Personal Introduction

Liu Junling, recipient of the National Science Fund for Distinguished Young Scholars, Distinguished Professor of Shanghai Jiao Tong University and Distinguished Professor of Shanghai. In 2001, he graduated from Peking University School of Medicine with a Ph.D. in medicinal chemistry. After that, he engaged in postdoctoral training in the United States. In September 2008, he returned to China and served as the Principal Investigator at the Shanghai Jiao Tong University School of Medicine. From 2012 to 2020, he served as the deputy dean of the Shanghai Jiao Tong University School of Basic Medicine. Professor Liu Junling has long been engaged in the molecular mechanism and translational research of Thrombosis and Hemostasis. He has successively obtained over 9 key competitive projects with a total funding of more than 30 million yuan, and won the Ministry of Education New Century Excellent Talent and Shanghai Pujiang Talent projects. He has published more than 80 research papers in international journals such as Circulation, Cell Metabolism, Blood, Hepatology, JCI, Nat Commun, etc. He won the first prize of the Ministry of Education's Science and Technology Progress Award and the second prize of the National Science and Technology Progress Award. Currently, he is the deputy editor and editorial board member of several journals, the vice chairman of the Vascular Medicine Special Committee of the Chinese Pathophysiology Society and the Chinese Physiological Society Thrombosis and Hemostasis Society.

Publications

1. Xue Chen , Yanyan Xu, Qidi Chen , Heng Zhang , Yu Zeng, Yan Geng, Lei Shen , Fubin Li ,Lei Chen , Guo-Qiang Chen , Chuanxin Huang , Junling Liu#. The phosphatase PTEN links platelets with immune regulatory functions of mouse T follicular helper cells. NATURE COMMUNICATIONS  2022 13:2762. https://doi.org/10.1038/s41467-022-30444-y.

2. Nan Ding*, Kang Wang*, Haojie Jiang, Mina Yang, Lin Zhang, Xuemei Fan, Qiang Zou, Jianxiu Yu, Hui Dong, Shuqun Cheng#, Yanyan Xu#, Junling Liu#. AGK regulates the progression to NASH by affecting mitochondria complex I function. Theranostics. 2022; 12(7): 3237-3250. doi: 10.7150/thno.69826.

3. Qidi Chen, Min Xin, Lingjun Wang, Lin Li, Yingzhi Shen, Yan Geng, Haojie Jiang, Yang Wang, Lin Zhang, Yanyan Xu,Yu Hou, Junling Liu#, and Xuemei Fan. Inhibition of LDHA to induce eEF2 release enhances thrombocytopoiesis. Blood. 12 MAY 2022 , VOLUME 139, NUMBER 19.

4. Jiang H, Yu Z, Ding N, Yang M, Zhang L, Fan X, Zhou Y, Zou Q, Hou J, Zheng J, Zhang L, Xu Y, Liu J#. The role of AGK in thrombocytopoiesis and possible therapeutic strategies.Blood. 2020 Jul 2;136(1):119-129. doi: 10.1182/blood.2019003851.Blood. 2020. PMID: 32202634

5. Xu Y, Jiang H, Li L, Chen F, Liu Y, Zhou M, Wang J, Jiang J, Li X, Fan X, Zhang L, Zhang J, Qiu J, Wu Y, Fang C, Sun H, Liu J#. Branched-Chain Amino Acid Catabolism Promotes Thrombosis Risk by Enhancing Tropomodulin-3 Propionylation in Platelets.  Circulation. 2020 Jul 7;142(1):49-64. doi: 10.1161/CIRCULATIONAHA.119.043581. Epub 2020 Mar 23.Circulation. 2020. PMID: 32200651

6. Hu Z, Qu G, Yu X, Jiang H, Teng XL, Ding L, Hu Q, Guo X, Zhou Y, Wang F, Li HB, Chen L, Jiang J, Su B, Liu J#, Zou Q. Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells. Cell Metab. 2019 Jun 11. pii: S1550-4131(19)30256-6. doi: 10.1016/j.cmet.2019.05.016. [Epub ahead of print]

7. Wang C, Cheng Y, Zhang X, Li N, Zhang L, Wang S, Tong X, Xu Y, Chen GQ, Cheng S, Fan , Liu J#. Vacuolar Protein Sorting 33B Is a Tumor Suppressor in Hepatocarcinogenesis. Hepatology. 2018 Dec;68(6):2239-2253.

