Shanghai Institute of Immunology & Department of Immunology and Microbiology
Shanghai Institute of Immunology & Department of Immunology and Microbiology

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WANG Feng

Email: wangfeng16@sjtu.edu.cn

Tel: 021-53594658

Research Field: Molecular mechanism of T cell antigen recognition and immunotherapy

Laboratory of T cell Antigen Recognition and Immunotherapy

Personal Introduction

Dr. Feng Wang is a Professor and Principal Investigator at Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine. He was awarded with the National High Level Talents Special Support Plan, the Program for Professor of Special Appointment (Eastern Scholar), Shanghai Pujiang Program, Shanghai Shuguang Scholar and the Top Young Talent Program of Shanghai. His research was supported by National Natural Science Foundation of China (Key Program and General Program) and the National Key Research and Development Program of China. Dr. Feng Wang has been dedicated to research on T cell antigen recognition and signaling mechanisms, as well as the role of antigen-specific T cells in immunotherapy for major diseases such as cancer. He has published a series of research papers as corresponding author in international journals including Immunity, Science Immunology, JEM, PNAS, Cell Chemical Biology and EMBO Journal. As the first inventor, he has applied for 13 national and international patents and has initiated clinical trials for TCR-T immunotherapy in solid tumors. Dr. Feng Wang is Review Editor at eLife and serves as reviewer for a number of journals including, Cancer Cell, Immunity, Nature Communications, JEM and JCI.

Education:

  • Ph.D. Biochemistry and Molecular Biology, 2010

  • National Institute of Biological Sciences (NIBS) and Beijing Normal University, Beijing, China

  • B.S. Biology, 2005

  • Beijing Normal University, Beijing, China

Research experience:

  • Professor and Principal Investigator, 2016-present

  • Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine

  • Postdoctoral Research Associate, 2010-2016

  • Stanford University School of Medicine, Howard Hughes Medical Institute, Stanford, CA, USA

  • Advisor: Prof. Mark M. Davis

  • Study on the regulation of T cell receptor signaling by lipid metabolites and immune checkpoint blockade-induced anti-tumor immunity and immunopathology

  • Graduate Student, 2005-2010

  • National Institute of Biological Sciences, Beijing, China

  • Advisor: Prof. Xing Wang Deng

  • Study on the mechanism of ubiquitin-mediated proteolysis in signaling transduction

Scientific Research Projects:

  1. NSFC Special Program, 82541045, 2026/01-2028/12, 2840000 RMB, PI.

  2. NSFC Key Program, 82230055, 2023/01-2027/12, 2610000 RMB, PI.

  3. The National Key Research and Development Program of China, 2022YFA0912401, 2022/11-2027/10, 3960000 RMB, PI.

  4. NSFC General Program, 82071852, 2021/01-2024/12, 550000 RMB, PI.

  5. International Collaborative Project of Shanghai Science and Technology Commission, 20410713800, 2020/10-2023/09, 450000 RMB, PI.

  6. The National Key Research and Development Program of China, SQ2018YFA090045-1, 2019/01-2024/12, 1110000 RMB, PI.

  7. Basic Research Project of Shanghai Science and Technology Commission, 18JC1414100, 2018/07-2021/06, 400000 RMB, PI.

  8. Shanghai Jiao Tong University School of Medicine Clinical Collaborative Project, 2019/06-2022/05, 2000000 RMB, PI.

  9. NSFC General Program, 81771739, 2018/01-2021/12, 560000 RMB, PI.

  10. Eastern Scholar Program, 2017/09-2020/08, 1000000 RMB, PI.

  11. Shanghai Pujiang Scholar Program, 17PJ1408400, 2017/07-2019/06, 200000 RMB, PI.

  12. Shanghai Jiao Tong University New Faculty Project, KJ3-0214-16-0133, 2016/11-2019/10, 200000 RMB, PI.

  13. Shanghai Jiao Tong University School of Medicine Startup Package, BJ1-7000-17-4110, 2016/11-2022/10, 3000000 RMB, PI.

