Y., Chen, H., and Gao, X. (2021). Multifunctional nanostructure RAP‐RL rescues alzheimer's cognitive deficits through remodeling the neurovascular unit. Adv. Sci. 8, e2001918.

• Chen, L., Song, Q., Chen, Y., Meng, S., Zheng, M., Huang, J., Zhang, Q., Jiang, J., Feng, J., Chen, H., Jiang, G., and Gao, X. (2020). Tailored reconstituted lipoprotein for site-specific and mitochondria-targeted cyclosporine a delivery to treat traumatic brain injury. ACS Nano 14, 6636-6648.

• Jiang, G., Chen, H., Huang, J., Song, Q., Chen, Y., Gu, X., Jiang, Z., Huang, Y., Lin, Y., Feng, J., Jiang, J., Bao, Y., Zheng, G., Chen, J., Chen, H., and Gao, X. (2020). Tailored lipoprotein‐like miRNA delivery nanostructure suppresses glioma stemness and drug resistance through receptor‐stimulated macropinocytosis. Adv. Sci. 7, e1903290.

• Huang, J., Jiang, G., Song, Q., Gu, X., Hu, M., Wang, X., Song, H., Chen, L., Lin, Y., Jiang, D., Chen, J., Feng, J., Qiu, Y., Jiang, J., Jiang, X., Chen, H., and Gao, X. (2017). Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to ras-activated glioblastoma cells via macropinocytosis. Nat. Commun. 8, 15144.