8. Xu Y, Ouyang X, Yan L, Zhang M, Hu Z, Gu J, Fan X, Zhang L, Zhang J, Xue S, Chen G, Su B, Liu J#. Sin1 (Stress-Activated Protein Kinase-Interacting Protein)Regulates Ischemia-Induced Microthrombosis Through Integrin αIIbβ3-Mediated Outside-In Signaling and Hypoxia Responses in Platelets. Arterioscler Thromb Vasc Biol. 2018 Dec;38(12):2793-2805.

9. Fan Xuemei, Wang Conghui, Shi Panlai, Gao Wen, Gu Jianmin, Geng Yan, Yang Wenlong, Wu Ningbo, Wang Yang, Xu Yanyan, Chen Xue, Zhang Lin, Wang Kemin, Su Bin, Liu Junling#. Platelet MEKK3 regulates arterial thrombosis and myocardial infarct expansion in mice. Blood Adv. 2018 Jun 26;2(12):1439-1448.

10. Shi P, Zhang L, Zhang M, Yang W, Wang K, Zhang J, Otsu K, Huang G, Fan X, Liu J#. Platelet-Specific p38α Deficiency Improved Cardiac Function After Myocardial Infarction in Mice. Arterioscler Thromb Vasc Biol. 2017 Dec;37(12):e185-e196.

11. Gao W, Shi P, Chen X, Zhang L, Liu J#, Fan X, Luo X. Clathrin-mediated integrin αIIbβ3 trafficking controls platelet spreading. Platelets. 2017 Sep 29:1-12.

12. Wang Y, Jiang L, Mo X, Lan Y, Yang X, Liu X, Zhang J, Zhu L, Liu J#, Wu X. Megakaryocytic Smad4 Regulates Platelet Function through Syk and ROCK2 Expression. Mol Pharmacol. 2017;92(3):285-296.

13. Cheng Z, Gao W, Fan X, Chen X, Mei H, Liu J#, Luo X, Hu Y. Extracellular signal-regulated kinase 5 associates with casein kinase II to regulate GPIb-IX-mediated platelet activation via the PTEN/PI3K/Akt pathway. J Thromb Haemost. 2017;15(8):1679-1688.

14. Zhou J, Wu Y, Chen F, Wang L, Rauova L, Hayes VM, Poncz M, Li H, Liu T, Liu J#,Essex DW. The disulfide isomerase ERp72 supports arterial thrombosis in mice. Blood. 2017;130(6):817-828.

15. Lai W, Cai Y, Zhou J, Chen S, Qin C, Yang C, Liu J, Xie X, Du C. Deficiency of the G protein Gαq ameliorates experimental autoimmune encephalomyelitis with impaired DC-derived IL-6 production and Th17 differentiation. Cell Mol Immunol. 2017;14(6):557-567.

16. Chen Y, Yang W, Guo L, Wu X, Zhang T, Liu J, Zhang J. Atractylodes lactone compounds inhibit platelet activation. Platelets. 2017;28(2):194-202.

17. Zhang J, Li Z, Hu X, Su Q, He C, Liu J, Ren H, Qian M, Liu J, Cui S, Jiang W. Knockout of P2Y12 aggravates experimental autoimmune encephalomyelitis in mice via increasing of IL-23 production and Th17 cell differentiation by dendritic cells. Brain Behav Immun. 2017;62:245-255.

18. Chen X, Fan X, Tan J, Shi P, Wang X, Wang J, Kuang Y, Fei J, Liu J, Dang S, Wang Z. Palladin is involved in platelet activation and arterial thrombosis. Thromb Res. 2017;149:1-8.

