Personal Introduction

Prof. Wang obtained her B.Med in Medical Laboratory Science and M.Sc in Microbiology at Shanghai Second Medical University. She received her Ph.D. degree in Immunology from Shanghai Jiao Tong University in 2006. In 2008, Dr. Wang became a Postdoctoral Researcher in the Department of Pathology and Laboratory Science, University of Pennsylvania School of Medicine and returned to Shanghai Jiao Tong University School of Medicine in 2012.

Prof. Wang is an expert in the research of infectious diseases. Her lab focuses on how leukocytes adapt to infectious or inflammatory environments and regulate their functions in response to diverse pathogens. She has published more than 50 original research articles in peer-reviewed journals such as Nature Immunology, Nature communications, Cell death and differentiation.

Prof. Wang is a Zhiyuan Honors Teaching Faculty in Shanghai Jiao Tong University. As a Principle Teacher and Course Leader, she is response for Foundation of Diseases, Medical Microbiology and Parasitology courses, Global Health and One Health for undergraduate and graduate students.

Publications

1. Guo, X. et al. PRL2 negatively regulates FcepsilonRI mediated activation of mast cells. Cell Death Dis 16, 322, doi:10.1038/s41419-025-07649-2 (2025).

2. Lei, Y. et al. Synovial microenvironment-influenced mast cells promote the progression of rheumatoid arthritis. Nature communications 15, 113, doi:10.1038/s41467-023-44304-w (2024).

3. Huang, Y.-L., Zhang, K.-Y., Sun, Y.-L., Qian, M.-B. & Wang, Z. The risk of hepatobiliary complications in Clonorchis and Opisthorchis infection: A systematic review and meta-analysis. Acta tropica 260, 107457, doi:10.1016/j.actatropica.2024.107457 (2024).

4. Du, X. et al. PRL2 regulates neutrophil extracellular trap formation which contributes to severe malaria and acute lung injury. Nature communications 15, 881, doi:10.1038/s41467-024-45210-5 (2024).

5. Li, Q. et al. HSC70 mediated autophagic degradation of oxidized PRL2 is responsible for osteoclastogenesis and inflammatory bone destruction. Cell death and differentiation 30, 647-659, doi:10.1038/s41418-022-01068-y (2023).

6. Li, Q. et al. Clonorchis sinensis calcium-binding protein Cs16 causes acute hepatic injury possibly by reprogramming the metabolic pathway of bone marrow-derived monocytes. Front Cell Infect Microbiol 13, 1280358, doi:10.3389/fcimb.2023.1280358 (2023).

7. Kan, S. et al. Clonorchis sinensis infection modulates key cytokines for essential immune response impacted by sex. PLoS neglected tropical diseases 16, e0010726, doi:10.1371/journal.pntd.0010726 (2022).

8. Wu, C. et al. Schistosoma japonicum SjE16.7 Protein Promotes Tumor Development via the Receptor for Advanced Glycation End Products (RAGE). Frontiers in immunology 11, 1767, doi:10.3389/fimmu.2020.01767 (2020).

9. Du, X. et al. PRL2 serves as a negative regulator in cell adaptation to oxidative stress. Cell & bioscience 9, 96, doi:10.1186/s13578-019-0358-z (2019).

10. Yin, C. et al. PRL2 Controls Phagocyte Bactericidal Activity by Sensing and Regulating ROS. Frontiers in immunology 9, 2609, doi:10.3389/fimmu.2018.02609 (2018).

11. Fayngerts, S. A. et al. Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2. Nature immunology 18, 1353-1360, doi:10.1038/ni.3866 (2017).

12. Fang, Y. et al. SjE16.7 activates macrophages and promotes Schistosoma japonicum egg-induced granuloma development. Acta tropica 149, 49-58, doi:10.1016/j.actatropica.2015.05.016 (2015).

13. Wu, C. et al. Schistosoma japonicum egg specific protein SjE16.7 recruits neutrophils and induces inflammatory hepatic granuloma initiation. PLoS neglected tropical diseases 8, e2703, doi:10.1371/journal.pntd.0002703 (2014).

14. Wang, Z. et al. TIPE2 protein serves as a negative regulator of phagocytosis and oxidative burst during infection. Proceedings of the National Academy of Sciences of the United States of America 109, 15413-15418, doi:10.1073/pnas.1204525109 (2012).

15. Wang, Z. et al. Anti-inflammatory properties and regulatory mechanism of a novel derivative of artemisinin in experimental autoimmune encephalomyelitis. Journal of immunology 179, 5958-5965, doi:10.4049/jimmunol.179.9.5958 (2007).

16. Wang, Z. et al. Role of IFN-gamma in induction of Foxp3 and conversion of CD4+ CD25- T cells to CD4+ Tregs. The Journal of clinical investigation 116, 2434-2441, doi:10.1172/JCI25826 (2006).