Shanghai Institute of Immunology & Department of Immunology and Microbiology
Shanghai Institute of Immunology & Department of Immunology and Microbiology

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WANG Jing

Email: jingwang@shsmu.edu.cn

Tel: 13816893660

Research Field: Neutrophil, inflammation, imaging

Laboratory of Innate Immune Dynamics

Personal Introduction

Jing Wang received her Ph.D. in Medical Science from Osaka University in 2011 and continued as a postdoctoral fellow in Osaka University (2011~2013) and University of Calgary (2013~2016), where she used intravital imaging to study how neutrophils responde to sterile injury in vivo at the Laboratory of Dr. Paul Kubes. She joined Shanghai Jiao Tong University and Shanghai Institute of Immunology as a Principal Investigator since May, 2018. Her main research interest is to understand how innate immune cells such as neutrophils and macrophages recognize and respond to the presence of "danger agents" and how the specific tissue environment cues may affect such responses.

Publications

  1. Jin Wang#, Wenying Zhao#, Wenjuan Bai#, Dong Dong, Hui Wang, Xin Qi, Ajitha Thanabalasuriar, Youqiong Ye, Tian-le Xu, Hecheng Li, Paul Kubes, Bin Li*, and Jing Wang*. PIEZO1 mediates mechanical reprogramming of neutrophils for proangiogenic specialization in the lung, The Journal of Clinical Investigation, 2025 Jun 2; 135(11):e183796.

  2. Xinqi Fan#; Yingjun Zhou#; Wenjuan Bai#; Xue Li; Liyuan Lin; Huibin Lin; Ming Yang; Xiaofei Yu; Jing Wang; Liang Lin; Wei Wang; Intravital Imaging of Translocated Bacteria via Fluorogenic Labeling of Gut Microbiota in Situ, Proceedings of the National Academy of Sciences, 2025 Feb 19; 122(13): e2415845122.

  3. Wu X, Zhao X, Li F, Wang Y, Ou Y, Zhang H, Li X, Wu X, Wang L, Li M, Zhang Y, Liu J, Xing M, Liu H, Tan Y, Wang Y, Xie Y, Zhang H, Luo Y, Li H, Wang J, Sun L, Li Y, Zhang H*. MLKL-mediated endothelial necroptosis drives vascular damage and mortality in systemic inflammatory response syndrome. Cell Mol Immunol. 2024 Sep;21(11)1309-1321.

  4. Guo W#, Li Z#, Anagnostopoulos G, Kong WT, Zhang S, Chakarov S, Shin A, Qian J, Zhu Y, Bai W, Cexus O, Nie B, Wang J, Hu X, Blériot C, Liu Z, Shen B, Venteclef N, Su B*, Ginhoux F*. Notch signaling regulates macrophage-mediated inflammation in metabolic dysfunction-associated steatotic liver disease. Immunity. 2024 Sep;57(10)2310-2327.e6

  5. Kulle A#, Li Z#, Kwak A, Mancini M, Young D, Avizonis D, Groleau M, Baglole CJ, Behr MA, King IL, Divangahi M, Langais D, Wang J, Blagih J, Penz E, Dufour A, Thanabalasuriar A*. Alveolar macrophage function is impaired following inhalation of berry e-cigarette vapor. Proc Natl Acad Sci U S A., 2024 Oct; 121(40)

  6. Ding T#, Wang Y#, Meng Y, Wu E, Shao Q, Lin S, Yu Y, Qian J, He Q, Zhang J*, Wang J*, Kohane DS*, Zhan C*. Reciprocal interaction with neutrophils facilitates cutaneous accumulation of liposomes. ACS Nano., 2024 Jul 1.

  7. Kang H#, Liu L#, Wang Y, Bai W, Luo Y*, Wang J*. Neutrophil-macrophage communication via extracellular vesicle transfer promotes itaconate accumulation and ameliorates cytokine storm syndrome. Cell Mol Immunol., 2024 Jul;21(7):689-706

  8. Wang Y#, Wang J#, Zhang J#, Wang Y, Wang Y, Kang H, Zhao W, Bai W, Miao N, Wang J. Stiffness sensing via Piezo1 enhances macrophages efferocytosis and promotes resolution of liver fibrosis. Sci. Adv., 2024, Jun 7; 10(23): eadj3289