19. Zhang W, Ren H, Xu C, Zhu C, Wu H, Liu D, Wang J, Liu L, Li W, Ma Q, Du L, Zheng M, Zhang C, Liu J, Chen Q. Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injury. Elife. 2016 Dec 20;5. pii: e21407.

20. Gu H, Chen C, Hao X, Wang C, Zhang X, Li Z, Shao H, Zeng H, Yu Z, Xie L, Xia F, Zhang F, Liu X, Zhang Y, Jiang H, Zhu J, Wan J, Wang C, Weng W, Xie J, Tao M, Zhang CC, Liu J*, Chen GQ, Zheng J. Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis. J Clin Invest. 2016 Dec 1;126(12):4537-4553. doi: 10.1172/JCI87105. Epub 2016 Oct 31.

21. Dai J, Lu Y, Wang C, Chen X, Fan X, Gu H, Wu X, Wang K, Gartner TK, Zheng J, Chen G, Wang X, Liu J*. Vps33b regulates Vwf-positive vesicular trafficking in megakaryocytes. J Pathol. 2016;240(1):108-19.

22. Cheng Z, Liu J. Receptor-mediated inhibitory mechanisms and the regulation of platelet function. Sci China Life Sci. 2015;58(12):1299-301.

23. Fan X, Chen X, Wang C, Dai J, Lu Y, Wang K, Liu J, Zhang J, Wu X. Drospirenone enhances GPIb-IX-V-mediated platelet activation. J. Thromb. Haemost., 2015;13(10):1918-24.

24. Zhi H, Dai J, Liu J, Zhu J, Newman DK, Gao C, Newman PJ. Platelet Activation and Thrombus Formation over IgG Immune Complexes Requires Integrin αIIbβ3 and Lyn Kinase. PLoS One., 2015;10(8):e0135738.

25. Liang Y, Fu Y, Qi R, Wang M, Yang N, He L, Yu F, Zhang J, Yun CH, Wang X, Liu J, Kong W. Cartilage oligomeric matrix protein is a natural inhibitor of thrombin. Blood. 2015;126(7):905-14.

26. Di C, Lin X, Zhang Y, Zhong W, Yuan Y, Zhou T, Liu J, Xia Z. Basophil-associated OX40 ligand participates in the initiation of Th2 responses during airway inflammation. J. Biol. Chem., 2015;290(20):12523-36.

27. Yao T, Ying X, Zhao Y, Yuan A, He Q, Tong H, Ding S, Liu J, Peng X, Gao E, Pu J, He B. Vitamin D Receptor Activation Protects against Myocardial Reperfusion Injury through Inhibition of Apoptosis and Modulation of Autophagy. Antioxid. Redox. Signal., 2015;22(8):633-50.

28. Delaney MK, Liu J, Kim K, Shen B, Stojanovic-Terpo A, Zheng Y, Cho J, Du X. Agonist-induced platelet procoagulant activity requires shear and a Rac1-dependent signaling mechanism. Blood, 2014;124(12):1957-67.

29. Fan X, Shi P, Dai J, Lu Y, Chen X, Liu X, Zhang K, Wu X, Sun Y, Wang K, Zhu L, Zhang CC, Zhang J, Chen GQ, Zheng J, Liu J*. Paired immunoglobulin-like receptor B regulates platelet activation. Blood, 2014;124(15):2421-30.

30. 30.Xu Z, Chen X, Zhi H, Gao J, Bialkowska K, Byzova TV, Pluskota E, White GC 2nd, Liu J, Plow EF, Ma YQ. Direct interaction of kindlin-3 with integrin αIIbβ3 in platelets is required for supporting arterial thrombosis in mice. Arterioscler. Thromb. Vasc. Biol., 2014;34(9):1961-7.

31. Wang L, Wu Y, Zhou J, Ahmad SS, Mutus B, Garbi N, Hämmerling G, Liu J, Essex DW. Platelet-derived ERp57 mediates platelet incorporation into a growing thrombus by regulation of the αIIbβ3 integrin. Blood, 2013;122(22):3642-50. 10.

