Personal Introduction

Lei Shen obtained her Bachelor of Clinical Medicine degree and Ph.D. in Immunology from Nanjing Medical University. She had her postdoctoral training at Baylor College of Medicine and worked as a senior scientist at Stanford University. Currently she is a Principal Investigator at Shanghai Institute of Immunology and Shanghai Jiao Tong University School of Medicine. Her group is interested in understanding the mechanisms by which innate lymphoid cells (ILCs) adapt to tissue environment to maintain tissue homeostasis and ILCs contribute to inflammatory disease and cancer, with the goal of developing novel therapeutic approaches by targeting ILCs.

Scientific Research Projects

• 2023-2026: Shanghai Natural Science Foundation Project, Principal Investigator, The Role of Neuropilin 1 in Regulating Nerve-ILC2 Communication in Allergic Asthma, project number: 23ZR1455100

• 2023-2024: National Natural Science Fund of China Research Fund for International Scientists, Principal Investigator, Defining the role of mTORC1 in lung ILC2s and asthma, project number: 32250710147

• 2020-2025: The National Key R&D Program of the Ministry of Science and Technology "Protein Machine and Life Process Regulation" key project, participating in the study of protein machine in the interaction between infection of important intestinal pathogens and key host factors to promote the occurrence and development of colorectal cancer, project number: 2020YFA0509, 200November 2020 to October 2025

• 2020-2023: General Program of National Natural Science Foundation of China, Principal Investigator, Liver kinase B1 (LKB1) regulates the function of adipose type 2 innate lymphocytes (ILC2) and affects the occurrence of obesity and type 2 diabetes, project number 81971487

• 2020-2023: Shanghai Natural Science Foundation Project, Principal Investigator, The role and mechanism of SUMO-specific protease 1 (SENP1) in regulating B cell germinal center response and antibody class switching, project number: 20ZR1430200

• 2020-2022: Shanghai "Science and Technology Innovation Action Plan", principal, development and application of FACSymphony high-parameter flow analyzer for panoramic immune monitoring, project number: 20142202300

• 2020-2022: Bidi Medical Devices (Shanghai) Horizontal Project, Principal, Application of scRNAseq and high-parameter flow cytometry to analyze the immune response characteristics of innate lymphocytes in colon cancer tumor microenvironment, project number: 2020HX009

• 2016-2019: General Program of National Natural Science Foundation of China, Principal Investigator, Regulation of SUMO-specific protease 1 on adipose tissue macrophages and its relationship with type 2 diabetes, project number: 81571533

• 2016-2019: General Program of National Natural Science Foundation of China, Principal Investigator, Research on the regulation and mechanism of PLZF on the development and function of type 3 innate lymphocytes (ILC3), project number: 31570921

Publications

1. Lin Hu; Dongdi Wang; Yue Chen; Jinxin Qiu; Hongdong Wang; Youqin Zhang; Michelle Zhang; Xiaohui Su; Ju Qiu; Jiping Sun; Lei Shen; Obesity disrupts ILC2 metabolic and functional homeostasis by inhibiting mTORC1 signaling, Cellular Molecular Immunology, 2026, 23(3): 301-314

2. Dongdi Wang; Lin Hu; Jinyu Chen; Jinxin Qiu; Yue Chen; Michelle Zhang; Linfeng Zhao; Xiaohui Su; Jiping Sun; Ju Qiu; Wei Tang; Wenyong Zhou; Lei Shen; mTORC1 signaling in group 2 innate lymphoid cells coordinates neuro-immune crosstalk in allergic lung inflammation, Nature Communications, 2025, 17(1): 62

3. Jiping Sun; Youqin Zhang; Qingbing Zhang; Lin Hu; Linfeng Zhao; Hongdong Wang; Yue Yuan; Hongshen Niu; Dongdi Wang; Huasheng Zhang; Jianyue Liu; Xujiao Feng; Xiaohui Su; Ju Qiu; Jing Sun; Heping Xu; Catherine Zhang; Kathleen Wang; Yan Bi; Edgar G. Engleman; Lei Shen; Metabolic regulator LKB1 controls adipose tissue ILC2 PD-1 expression and mitochondrial homeostasis to prevent insulin resistance, Immunity, 2024, 57(6): 1289-1305

4. Hongshen Niu; Huasheng Zhang; Dongdi Wang; Linfeng Zhao; Youqin Zhang; Wenyong Zhou; Jingjing Zhang; Xiaohui Su; Jiping Sun; Bing Su; Ju Qiu; Lei Shen; LKB1 prevents ILC2 exhaustion to enhance antitumor immunity, Cell Reports, 2024, 43(5): 113579