  9. Du X, Ren B, Li C, Li Q, Kan S, Wang X, Bai W, Wu C, Kassegne K, Yan H, Niu X, Yan M, Xu W, Wassmer S, Wang J*, Cheng G*, Wang Z*. PRL2 regulates neutrophil extracellular trap formation which contributes to severe malaria and acute lung injury. Nat Commun., 2024 Jan 29; 15(1):881

  10. He J, Cao Y, Zhu Q, Wang X, Cheng G, Wang Q, He R, Lu H, Weng Y, Mao G, Bao Y, Wang J, Liu X, Han F, Shi P, Shen XZ. Renal macrophages monitor and remove particles from urine to prevent tubule obstruction. Immunity, 2024 Jan 9;57(1):106-123

  11. Miao N, Wang J*. New insights into the role of the immune inhibitory receptor VSTM1 in autoimmune disease. Cell Mol Immunol., 2024 Jan;21(1): 95-96

  12. Wang J, Dong D, Zhao W, Wang J*. Intravital microscopy visualizes innate immune crosstalk and function in tissue microenvironment. Eur J Immunol., 2023 Oct 13: e2350458

  13. Wang YN, Wang YY, Wang J, Bai WJ, Miao NJ, Wang J*. Vinblastine resets tumor-associated macrophages toward M1 phenotype and promotes antitumor immune response. J Immunother Cancer., 2023 Aug;11(8): e007253

  14. Zhao X, Li L, Sun H, Jiang X, Bai W, Wu N, Wang J, Su B. A novel reporter mouse line for studying alveolar macrophages. Sci China Life Sci., 2023 Jul 6

  15. Huang D, Zhang C, Xiao M, Li X, Chen W, Jiang Y, Yuan Y, Zhang Y, Zou Y, Deng L, Wang Y, Sun Y, Dong W, Zhang Z, Xie L, Yu Z, Chen C, Liu L, Wang J, Yang Y, Yang J, Zhao Y, Zheng J. Redox metabolism maintains the leukemogenic capacity and drug resistance of AML cells. Proc Natl Acad Sci U S A., 2023 Mar 28;120(13)

  16. Yang M, Jiang H, Ding C, Zhang L, Ding N, Li G, Zhang F, Wang J, Deng L, Liu J, Xu Y. STING activation in platelets aggravates septic thrombosis by enhancing platelet activation and granule secretion. Immunity, 2023 Mar 10

  17. Miao N, Wang Z, Wang Q, Xie H, Yang N, Wan Y, Wang J, Kang H, Bai W, Wang Y, He R, Yan K, Wang Y, Hu Q, Liu Z, Li F, Wang F, Ginhoux F, Zhang X, Yin J*, Lu L*, Wang J*. Oxidized mitochondrial DNA induces gasdermin D oligomerization in systemic lupus erythematosus. Nat Commun., 2023 Feb 16;14(1):872

  18. Xu Y, Wang J, Ren H, Dai H, Zhou Y, Ren X, Wang Y, Feng S, Deng X, Wu J, Fu T, Nie T, He H, Wei T, Zhu B, Hui L, Li B, Wang J, Wang H, Chen L, Shi X, Cheng X. Human Endoderm Stem Cells Reverse Inflammation-Related Acute Liver Failure through Cystatin SN-Mediated Inhibition of Interferon Signaling. Cell Research, 2023 Feb; 33(2):147-164

  19. He H, Yang W, Su N, Zhang C, Dai J, Han F, Singhal M, Bai W, Zhu X, Zhu J, Liu Z, Xia W, Liu X, Zhang C, Jiang K, Huang W, Chen D, Wang Z, He X, Kirchhoff F, Li Z, Liu C, Huan J, Wang X, Wei W, Wang J, Augustin HG, Hu J. Activating NO-sGC crosstalk in the mouse vascular niche promotes vascular integrity and mitigates acute lung injury. J Exp Med. 2023 Feb 6;220(2): e20211422

  20. Jia J, Wang M, Meng J, Ma Y, Wang Y, Miao N, Teng J, Zhu D, Shi H, Sun Y, Liu H, Cheng X, Su Y, Ye J, Chi H, Liu T, Zhou Z, Wan L, Chen X, Wang F, Zhang H, Ben J*, Wang J*, Yang C*, Hu Q*. Ferritin triggers neutrophil extracellular trap-mediated cytokine storm through Msr1 contributing to adult-onset Still’s disease pathogenesis. Nat Commun. 2022 Nov 10;13(1):6804 *co-correspondence author