32. Chen X, Zhang Y, Wang Y, Li D, Zhang L, Wang K, Luo X, Yang Z, Wu Y, Liu J*. PDK1 regulates platelet activation and arterial thrombosis. Blood, 2013;121(18): 3718-26.

33. Zhang S, Ye J, Zhang Y, Xu X, Liu J, Zhang SH, Kunapuli SP, and Ding Z. P2Y(12) protects platelets from apoptosis via PI3k-dependent Bak/Bax inactivation. J. Thromb. Haemost., 2013;11(1):149-60.

34. Delaney MK, Liu J, Zheng Y, Berndt MC, and Du X. The role of Rac1 in glycoprotein Ib-IX-mediated signal transduction and integrin activation. Arterioscler. Thromb. Vasc. Biol., 2012;32(11):2761-8.

35. Niu H, Chen X, Gruppo RA, Li D, Wang Y, Zhang L, Wang K, Chai W, Sun Y, Ding Z, Gartner TK, and Liu J#. Integrin αIIb-mediated PI3K/Akt activation in platelets. PLoS One., 2012;7(10):e47356. 8.

36. Li D, Wang Y, Zhang L, Luo X, Li J, Chen X, Niu H, Wang K, Sun Y, Wang X, Yan Y, Chai W, Gartner TK, and Liu J*. Roles of purinergic receptor P2Y, G protein-coupled 12 in the development of atherosclerosis in apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol., 2012;32(8):e81-9. 15.

37. Niu H, Xu Z, Li D, Zhang L, Wang K, Taylor DB, Liu J#, and Gartner TK#. Peptide LSARLAF induces integrin β3 dependent outside-in signaling in platelets. Thromb. Res., 2012;130(2):203-9.

38. Weng Z, Li D, Zhang L, Chen J, Ruan C, Chen G, Gartner TK, and Liu J#. PTEN Regulates Collagen Induced Platelet Activation. Blood, 2010;116(14):2579-81.21.

39. Zhang S, Hu L, Du H, Guo Y, Zhang Y, Niu H, Jin J, Zhang J, Liu J, Zhang X, Kunapuli SP, and Ding Z. BF0801, a novel adenine derivative, inhibits platelet activation via PDE inhibition and P2Y12 antagonism. Thromb. Haemost., 2010;104(4):845-57. 9.

40. Xiang B, Zhang G, Liu J, Morris AJ, Smyth SS, Gartner TK, and Li Z. A Gi-independent mechanism mediating Akt phosphorylation in platelets. J. Thromb. Haemost., 2010;8(9):2032-41. 19.

41. Li Z, Zhang G, Liu J, Stojanovic A, Ruan C, Lowell CA, and Du X. An important role of the SRC family kinase LYN in stimulating platelet granule secretion. J. Biol. Chem., 2010;285(17):12559-70. 13.

42. Guerrero JA, Kyei M, Russell S, Liu J, Gartner TK, Storrie B, and Ware J. Visualizing the von Willebrand factor/glycoprotein Ib-IX axis with a platelet-type von Willebrand disease mutation. Blood, 2009;114(27): 5541-6. 11.

43. Flevaris P, Li Z, Zhang G, Zheng Y, Liu J, and Du X. Two distinct roles of mitogen-activated protein kinases in platelets and a novel Rac1-MAPK- dependent integrin outside-in retractile signaling pathway. Blood, 2009;113(4):893-901. 52.

44. Liu J*, Joglekar M, Ware J, Fitzgerald MEC, Lowell CA, Berndt MC, and Gartner TK. Evaluation of the physiological significance of botrocetin/von Willebrand factor in vitro signaling. J. Thromb. Haemost., 2008;6(11):1915-22.

45. Liu J*, Jackson CW, and Gartner TK. The Src requirement for washed platelet aggregation and dense granule secretion in response to stimulation by a low level gamma-thrombin. J. Thromb. Haemost., 2008;6(6):1035-7.

46. Yin H, Liu J, Li Z, Berndt MC, Lowell CA, and Du X. Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway. Blood, 2008;112(4):1139-46. 35.