Publications:

  1. Pang J, Wang Z, Yang C, Huang L, Qiu Y, Wang H, Huang K, Li X, Yang Z, Pan H, Liu L, Tong X, Li B, Zhang M, Zhong L#, Li Z#, Wang F#. Law-NQO1 redox boosts the pentose phosphate pathway to confer stem-like properties and antitumor durability in effector CD8+ T cells. Cell Chemical Biology, 2026. doi: 10.1016/j.chembiol.2026.02.001.

  2. Huang K, Li X, Liang W, Wu S, Ye Y, Lu Y, Zheng J, Wang W, Zheng Q, Fu G, Gao S, Wang F#. PTMA safeguards mitochondrial integrity to sustain metabolic function and antitumor activity of CD8 T Cells. Science Immunology, 2026 Jan 23;11(115):eadz7275. doi: 10.1126/sciimmunol.adz7275.

  3. Li X, Liang W, Wang W, Sherman E, Huang K, Wang F#. The TCR-SUB1-DOCK2 signaling axis governs autoimmunity by regulating CD4+ T cell migratory capacity. Immunity, 2025 Dec 9:S1074-7613(25)00511-4. doi: 10.1016/j.immuni.2025.11.009.

  4. Liang W, Liang Y, Yu M, Ji C, Wang F#. TCR signaling-enhancing mutation alters lipid metabolism of thymocytes and impairs anti-tumor immunity of mature T cells. PNAS, 2025 Oct 21;122(42):e2507154122. doi: 10.1073/pnas.2507154122.

  5. Qu Y, Liang W, Yu M, Wang C, Luo M, Zhong L, Li Z, Wang F#. MYO1F in neutrophils is required for the response to immune checkpoint blockade therapy. Journal of Experimental Medicine. 2025 Jun 2;222(6):e20241957. doi: 10.1084/jem.20241957.

  6. Wang Y, Li R, Tong R, Chen T, Sun M, Luo L, Li Z, Chen Y, Zhao Y, Zhang C, Wei L, Lin W, Chen H, Qian K, Chen AF, Liu J, Chen L, Li B, Wang F, Wang L, Su B, Pu J#. Integrating single-cell RNA and T cell/B cell receptor sequencing with mass cytometry reveals dynamic trajectories of human peripheral immune cells from birth to old age. Nature Immunology. 2025 Feb;26(2):308-322. doi: 10.1038/s41590-024-02059-6. Epub 2025 Jan 29. PMID: 39881000; PMCID: PMC11785523.

  7. Yang C, Ma Y, Lu Q, Qu Y, Li Y, Cheng S, Xiao C, Chen J, Wang C, Wang F, Xiang AP, Huang W, Tang X, Zheng H. 2-Bromo-1,4-Naphthalenedione promotes CD8+ T cell expansion and limits Th1/Th17 to mitigate experimental autoimmune encephalomyelitis. Journal of Neuroinflammation. 2024 Jul 27;21(1):181. doi: 10.1186/s12974-024-03172-x. PMID: 39068463; PMCID: PMC11283727.

  8. Zhang M, Xu W, Luo L, Guan F, Wang X, Zhu P, Zhang J, Zhou X#, Wang F#, Ye S#. Identification and affinity enhancement of T-cell receptor targeting a KRASG12V cancer neoantigen. Communications Biology, 2024 Apr 29;7(1):512. doi: 10.1038/s42003-024-06209-2.

  9. Deng S, Zhang Y, Wang H, Liang W, Xie L, Li N, Fang Y, Wang Y, Liu J, Chi H, Sun Y, Ye R, Shan L, Shi J, Zan Shen Z, Wang Y, Wang S, Brosseau J, Wang F, Liu G, Quan Y, Xu J. ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion. Cell, 2024 Apr 5:S0092-8674(24)00310-6. doi: 10.1016/j.cell.2024.03.019.

  10. Liu Z, Zhang Y, Ma N, Yang Y, Ma Y, Wang F, Wang Y, Wei J, Chen H, Tartarone A, Velotta JB, Dayyani F, Gabriel E, Wakefield CJ, Kidane B, Carbonelli C, Long L, Liu Z, Su J, Li Z. Progenitor-like exhausted SPRY1+CD8+ T cells potentiate responsiveness to neoadjuvant PD-1 blockade in esophageal squamous cell carcinoma. Cancer Cell, 2023 Oct 7:S1535-6108(23)00327-6. doi: 10.1016/j.ccell.2023.09.011.

