Department of Biochemistry and Molecular Cell Biology
Department of Biochemistry and Molecular Cell Biology

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HOU Zhaoyuan

Email: houzy@sjtu.edu.cn

Tel: 021-63846590-776714

Laboratory of Gene Expression Regulation

Research Field: Gene Expression and Regulation

Personal Introduction

Obtained his doctoral degree from the Department of Molecular and Cellular Physiology, College of Medicine, University of Cincinnati in August 2003 and did his postdoctoral training at College of Medicine, University of Pennsylvania. Joined the in the Department of Biochemistry and Molecular Cell Biology, Shanghai Jiaotong University School of Medicine as a principal investigator (PI) and as the group leader of the Gene Expression and Regulation laboratory in February 2011. His major interest is to explore the molecular network of genes regulating tumorigenesis and metastasis.

1. Current positions

  • February 2011-Present: Professor, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

2. Postdoctoral training

  • May 2005-August 2009: Ruth L. Kirschstein NIH fellow, The Wistar Institute, Philadelphia, USA.

  • July 2003-May 2005: Postdoctoral fellow, The University of Pennsylvania, Philadelphia, USA.

3. Education

  • June 1998-August 2003: Ph.D. degree in Physiology, College of Medicine, The University of Cincinnati, Ohio, USA.

  • Sept. 1992-July 1995: Master's degree in Entomology, The Institute of Zoology, Academia Sinica, Beijing, China.

  • Sept. 1988-July 1992: Bachelor's degree in biological sciences, The Shandong Normal University, Jinan, China.

Ongoing Research Projects

  • Molecular mechanism of deubiquitinating enzyme USP29 promoting breast cancer cell metastasis (PI, Nature Science Foundation of China, Grant No.: 81872131, 2019.1-2022.12)

  • The LIM protein Ajuba in adipogenesis (PI, Nature Science Foundation of China, Grant No.: 31671415, 2017.1-2020.12)

Publications

  1. Shi L(#), Yang Y(#), Li M, Li C, Zhou Z, Tang G, Wu L, Yao Y, Shen X, Hou Z(*), Jia H(*). LncRNA IFITM4P promotes immune escape by up-regulating PD-L1 via dual mechanism in oral carcinogenesis. Mol Ther, 2022 Apr 6, 30(4):1564-1577.

  2. Zhang Q, Zhang Y, Zhang J, Zhang D, Li M, Yan H, Zhang H, Song L, Wang J, Hou Z(*), Yang Y(*), Zou X(*). p66α Suppresses Breast Cancer Cell Growth and Migration by Acting as Co-Activator of p53. Cells, 2021 Dec 20,10(12):3593.

  3. Han Yan, Qi Li, Mengying Li, Xiuqun Zou, Ningning Bai, Zichao Yu, Jie Zhang, Dan Zhang, Qun Zhang, Jiamin Wang, Hao Jia(*), Yingjie Wu(*), Zhaoyuan Hou(*). Ajuba functions as a co-activator of C/EBPβ to induce expression of PPARγ and C/EBPα during adipogenesis. Molecular and Cellular Endocrinology, 2022, 539:111485.

  4. Hao Jia(#)(*), Yuquan Yang(#), Mengying Li(#), Yimin Chu, Huan Song, Jie Zhang, Dan Zhang, Qun Zhang, Ying Xu, Jiamin Wang, Hong Xu, Xiuqun Zou, Haixia Peng(*), Zhaoyuan Hou(*). Snail enhances arginine synthesis by inhibiting ubiquitination-mediated degradation of ASS1. EMBO Reports, 2021, 22: e51780.

  5. Jinrui Xu(#), Yuquan Yang(#), Zhaoyuan Hou(*), Hao Jia(*), Yujiong Wang(*). TRPV2-spike protein interaction mediates the entry of SARS-CoV-2 into macrophages in febrile conditions. Theranostics, 2021, 11(15):7379-7390.

  6. Zhang P, Zhang Z, Fu Y, Zhang Y, Washburn MP, Florens L, Wu M, Huang C, Hou Z(*), Mohan M(*). K63-linked ubiquitination of DYRK1A by TRAF2 alleviates Sprouty 2-mediated degradation of EGFR. Cell Death Dis, 2021, 12(6):608.