47. Guerrero JA, Shafirstein G, Russell S, Varughese KI, Kanaji T, Liu J, Gartner TK, Bäumler W, Jarvis GE, and Ware J. In vivo relevance for platelet glycoprotein Ibalpha residue Tyr276 in thrombus formation. J. Thromb. Haemost., 2008;6(4):684-91.

48. Jain S, Zuka M, Liu J, Russell S, Dent J, Forsyth J, Maruszak B, Gartner TK, Habermann BF, and Ware J. Platelet glycoprotein Ib alpha supports experimental lung metastasis. Proc. Natl. Acad. Sci. USA., 2007;104(21):9024-8. 96.

49. Liu J, Ware J, Jackson CW, and Gartner TK. FcRgamma-chain dependent alphallbbeta3 elicited outside-in signaling. J. Thromb. Haemost., 2007;5(2):426-8.

50. 50.Liu J, Ware J, Jackson CW, and Gartner TK. FcRgamma-chain signals in the absence of GPVI. J. Thromb. Haemost., 2007;5(1):201-3.

51. Liu J, Fitzgerald MEC, Berndt MC, Jackson CW, and Gartner TK. Bruton’s tyrosine kinase is essential for botrocetin/ vWf-induced signaling and GPIb-dependent thrombus formation in vivo. Blood, 2006;108(8):2596-603. 45.

52. Zhao M, Liu J, Wang C, Wang L, Liu H, and Peng S. Synthesis and Biological Activity of Nitronyl Nitroxide Containing Peptides. J. Med. Chem., 2005;48(13),4285 -92.

53. Liu J, Pestina TI, Berndt MC, Steward SA, Jackson CW, and Gartner TK. Botrocetin/vWf-induced signaling through GPIb-IX-V produces TxA2 in a Ca2+ and aggregation-independent manner without utilizing other receptors. Blood, 2005;106:2750-2756. 43.

54. Liu J, Jackson CW, Gruppo RA, Jennings LK, and Gartner TK. The β3 Subunit of the Integrin αIIbβ3 Regulates αIIb-mediated Outside-in Signaling. Blood, 2005;105:4345-4352. 23.

55. Liu J, Pestina TI, Berndt MC, Steward SA, Jackson CW, and Gartner TK. The roles of ADP and TXA2 in botrocetin/vWf- induced aggregation of washed platelets. J. Thromb. Haemost., 2004;2:2213-2222.

56. Cho MJ, Liu J, Pestina TI, Steward SA, Thomas DW, Coffman TM, Wang D, Jackson CW, and Gartner TK. The roles of alpha IIb beta 3-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregation. Blood, 2003;101(7):2646-51. 60.

57. Cho MJ, Liu J, Pestina TI, Steward SA, Jackson CW, and Gartner TK.  AlphaIIbbeta3-mediated outside-in signaling induced by the agonist peptide LSARLAF utilizes ADP and thromboxane A2 receptors to cause alpha-granule secretion by platelets. J. Thromb. Haemost., 2003;1(2):363-73.

58. Liu J, Zhao M, Wang C, and Peng S. Synthesis and bioactivities of nitronyl nitroxide and RGD containing pseudopeptides. Bioorg Med Chem Lett., 2003;13(22):4065-4069. 12.

59. Wo L, Zhang X, Ma C, Zhou C, Li J, Hu Z, Gong X, Zhan M, He M#, Zhao Q#. LncRNA HABON promoted liver cancer cells survival under hypoxia by inhibiting mPTP opening. Cell Death Discov. 2022;8(1):171. doi: 10.1038/s41420-022-00917-6.

60. Zhang Y, Long X, Ruan X, Wei Q, Zhang L, Wo L, Huang D, Lin L, Wang D, Xia L, Zhao Q, Liu J, Zhao Q#, He M#. SIRT2-mediated deacetylation and deubiquitination of C/EBPβ prevents ethanol-induced liver injury. Cell Discov. 2021; 7 (9). doi: 10.1038/s41421-021-00326-6.