  21. Yu Y, Wang RR, Miao NJ, Tang JJ Zhang YW, Lu XR, Yan PY, Wang J, Jia XM. PD-L1 negatively regulates antifungal immunity by inhibiting neutrophil release from bone marrow. Nat Commun. 2022 Nov 11;13(1):6857

  22. Wang J, Wang J*. Neutrophils, functions beyond host defense. Cell Immunol. 2022 Sep; 379:104579

  23. Wang Q, Zhu T, Miao N, Qu Y, Wang Z, Chao Y, Wang J, Wu W, Xu X, Xu C, Xia L, Wang F. Disulfiram bolsters T-cell anti-tumor immunity through direct activation of LCK-mediated TCR signaling. EMBO J. 2022 May 31: e110636

  24. Wang Y, Wang J*. Intravital Imaging of Inflammatory Response in liver Disease. Front Cell Dev Biol. 2022 Jun 28;10: 922041

  25. An H, Qian C, Huang Y, Li J, Tian X, Feng J, Hu J, Fang Y, Jiao F, Zeng Y, Huang X, Meng X, Liu X, Lin X, Zeng Z, Guilliams M, Beschin A, Chen Y, Wu Y, Wang J, Oggioni MR, Leong J, Veening JW, Deng H, Zhang R, Wang H, Wu J, Cui Y, Zhang JR. Functional Vulnerability of Liver Microphages to Capsules Defines the Outcomes of Bacterial Septic Infections. J Exp Med. 2022 Apr 4;219(4): e20212032

  26. Li G, Wang M, Ding T, Wang J, Chen T, Shao Q, Jiang K, Wang L, Yu Y, Pan F, Wang B, Wei X*, Qian J*, Zhan C. cRGD enables rapid phagocytosis of liposomal vancomycin for intracellular bacterial clearance. Journal of controlled release 2022 April 344, 202-213

  27. Wang C, Zhang L, Sun Z, Yuan X, Wu B, Cen J, Cui L, Zhang K, Li C, Wu J, Shu Y, Sun W, Wang J, Hui L*. Dedifferentiation-associated inflammatory factors of long-term expanded human hepatocytes exacerbate their elimination by macrophages during liver engraftment. Hepatology 2022 Mar 1.

  28. Li D, Xiong W, Wang Y, Feng J, He Y, Du J, Wang J, Yang M, Zeng H, Yang Y, Wu N, Chen S*, Dong Z* SLAMF3 and SLAMF4 are immune checkpoints that constrain macrophage phagocytosis of hematopoietic tumors. Sci Immunol. 2022 Jan 21;7(67)

  29. Zhao D, Yang F, Wang Y, Li S, Li Y, Hou F, Yang W, Liu D, Tao Y, Li Q, Wang J*, He F*, Tang L*. ALK1 signaling is required for the homeostasis of Kupffer cells and prevention of bacterial infection. J Clin Invest. 2021 Dec 7: e150489 *co-correspondence author

  30. Wang H, Ding T, Guan J, Liu X, Wang J, Jin P, Hou S, Lu W, Qian J, Wang W, and Zhan C*. Interrogation of folic acid-functionalized nanomedicines: The regulatory roles of plasma proteins reexamined. ACS Nano 2020, 14, 14779-14789

  31. Yang X, Cheng X, Tang Y, Qiu X, Wang Z, Fu G, Wu J, Kang H, Wang J, Wang H, Chen F, Xiao X, Billiar T, Lu B*. The role of type 1 interferons in Gram-negative bacteria-induced coagulation. Blood 135 (14), 1087-1100, 2020

  32. Bartneck M, Wang J*. Therapeutic Targeting of Neutrophil Granulocytes in Inflammatory Liver Disease. Front. Immunol.,10:2257, 2019

  33. Wang J. Neutrophils in tissue injury and repair. Cell Tissue Res 371(3):531-539, 2018

  34. Wang J*, Hossain M*, Thanabalasuriar A, Gunzer M, Meininger C, Kubes P. Visualizing the Function and Fate of Neutrophils in Sterile Injury and Repair. Science 358(6359): 111-116, 2017 * Contribute equally