  7. Hao Jia(#)(*), Ao Zhang(#), Yuquan Yang, Yaqi Cui, Jianrong Xu, Hewei Jiang, Shengce Tao, Dawei Zhang, Heping Zeng, Zhaoyuan Hou(*), Jijun Feng(*). A graphene oxide coated tapered microfiber acting as a super-sensor for rapid detection of SARS-CoV-2. Lab Chip, 2021, 21:2398-2406.

  8. Qian W(#), Li Q(#), Wu X, Li W, Li Q, Zhang J, Li M, Zhang D, Zhao H, Zou X, Jia H, Zhang L(*), Yang XD(*), Hou Z(*). Deubiquitinase USP29 promotes gastric cancer cell migration by cooperating with phosphatase SCP1 to stabilize Snail protein. Oncogene, 2020, 39:6802-6815.

  9. Jia H, Peng H, Hou Z. Ajuba: An emerging signal transducer in oncogenesis. Pharmacol Res, 2020, 151:104546. (review)

  10. Bosen Zhang(#), Liwei Song(#), Jiali Cai, Lei Li, Hong Xu, Mengying Li, Jiamin Wang, Minmin Shi, Hao Chen1(*), Hao Jia(*), and Zhaoyuan Hou(*).The LIM protein Ajuba/SP1 complex forms a feed forward loop to induce SP1 target genes and promote pancreatic cancer cell proliferation. J Exp Clin Cancer Res, 2019, 38(1):205.

  11. Beihui Xu(#), Qi Li(#), Ning Chen, Chunxiao Zhu, Qingrong Meng, Kasirajan Ayyanathan6 Wenli Qian, Hao Jia, Jiamin Wang(*), Peihua Ni(*), Zhaoyuan Hou(*). The LIM protein Ajuba recruits DBC1 and CBP/p300 to acetylate ERα and enhances ERα target gene expression in breast cancer cells. Nucleic Acids Res, 2019, 47(5):2322-2335.

  12. 1Yihong Zhang(#), Xiuqun Zou(#), Wenli Qian, Xiaoling Weng, Lin Zhang, Liang Zhang, Shuang Wang, Xuan Cao, Li Ma, Gang Wei(*), Yingjie Wu(*), Zhaoyuan Hou(*). Enhanced PAPSS2/VCAN sulfation axis is essential for Snail-mediated breast cancer cell migration and metastasis. Cell Death Differ, 2019, 26:565-579.

  13. Yingying Wang(#), Xiaoling Weng(#), Luoyang Wang(#), Mingang Hao, Yue Li, Lidan Hou, Yu Liang, Tianqi Wu, Mengfei Yao, Guowen Lin, Yiwei Jiang, Guohui Fu, Zhaoyuan Hou(*), Xiangjun Meng(*), Jinsong Lu(*), and Jianhua Wang(*). HIC1 deletion promotes breast cancer progression by activating tumor cell/fibroblast crosstalk. J Clin Invest, 2018, 128(12):5235-5250.

  14. Jia, H.(#); Song, L.(#); Cong, Q.; Wang, J.; Xu, H.; Chu, Y.; Li, Q.;Zhang, Y.; Zou, X.; Zhang, C.; Chin, Y. E.; Zhang, X.; Li, Z.; Zhu, K.; Wang,B.; Peng, H.(*); Zhaoyuan Hou(*). The LIM protein AJUBA promotes colorectal cancer cell survival through suppression of JAK1/STAT1/IFIT2 network , Oncogene, 2017, 36(19): 2655-2666.

  15. Wang, Xiong-jun (#); Qiao, Yunbo(#) ; Xiao, Minzhe M.; Wang, Lingbo; Chen, Jun; Lv, Wenjian; Xu, Li; Li, Yan; Wang, Yumei; Tan, Ming-dian; Huang, Chao; Li, Jinsong; Zhao, Ting C.; Zhaoyuan Hou (*); Jing, Naihe (*) ; Chin, Y. Eugene(*) , Opposing Roles of Acetylation and Phosphorylation in LIFR-Dependent Self-Renewal Growth Signaling in Mouse Embryonic Stem Cells , Cell Rep, 2017, 18(4):933-946.