61. Ma C*, Wo L*, Wang D, Zhou C, Li J, Zhang X, Gong X, Wang C, Chen G, He M#, Zhao Q#. (2021) Hypoxia activated long non-coding RNA HABON regulates the growth and proliferation of hepatocarcinoma cells by binding to and antagonizing HIF-1 alpha. RNA Biol. doi: 10.1080/15476286.2020.1871215.

62. Wei Q, Zhang Y, Lin L, He E, He Y, Su Y, Duan C, Wang S, Zhao Q, Zhao Q, He M#. Haptoglobin suppresses hepatocyte ferroptosis via inhibition of the ERK1/2 signaling pathway. Journal of Shanghai Jiaotong University (Medical Science). 2021 (8):  999-1008.  doi: 10.3969/j.issn.1674-8115.2021.08.002.

63. He M#, Zhang Y, Wei Q, Ruan X, An X, Sun Y. LPS induces acute liver injury by down-regulating SIRT2 in hepatocyte. Current Immunology. 2021; 41(1):8-13;55.

64. Wang CL, Li JC, Zhou CX, Ma CN, Wang DF, Wo LL, He M, Yin Q, He JR, Zhao Q. Long non-coding RNA ARHGAP5-AS1 inhibits migration of breast cancer cell via stabilizing SMAD7 protein. Breast Cancer Res Treat. 2021;189(3):607-619. doi: 10.1007/s10549-021-06286-5.

65. He M#, Wei Q, Zhang Y. Research progress on the mechanism of ferroptosis and its role in liver related diseases. Journal of Shanghai Jiaotong University (Medical Science). 2020, 40(12): 1519-1523.

66. He M*, Chiang H*, Luo H*, Zheng Z*, Qiao Q, Wang L, Tan M, Ohkubo R, Mu W, Zhao S, Wu H, Chen D. (2020) An acetylation switch of the NLRP3 inflammasome regulates aging-associated chronic inflammation and insulin resistance. Cell Metab. 31(3): 580-591.e5. doi: 10.1016/j.cmet.2020.01.009.

67. Ruan X, Zhang Y, Han K, Lin L, Chen C, Yue M, Wang C, Sun Y, Zhao Q, He M#. (2019) SIRT7 protects hepatocytes from LPS or D-GalN/LPS-induced apoptosis by attenuating endoplasmic reticulum stress via inactivation of GRP78. Journal of Shanghai Jiaotong University (Medical Science). 39(8):928-935.

68. Peng Y, Han K, Ruan X, Zhang Y, Wei Q, Zhao Y, An X, He M#. (2019) Expression of p53, TGFβ1 and inflammatory cytokines in a novel alcoholic renal injury mouse model.Current Immunology. 39(5):26-31.

69. Zhang Y, Wu Y, He M#. (2019) Application of CD229 in immunophenotyping of plasma cell diseases. Laboratory Medicine.34(7):605-609.

70. Lin S, Xing H, Zang T, Ruan X, Wo L, He M#. (2018)  Sirtuins in mitochondrial stress: indispensable helpers behind the scenes. Ageing Res Rev. 44:22-32. doi: 10.1016/j.arr.2018.03.006.

71. Wang QY, Zhou CX, Zhan MN, Tang J, Wang CL, Ma CN, He M, Chen GQ, He JR, Zhao Q. (2018). MiR-133b targets Sox9 to control pathogenesis and metastasis of breast cancer. Cell Death Dis. 9(7):752. doi: 10.1038/s41419-018-0715-6.

72. Gong X, Yu A, Tang J, Wang C, He J, Chen G, Zhao Q, He M#, Zhou C#. (2018) MicroRNA-630 inhibits breast cancer progression by directly targeting BMI1. Exp Cell Res. 362(2):378-385. doi: 10.1016/j.yexcr.2017.11.039.

73. Han K, Ruan X, He M#. (2018) The roles of SIRT2 in the tumorigenesis and development of hepatocellular carcinoma. Journal of Shanghai Jiaotong University (Medical Science). 10:1247-1251.