  35. Thanabalasuriar A, Neupane AS, Wang J, Krummel MF, Kubes P. iNKT cell emigration out of the lung vasculature requires neutrophils and monocyte-derived dendritic cells in inflammation. Cell Reports 16(12): 3260-72, 2016

  36. Wang J, Kubes P. A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade Visceral Organs to Affect Tissue Repair. Cell 165(3): 668-78, 2016

  37. Slaba I, Wang J, Kolaczkowska E, McDonald B, Lee WY, Kubes P. Imaging the Dynamic Platelet-Neutrophil Response in Sterile Liver Injury and Repair in Mice. Hepatology 62(5): 1590-605, 2015

  38. Watson RL, Buck J, Levin LR, Winger RC, Wang J, Arase H, Muller WA. Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration. The Journal of Experimental Medicine 212(4): 447-56, 2015

  39. Dal-Secco D*, Wang J*, Zeng Z, Kolaczkowska E, Wong C, Petri B, Ransohoff R, Charo I, Jenne C, Kubes P. A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+ monocytes at a site of sterile injury. The Journal of Experimental Medicine 212(4): 447-56, 2015 *Contribute equally

  40. Kishida K, Kohyama M, Kurashima Y, Wang J, Hirayasu K, Suenaga T, Kiyono H, Kunisawa J, Arase H. Negative regulation of DSS-induced experimental colitis by PILR. International Immunology 27(6): 307-14, 2015

  41. Kuroki K*, Wang J*, Ose T*, Yamaguchi M*, Tabata S*, Maita N, Nakamura S, Kajikawa M, Kogure A, Satoh T, Arase H, Maenaka K. Structural basis for simultaneous recognition of an O-glycan and its attached peptide of mucin family by immune receptor PILR. Proceedings of the National Academy of Sciences 111(24): 8877-82, 2014* Contribute equally

  42. Wang J*, Arase H. Regulation of immune response by neutrophils. Annals of the New York Academy of Sciences 1319: 66-81, 2014 *Correspondence author

  43. Wang J, Shiratorri I, Uehori J, Ikawa M, Arase H. Neutrophil infiltration during inflammation is regulated by PILR via modulation of integrin activation. Nature Immunology 14: 34-40, 2013

  44. Kogure A, Shiratori I, Wang J, Lanier LL, Arase H. PANP is a novel O-glycosylated PILRa ligand expressed in neural tissues. Biochemical and Biophysical Research Communications 405: 428-33, 2011

  45. Arii J*, Wang J*, Morimoto T, Suenaga T, Akashi H, Arase H, Kawaguchi Y. A single-amino-acid substitution in herpes simplex virus 1 envelope glycoprotein B at a site required for binding to the paired immunoglobulin-like type 2 receptor a (PILRa) abrogates PILRa-dependent viral entry and reduces pathogenesis. Journal of Virology 84: 10773-10783, 2010 *Contribute equally

  46. Wang J, Fan Q, Satoh T, Arii J, Lanier LL, Spear PG, Kawaguchi Y, Arase H. Binding of herpes simplex virus glycoprotein B (gB) to paired immunoglobulin-like type 2 receptor a depends on specific sialylated O-linked glycans on gB. Journal of Virology 83: 13042-13045, 2009

  47. Satoh T, Arii J, Suenaga T, Wang J, Kogure A, Uehori J, Arase N, Shiratori I, Tanaka S, Kawaguchi Y, Spear PG, Lanier LL, Arase H. PILRa is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B. Cell 132: 935-944, 2008

  48. Tabata S, Kuroki K, Wang J, Kajikawa M, Shiratori I, Kohda D, Arase H, Maenaka K. Biophysical characterization of O-glycosylated CD99 recognition by paired Ig-like type 2 receptors. Journal of Biological Chemistry 283: 8893-8901, 2008

  49. Wang J, Shiratori I, Satoh T, Lanier LL, Arase H. An essential role of sialylated O-linked sugar chains in the recognition of mouse CD99 by paired Ig-like type 2 receptor (PILR). Journal of Immunology 180: 1686-1693, 2008

  50. Tabata S, Kuroki K, Maita N, Wang J, Shiratori I, Arase H, Kohda D, Maenaka K. Expression, crystallization and preliminary X-ray diffraction analysis of human paired Ig-like type 2 receptor alpha (PILRa). Acta Crystallographica Section F: Structural Biology and Crystallization Communications 64: 44-46, 2008

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