  16. Liu, Chao (#); Wang, Jiamin(#) ; Yuan, Xiaoyuan; Qian, Wenli; Zhang, Bosen; Shi, Minmin; Xie, Junjie; Shen, Baiyong; Xu, Hong (*);Chen, Hao(*); Zhaoyuan Hou(*), Long noncoding RNA uc.345 promotes tumorigenesis of pancreatic cancer by upregulation of hnRNPL expression, Oncotarget, 2016, 7(44): 71556-71566.

  17. Li Q (#); H Peng(#) ; H Fan; X Zou; Q Liu; Y Zhang; H Xu; Y Chu; C Wang; K Ayyanathan; FJ Rauscher(*) ; K Zhang (*);Zhaoyuan Hou(*), The LIM protein Ajuba promotes adipogenesis by enhancing PPARγ and p300/CBP interaction, Cell Death Differ, 2016, 23(1): 158-168.

  18. Hongyan Fan (#); Weibing Dong (#); Qi Li; Xiuqun Zou; Yihong Zhang; Jiamin Wang; Shengxian Li; Wei Liu; Ying Dong; Haipeng Sun (*); Zhaoyuan Hou(*), Ajuba Preferentially Binds LXRα/RXRγ Heterodimer to Enhance LXR Target Gene Expression in Liver Cells, Molecular Endocrinology, 2015, 29(11):1608-1618.

  19. Chen Jiangzhi (#); Xu Hong(#); Zou Xiuqun; Wang Jiamin; Zhu Yi; Chen Hao; Shen Baiyong; Deng Xiaxing; Zhou Aiwu; Chin Y. Eugene; Rauscher Frank J.Ⅲ; Peng Chenghong (*); Zhaoyuan Hou(*), Snail Recruits Ring1B to Mediate Transcriptional Repression and Cell Migration in Pancreatic Cancer Cells, Cancer Research, 2014, 74(16): 4353-4363.

  20. Peihua Ni (#), Hong Xu (#), Changqiang Chen,  Jiayi Wang, Xiangfan Liu,  Yiqun Hu,  Qishi Fan, Zhaoyuan Hou(*), Yang Lu(*).  Serum starvation induces DRAM expression in liver cancer cells via histone modifications within its promoter locus. PLOS ONE, 2012, 0050502.

  21. Zhaoyuan Hou(#), Hongzhuang Peng, David E. White, Pu Wang, Paul M. Lieberman, Thanos Halazonetis, Frank J. Rauscher Ⅲ(*). 14-3-3 binding sites in the snail protein are essential for snail-mediated transcriptional repression and epithelial-mesenchymal differentiation, Cancer Research, 2010, 70(11): 4385-4393.

  22. Zhaoyuan Hou(#), Hongzhuang Peng, David E. White, Dmitri G. Negorev, Gerd G. Maul, Yunfeng Feng, Gregory D. Longmore, Samuel Waxman, Arthur Zelent, Frank J. Rauscher Ⅲ(*). LIM protein Ajuba functions as a nuclear receptor corepressor and negatively regulates retinoic acid signaling, Proc Natl Acad Sci U S A, 2010, 107(7): 2938-2943.

  23. Zhaoyuan Hou(#), Hongzhuang Peng, Kasirajan Ayyanathan, Kaiping Yan, Ellen Langer, Gregory D. Longmore, Frank J. Rauscher Ⅲ(*). The LIM protein AJUBA recruits protein arginine methyltransferase 5 to mediate SNAIL-dependent transcriptional repression. Molecular and Cellular Biology, 2008, 28(10): 3198-3207.

  24. Zhaoyuan Hou(#), Sunil Srivastava, Meenakshi J. Mistry, Matthew P. Herbst, Jason P. Bailey, Nelson D. Horseman. Two tandemly linked GAS elements in the promoter of glycosylation-dependent cell adhesion molecule 1 (GlyCAM 1) gene synergistically respond to prolactin in mouse mammary epithelial cells. Mol Endocrinol, 2003, 17:1910-1920.