  11. Wang Y, Liu Y, Wang Y, Wu Y, Chen Z, Wang F#, Wan X#, Wang F#, Sun X. Macrophage Sult2b1 promotes pathological neovascularization in age-related macular degeneration. Life Science Alliance, 2023; 7;6(11):e202302020. doi: 10.26508/lsa.202302020.

  12. Tong R, Luo L, Zhao Y, Sun M, Li R, Zhong J, Chen Y, Hu L, Li Z, Shi J, Lyu Y, Hu L, Guo X, Liu Q, Shuang T, Zhang C, Yuan A, Sun L, Zhang Z, Qian K, Chen L, Lin W, Chen A, Wang F#, Pu J#. Characterizing the cellular and molecular variabilities of peripheral immune cells in healthy recipients of BBIBP-CorV inactivated SARS-CoV-2 vaccine by single-cell RNA sequencing. Emerging Microbes & Infections, 2023; 12(1):e2187245. doi: 10.1080/22221751.2023.2187245.

  13. Miao N, Wang Z, Wang Q, Xie H, Yang N, Wang Y, Wang J, Kang H, Bai W, Wang Y, He R, Yan K, Wang Y, Hu Q, Liu Z, Li F, Wang F, Ginhoux F, Zhang X, Yin J, Lu L, Wang J. Oxidized mitochondrial DNA induces gasdermin D oligomerization in systemic lupus erythematosus. Nature Communications, 2023; 14(1):872. doi: 10.1038/s41467-023-36522-z.

  14. Zhao X, Xu M, Zhao Z, Wang Y, Liu Y, Zhang T, Wan X, Jiang M, Luo X, Shen Y, Chen L, Zhou M, Wang F#, Sun X#. Bifidobacterium promotes retinal ganglion cell survival by regulating the balance of retinal glial cells. CNS Neuroscience and Therapeutics, 2023; 29(Suppl. 1):146–160. doi: 10.1111/cns.14165.

  15. Liang W, Yi R, Wang W, Shi Y, Zhang J, Xu X, Wang Q, Liu M, Wang F#. Enhancing the antitumor immunity of T cells by engineering the lipid-regulatory site of the TCR/CD3 complex. Cancer Immunology Research, 2022; CIR-21-1118. doi: 10.1158/2326-6066.

  16. Wang Q, Zhu T, Miao N, Qu Y, Wang Z, Chao Y, Wang J, Wu W, Xu X, Xu C, Xia L, Wang F#. Disulfiram bolsters T cell anti-tumor immunity through direct activation of LCK-mediated TCR signaling. EMBO Journal, 2022; e110636. doi: 10.15252/embj.2022110636.

  17. Zhao X, Liang W, Wang Y, Yi R, Luo L, Wang W, Sun N, Yu M, Xu W, Sheng Q, Lu L, Pang J, Lv Z#, Wang F#. Ontogeny of RORγt+ cells in the intestine of newborns and its role in the development of experimental necrotizing enterocolitis. Cell & Bioscience, 2022, 12(1):3.

  18. Wang Y, Jin H, Wang Y, Yao Y, Yang C, Meng J, Tan X, Nie Y, Xue L, Xu B, Zhao H, Wang F#. Sult2b1 deficiency exacerbates ischemic stroke by promoting pro-inflammatory macrophage polarization in mice. Theranostics, 2021, 11(20):10074-10090.

  19. Luo L, Liang W, Pang J, Xu G, Chen Y, Guo X, Wang X, Zhao Y, Lai Y, Liu Y, Li B, Su B, Zhang S, Baniyash M, Shen L, Chen L, Ling Y, Wang Y, Liang Q, Lu H, Zhang Z, Wang F#. Dynamics of TCR repertoire and T cell function in COVID-19 convalescent individuals. Cell Discovery, 2021, 7(1):89.