74. Wang QY, Zhou CX, Zhan MN, Tang J, Wang CL, Ma CN, He M, Chen GQ, He JR, Zhao Q. (2018) MiR-133b targets Sox9 to control pathogenesis and metastasis of breast cancer. Cell Death Dis. 9(7):752. doi: 10.1038/s41419-018-0715-6.

75. Zang T, Liu H, Wo L, Lin S, Xing H, He M#. (2017) Roles of SIRT2 in glucose lipid metabolism. Sheng Li Ke Xue Jin Zhan. 48(6): 458-462.

76. Zhang L, An X, Ruan X, Huang D, Zhou L, Xue H, Lu L#, He M#. (2017) Inhibition of (pro)renin receptor contributes to renoprotective effects of angiotensin II type 1 receptor blockade in diabetic nephropathy. Front. Physiol. 8:758. doi: 10.3389/fphys.2017.00758. eCollection 2017.

77. An X, Zhang L, Yuan Y, Wang B, Yao Q, Li L, Zhang J#, He M#, Zhang J#. (2017) Hyperoside pre-treatment prevents glomerular basement membrane damage in diabetic nephropathy by inhibiting podocyte heparanase expression. Sci Rep. 7(1):6413. doi: 10.1038/s41598-017-06844-2.

78. An X, Zhang L, Yao Q, Li L, Wang B, Zhang J#, He M#, Zhang J#. (2017) The receptor for advanced glycation endproducts mediates podocyte heparanase expression through NF-κB signaling pathway. Mol Cell Endocrinol. 470:14-25. doi: 10.1016/j.mce.2017.05.004.

79. Huang D, Wo L, Ruan X, Xu Y, Gong Y, Yang L, Li X, Kang Y, He M#. (2017) Construction of a new alcoholic liver disease mouse model. Journal of Shanghai Jiaotong University (Medical Science). 37(7):906-913.

80. Tang J, Zhan MN, Yin QQ, Zhou CX, Wang CL, Wo LL, He M, Chen GQ, Zhao Q. (2017). Impaired p65 degradation by decreased chaperone-mediated autophagy activity facilitates epithelial-to-mesenchymal transition. Oncogenesis. 6(10):e387. doi: 10.1038/oncsis.2017.85.

81. Zhan MN, Yu XT, Tang J, Zhou CX, Wang CL, Yin QQ, Gong XF, He M, He JR, Chen GQ, Zhao Q. (2017) MicroRNA-494 inhibits breast cancer progression by directly targeting PAK1. Cell Death Dis. 8(1):e2529. doi: 10.1038/cddis.2016.440.

82. Zhang L, An XF, Wang QY, He M#. (2016) Activation of cold-sensitive channels TRPM8 and TRPA1 inhibits the proliferative airway smooth muscle cell phenotype. Lung. 194(4):595-603. doi: 10.1007/s00408-016-9901-4.

83. Zhou CX, Wang CL, Yu AL, Wang QY, Zhan MN, Tang J, Gong XF, Yin QQ, He M, He JR, Chen GQ, Zhao Q. (2016) MiR-630 suppresses breast cancer progression by targeting metadherin. Oncotarget. 7(2):1288-99. doi: 10.18632/oncotarget.6339.

84. Zhang L, He M#. (2015) Roles of Sirtuins in occurrence and development of chronic kidney disease. Journal of Shanghai Jiaotong University (Medical Science). 35(4):594-600.

85. He M*, Wang QY*, Yin QQ, Tang J, Lu Y, Zhou CX, Duan CW, Hong DL, Tanaka T, Chen GQ, Zhao Q. (2013) HIF-1 down-regulates miR-17/20a directly targeting p21 and STAT3: a role in myeloid leukemic cell differentiation. Cell Death Differ. 20(3):408-418. doi: 10.1038/cdd.2012.130.

86. Shin J*, He M*, Liu Y*, Paredes S*, Villanova L, Brown K, Qiu X, Nabavi N, Mohrin M, Wojnoonski K, Li P, Cheng HL, Murphy AJ, Valenzuela DM, Luo H, Kapahi P, Krauss R, Mostoslavsky R, Yancopoulos GD, Alt FW, Chua KF, Chen D. (2013) SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. Cell Rep. 5(3): 654-665. doi: 10.1016/j.celrep.2013.10.007.