5. Jingjing Qi; Lichong Yan; Jiping Sun; Chuanxin Huang; Bing Su; Jinke Cheng; Lei Shen; SUMO- specific protease 1 regulates germinal center B cell response through deSUMOylation of PAX5, Proceedings of the National Academy of Sciences of the United States of America, 2024,121(22)

6. Hongdong Wang; Yanhua Du; Shanshan Huang; Xitai Sun; Youqiong Ye; Haixiang Sun; Xuehui Chu; Xiaodong Shan; Yue Yuan; Lei Shen; Yan Bi; Single-cell analysis reveals a subpopulation of adipose progenitor cells that impairs glucose homeostasis, Nature Communications, 2024, 15(1)

7. Wan-Bing Dai; Xiao Zhang; Xu-Liang Jiang; Yi-Zhe Zhang; Ling-Ke Chen; Wei-Tian Tian;

8. Xiao Xin Zhou; Xiao Yu Sun; Li Li Huang; Xi Yao Gu; Xue Mei Chen; Xiao Dan Wu; Jie Tian; Wei Feng Yu; Lei Shen; Dian San Su; The Kynurenine Pathway Regulated by Intestinal Innate Lymphoid Cells Mediates Postoperative Cognitive Dysfunction, Mucosal Immunology, 2024, 18(1): 53-65

9. Yaru Xu; Huasheng Zhang; Shuai Wu; Jianyue Liu; Hongzhi Liu; Dongdi Wang; Youqin Zhang; Hongshen Niu; Xiaohui Su; Jiping Sun; Lei Shen; PLZF restricts intestinal ILC3 function in gut defense, Cellular Molecular Immunology, 2023, 20(4): 379-388

10. Jingjing Zhang; Jinxin Qiu; Wenyong Zhou; Jianping Cao; Xuefei Hu; Wenli Mi; Bing Su; Bin He; Ju Qiu; Lei Shen; Neuropilin-1 mediates lung tissue-specific control of ILC2s function in type 2 immunity, Nature Immunology, 2022, 23(2): 237-250

11. Jiaqing Zhou; Jingjing Zhang; Lu Tao; Kexin Peng; Qiaoan Zhang; Kexiang Yan; Jing Luan; Jiewen Pan; Xiaohui Su; Jiping Sun; Zhenghua Zhang; Lei Shen; Up-regulation of BTN3A1 on CD14+cells promotes Vγ9Vδ2 T cell activation in psoriasis, Proceedings of the National Academy of Sciences of the United States of America, 2022, 119(44)

12. Lei Shen; Youqiong Ye; Hongxiang Sun; Bing Su; ILC3 plasticity in microbiome-mediated tumor progression and immunotherapy, Cancer cell, 2021, 39(10): 1308-1310

13. Jinxin Qiu, Jingjing Zhang, Yan Ji, Hanxiao Sun, Zhitao Gu, Qiangling Sun, Meizhu Bai, Jue Gong, Jupei Tang, Yunpeng Zhang, Shiyang Li, Zhen Shao, Jinsong Li, Huiming Sheng, Lei Shen, Ju Qiu; Tissue signals imprint Aiolos expression in ILC2s to modulate type 2 immunity, Mucosal Immunology, 2021, 14(6): 1306-1322

14. Liang Gao, Qian Yu, Huasheng Zhang, Zhengting Wang, Tianyu Zhang, Jinnan Xiang, Shuxiang Yu, Shaoyang Zhang, Hongguang Wu, Yizhou Xu, Zhuo Wang, Lu Shen, Gang Shu, Ye-Guang Chen, Huijuan Liu, Lei Shen, Baojie Li; A resident stromal cell population actively restrains innate immune response in the propagation phase of colitis pathogenesis in mice, Science Translational Medicine, 2021 Jul 21;13(603):eabb5071

15. Jingjing Qi; Adeline Crinier; Bertrand Escalie` re; Youqiong Ye; Zhengting Wang; Tianyu Zhang; Luciana Batista; Hongzhi Liu; Liwen Hong; Ningbo Wu; Mingnan Zhang; Lei Chen; Yingbin Liu; Lei Shen; Emilie Narni-Mancinelli; Eric Vivier; Bing Su; Single-cell transcriptomic landscape reveals tumor specific innate lymphoid cells associated with colorectal cancer progression, Cell Reports Medicine, 2021, 2(8) :100353

Patent

• Modulation of cytokine signaling regulators and applications for Immunotherapy”, Licensing to ImmunoVac in April 2007. US Application Number:WO 2005US22396, US Publication Number: US7868158 B2.