  20. Qian Y, Yu W, Grzeskowiak C, Li J, Huang H, Guo J, Chen L, Wang F, Zhao F, Boehmer L, Metzner T, Leppert J, Chien Y, Kuo C, Davis MM. Nanoparticle-enabled innate immune stimulation activates endogenous tumor infiltrating T cells with broad antigen specificities. PNAS, 2021, doi.org/10.1073/pnas.2016168118.

  21. Zhao X, Luo X, Sun R, Wang F#, and Sun X#. The interaction between microglia and macroglia in glaucoma, Frontiers in Neuroscience, 2021, doi: 10.3389/fnins.2021.610788.

  22. Wang Y, Zhao X, Gao M, Wan X, Guo Y, Qu Y, Chen Y, Li T, Liu H, Jiang M, Wang F#, and Sun X#. Myosin 1f-mediated Activation of Microglia Contributes to the Photoreceptor Degeneration in a Mouse Model of Retinal Detachment. Cell Death & Disease, 2021, DOI:10.21203/rs.3.rs-80015/v1.

  23. Zhao X, Gao M, Liang J, Chen Y, Wang Y, Wang Y, Xiao Y, Zhao Z, Wan X, Jiang M, Luo X, Wang F#, and Sun X#. SLC7A11 Reduces Laser-Induced Choroidal Neovascularization by Inhibiting RPE Ferroptosis and VEGF Production. Frontiers in Cell and Developmental Biology, 2021, Doi: 10.3389/fcell.2021.639851.

  24. Ren X, Wen W, Fan X, Hou W, Su B, Cai P, Li J, Liu Y, Tang F, Zhang F, Yang Y, He J, Ma W, He J, Wang P, Cao Q, Chen F, Chen Y, Cheng X, Deng G, Deng X, Ding W, Feng Y, Gan R, Guo C, Guo W, He S, Chen J, Liang J, Li Y, Lin J, Ling Y, Liu H, Liu J, Liu N, Liu S, Luo M, Ma Q, Song Q, Sun W, Wang G, Wang F, Wang Y, Wen X, Wu Q, Xu G, Xie X, Xiong X, Xing X, Xu H, Yin C, Yu D, Yu K, Yuan J, Zhang B, Zhang P, Zhang T, Zhao J, Zhao P, Zhou J, Zhou W, Zhong S, Zhong X, Zhang S, Zhu L, Zhu P, Zou B, Zou J, Zou Z, Bai F, Huang X, Zhou P#, Jiang Q#, Huang Z#, Bei J#, Wei L#, Bian X#, Liu X#, Cheng T#, Li X#, Zhao P#, Wang F#, Wang H#, Su B#, Zhang Z#, Qu K#, Wang X#, Chen J#, Jin R#, Zhang Z#. COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas. Cell, 2021, 184(7):1895-1913.

  25. Sun S, Luo L, Liang W, Yin Q, Guo J, Rush MA, Lv Z, Liang Q, Fischbach AM, Sonnenburg LJ, Dodd D, Davis MM#, Wang F#. Bifidobacterium alters the gut microbiota and modulates the functional metabolism of Treg cells in the context of CTLA-4 blockade. PNAS, 2020,117(44): 27509-27515.

  26. Li Y, Wang Y, Yao Y, Griffiths BB, Feng L, Tao T, Wang F, Xu B, Stary CM, Zhao H. Systematic Study of the Immune Components after Ischemic Stroke Using CyTOF Techniques, Journal of Immunology Research, 2020, DOI:https://doi.org/10.1155/2020/9132410.

  27. Zeng J, Dong S, Luo Z, Xie X, Fu B, Li P, Liu C, Yang X, Chen Y, Wang X, Liu Z, Wu J, Yan Y, Wang F, Chen J, Zhang J, Long G, Goldman SA, Li S, Zhao Z, Liang Q. The Zika Virus Capsid Disrupts Corticogenesis by Suppressing Dicer Activity and miRNA Biogenesis. Cell Stem Cell, 2020, DOI:https://doi.org/10.1016/j.stem.2020.07.012.

  28. Zhang S, Liang W, Luo L, Sun S, Wang F#. The role of T cell trafficking in CTLA-4-blockade induced gut immunopathology. BMC Biology, 2020, 18(1):29.

  29. Leng Q#, Tarbe M, Long Q, Wang F#. Preexisting heterologous T cell immunity and neoantigen immunogenicity. Clinical & Translational Immunology, 2020, 9(3):e01111.