87. Liang YJ, Wang QY, Zhou CX, Yin QQ, He M, Yu XT, Cao DX, Chen GQ, He JR, Zhao Q. (2013). MiR-124 targets slug to regulate epithelial-to-mesenchymal transition and metastasis of breast cancer. Carcinogenesis. 34(3):713-722. doi: 10.1093/carcin/bgs383.

88. Liu XX, Li XJ, Zhang B, Liang YJ, Zhou CX, Cao DX, He M, Chen GQ, He JR, Zhao Q. (2011). MicroRNA-26b is underexpressed in human breast cancer and induces cell apoptosis by targeting SLC7A11. FEBS Lett. 585(9):1363-1367. doi: 10.1016/j.febslet.2011.04.018.

89. Zhang B, Liu XX, He JR, Zhou CX, Guo M, He M, Li MF, Chen GQ, Zhao Q. (2011) Pathologically decreased miR-26a antagonizes apoptosis and facilitates carcinogenesis by targeting MTDH and EZH2 in breast cancer. Carcinogenesis. 32(1):2-9. doi: 10.1093/carcin/bgq209.

90. Ten SC, Gu SY, Niu YF, An XF, Yan M, He M. (2010) Central administration of kisspeptin-10 inhibits water and sodium excretion of anesthetized male rats and the involvement of arginine vasopressin. Endocr Res. 35(3):128-136.

91. Han X, Yan M, An XF, He M, Yu JY. (2010) Central administration of kisspeptin-10 inhibits natriuresis and diuresis induced by blood volume expansion in anesthetized male rats. Acta Pharmacol Sin. 31(2):145-149.

92. He M, Zhang L, Shao Y, Zhou L, Wang XF, Yao T, Lu LM. (2010) Angiotensin II type 2 receptor mediated angiotensin II and high glucose induced decrease in renal renin/prorenin receptor expression. Mol Cell Endocrinol. 315(1-2):188-194. doi: 10.1016/j.mce.2009.10.008.

93. He M, Zhang L, Shao Y, Wang X, Huang Y, Yao T, Lu L. (2009) Inhibition of renin/prorenin receptor attenuated mesangial cell proliferation and reduced associated fibrotic factor release. Eur J Pharmacol. 606(1-3):155-161. doi: 10.1016/j.ejphar.2008.12.050.

94. Chen L, He M, Wang WQ. (2009) High-frequency rotation sensation function damage of the crista of the horizontal semicircular canal induced by gentamicin and its morphological basis. Acta Physiologica Sinica. 61(6):559-566.

95. An XF, He M, Feng Y, Feng H, Yu JY. (2009) Central administration of Orphanin FQ inhibits GnRH secretion by ORL1 receptor in the median eminence of freely moving ovariectomized rats. Neurosci Bull. 25(1):1-6.

96. Shao Y, He M, Zhou L, Yao T, Lu LM. (2008) Chronic Angiotensin (1-7) injection accelerated STZ-induced diabetic renal injure. Acta Pharmacol Sin. 29(7):829-837.

97. An XF, Niu YF, Ten SC, Liu JS, Feng H, He M, Shen XJ. (2008) Orphanin FQ and glutamate connection in the regulation of gonadotropin-releasing hormone secretion in the preoptic area of conscious male rats. Neurosci Lett. 440(2):109-112. doi: 10.1016/j.neulet.2008.05.059.

98. He M, Huang YL, Zhang L, Yao T, Lu LM. (2008). Expression of renin/prorenin receptor in rat kidney and cultured mesangial cells. Acta Physiologica Sinica. 59 (6): 796-804.

99. He M, Lu LM, Yao T. (2004). Effects of renin-angiotensin system on the regulation of renal function and chronic renal insufficiency. Sheng Li Ke Xue Jin Zhan. 35(2):188-192.