  25. Zhaoyuan Hou(#), Bailey JP, Vomachka AJ, Matsuda M, Lockefeer JA, Horseman ND  Glycosylation-dependent cell adhesion molecule 1 is induced by prolactin and suppressed by progesterone in mammary epithelium. Endocrinology, 2000, 141(11): 4278-4283.

  26. Fan G, Sun L, Shan P, Zhang X, Huan J, Zhang X, Li D, Wang T, Wei T, Zhang X, Gu X, Yao L, Xuan Y, Zhaoyuan Hou, Cui Y, Cao L, Li X, Zhang S, Wang C. Loss of KLF14 triggers centrosome amplification and tumorigenesis. Nat Commun, 2015, 6:8450.

  27. Ren YH, Liu KJ, Wang M, Yu YN, Yang K, Chen Q, Yu B, Wang W, Li QW, Wang J, Zhaoyuan Hou, Fang JY, Yeh ET, Yang J, Yi J. De-SUMOylation of FOXC2 by SENP3 promotes the epithelial-mesenchymal transition in gastric cancer cells. Oncotarget, 2014, 5(16):7093-7104.

  28. Peng H, Talebzadeh-Farrooji M, Osborne MJ, Prokop JW, McDonald PC, Karar J, Zhaoyuan Hou, He M, Kebebew E, Orntoft T, Herlyn M, Caton AJ, Fredericks W, Malkowicz B, Paterno CS, Carolin AS, Speicher DW, Skordalakes E, Huang Q, Dedhar S, Borden KL, Rauscher FJ 3rd. LIMD2 is a small LIM-only protein overexpressed in metastatic lesions that regulates cell motility and tumor progression by directly binding to and activating the integrin-linked kinase. Cancer Res, 2014, 74(5):1390-1403.

  29. Ellen M. Langer, Yungfeng Feng, Zhaoyuan Hou, Frank J. Rauscher III, Kristen L. Kroll, Gregory D. Longmore. AJUBA LIM proteins are SNAIL co-repressors required for neural crest development in Xenopus. Developmental Cell, 2008, 14(3):424-436.

  30. Kasirajan Ayyanathan, Hongzhuang Peng, Zhaoyuan Hou, William J. Fredericks, Rakesh K. Goyal, Ellen M. Langer, Gregory D. Longmore, Frank J. Rauscher, III. The Ajuba LIM protein is co-repressor for SNAG domain mediated repression and participate in nucleo-cytoplasmic shuttling. Cancer Research, 2007, 67(19):9097-9106.

  31. Ping La, Angela Desmond, Zhaoyuan Hou, Albert C. Silva, Robert W. Schnepp and Xianxin Hua. Tumor suppressor menin: the essential role of nuclear localization signal domains in coordinating gene expression. Oncogene, 2006, 25(25):3537-3546.

  32. Robert W. Schnepp, Zhaoyuan Hou, Haoren Wang, Clark Petersen, Albert Silva, Hisao Masai and Xianxin Hua. Functional Interaction between Tumor Suppressor Menin and Activator of S-Phase Kinase. Cancer Research, 2004, 64, 6791-6796.

  33. Ping La, Albert C. Silva, Zhaoyuan Hou, Haoren Wang, Robert W. Schnepp, Nieng Yan, Yigong Shi, and Xianxin Hua. Direct Binding of DNA by Tumor Suppressor Menin. J Biol Chem, 2004, 279(47):49045-49054.

  34. Manabu Matsuda, Tatsuhiko Imaoka, Archie J. Vomachka, Gary A. Gudelsky, Zhaoyuan Hou, Meenakshi Mistry, Jason P. Bailey, Kathryn M. Nieport, Diego J. Walther, Michael Bader, and Nelson D. Horseman. Serotonin Regulates Mammary Gland Development via an Autocrine-Paracrine Loop. Dev Cell, 2004, 6(2):193-203.

  35. Sunil Srivastava, Manabu Matsuda, Zhaoyuan Hou, Jason P. Bailey, Riko Kitazawa, Matthew P. Herbst, and Nelson D. Horseman. Receptor  activator of NF-kB ligand (RANKL) induction via Jak2 and Stat5a in mammary epithelial cells.  J Biol Chem, 2003, 278(46): 46171-46178.

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