  30. Hu Z, Qu G, Yu X, Jiang H, Teng XL, Ding L, Hu Q, Guo X, Zhou Y, Wang F, Li HB, Chen L, Jiang J, Su B#, Liu J#, Zou Q#. Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells. Cell Metabolism, 2019, 30(2):290-302.

  31. Wang Y, Jin H, Wang W, Wang F#, Zhao H#. Myosin1f-mediated neutrophil migration contributes to acute neuroinflammation and brain injury after stroke in mice. Journal of Neuroinflammation, 2019, 16(1):77.

  32. Wang F#, Yin Q, Chen L, and Davis MM#. Bifidobacterium can mitigate intestinal immunopathology in the context of CTLA-4 blockade. PNAS, 2018, 115(1): 157-161.

  33. Wang F, Beck-García K, Zorzin C, Schamel WW, and Davis MM. Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol. Nature Immunology, 2016, 17(7): 844-850.

  34. Zhu P, Wang Y, Oin N, Wang F, Wang J, Deng XW, Zhu D. An Arabidopsis small nucleolar RNA monitors the efficient pre-rRNA processing during ribosome biogenesis. PNAS, 2016, 113(42): 11967-11972.

  35. Roh KH, Lillemeier BF, Wang F, and Davis MM. The coreceptor CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase p56lck. PNAS, 2015, 112(13): 1604-1613.

  36. Wang F, Deng XW. Plant ubiquitin-proteasome pathway and its role in gibberellin signaling. Cell Research, 2011, 21(9): 1286-1294.

  37. Wang F, Zhu D, Huang X, Li S, Gong Y, Yao Q, Fu X, Fan LM, and Deng XW. Biochemical insights on degradation of Arabidopsis DELLA proteins gained from a cell-free assay system. Plant Cell, 2009, 21(8): 2378-2390.

  38. Liu Y, Wang F, Zhang H, He H, Ma L, and Deng XW. Functional characterization of the Arabidopsis ubiquitin-specific protease gene family reveals specific role and redundancy of individual members in development. Plant Journal, 2008, 55(5): 844-856.

  39. Feng S, Martinez C, Gusmaroli G, Wang Y, Zhou J, Wang F, Chen L, Yu L, Iglesias-Pedraz JM, Kircher S, Schafer E, Fu X, Fan LM, and Deng XW. Coordinated regulation of Arabidopsis thaliana development by light and gibberellins. Nature, 2008, 451(7177): 475-479.

BOOK CHAPTER:

  • Sun S, Wang F#. Regulation of Cancer Immune Checkpoints-Molecular and Cellular Mechanisms and Therapy. Chapter 6: Molecular events behind adverse effects. Springer Nature, 2020.

  • Liang W, Wang F#. T-Cell Repertoire Characterization. Chapter 10: Characterization of Mouse CD4 TCR and Its Targeting Antigen. Methods in Molecular Biology, Springer Nature, 2022.

Patent

  • 201910119143.7, Inventor: Wang F（CN 109758484B）

  • 201910533938.2 (PCT/CN2020/096054), Inventor: Wang F（CN 114127091B）

  • 201911164594.9, Inventor: Wang F（CN 112831469B）

  • 201911165137.1, Inventor: Wang F（CN 112830965B）

  • 202010933076.5, Inventors: Wang F, Wang Q（CN 114146073B）

  • 202110421940.8, Inventors: Wang F, Yang C（CN 115212193B）

  • 202111091720.X, Inventors: Wang F, Luo L

  • 202210726141.6, Inventor: Wang F

  • 202210878985.2, Inventor: Wang F, Wang W

  • 202211627464.6, Inventor: Bu J, Wang F, Tong R

  • 202211661411.6, Inventor: Wang F, Xu M

  • 202311751900.5 (P08020241222-PCT/CN2024/140029)，Inventor: Wang F, Li X

  • 202411122109.2, Inventor: Wang F, Liang Y, Liang W

  • 202411417919.0, Inventor: Wang F, Qu Y

  • 202510760337.0, Inventor: Wang F, Huang K, Li X

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