Personal Introduction

Dr. Qiang Zou received his Ph.D. degree in Microbiology from China Agricultural University in 2012. From 2012 to 2016, he was a postdoctoral fellow at the MD Anderson Cancer Center, USA. In March 2016, he joined the Shanghai Institute of Immunology, School of Medicine, Shanghai Jiao Tong University. The “Cancer Immunometabolism” laboratory has been established to explore the metabolic regulation mechanism of tumor immune response and tolerance, and a series of important academic achievements have been made. Numbers of papers have been published in academic journals such as Nature Cell Biology, Immunity, Cell Metabolism, Cell Host & Microbe, Molecular Cell, Journal of Clinical Investigation, Journal of Experimental Medicine, etc. In recent years, he has presided over a quantity of projects containing: National Science Fund for Distinguished Young Scholars (2022), Key project of National Natural Science Foundation of China(2019, 2024), National Natural Science Funds for Excellent Young Scholar(2019), General project of National Natural Science Foundation of China(2016, 2018), Overseas High-level Talent Introduction scheme Youth program (Organization Department of the CPC Central Committee, 2016), and participated in two National Key Research and Development Program of China(2020, 2021). In 2016, he was selected for the “Early Star Program” of Shanghai Science and Technology Commission; in 2018, he was selected for the “Excellent Youth Program” of Shanghai Health and Family Planning System; in 2018, he was awarded the outstanding Young Scholar Award of the 15th Yangtze River Delta Science and Technology Forum; in 2019, he was awarded the “Young Outstanding Award” of Shanghai Society of Biochemistry and Molecular Biology; and in 2023, he won the second prize of the 19th "Silver Snake Award" of the Shanghai Health and Wellness System. He is councilor of the Chinese Society for Immunology, council member of Free Radical Biology and Free Radical Medicine Branch in Biophysical Society of China. He is also the reviewers for Immunity, Cell Research, Journal of Cell Biology, Communications Biology, FASEB Journal, Protein & Cell, Eur J Immunol, etc.

Office:

• Executive Vice Dean of Shanghai Jiao Tong University College of Basic Medicine Sciences,

• Deputy Director of State Key Laboratory of Oncogenes and Related Genes

Scientific Research Projects

• 82430054, The mechanism and therapeutic strategy of age-related decline in leptin promoting CD8+ T cell dysfunction in the tumor microenvironment, Key Program of National Natural Science Foundation of China, 2025/01~2029/12, 2.30 million yuan, Project director.

• 82225020, Antitumor immunity and glucose metabolism, National Science Fund for Distinguished Young Scholars, 2023/01~2027/12, 4.00 million yuan, Project director.

• 2021YFA1301400, Adaptive immunity basis of individual differences in antiviral immunity. Panoramic study of immune response to respiratory virus infection, National Key Research and Development Program of China, 2021/12~2026/11, 1.47 million yuan, Project participant.

• 2020YFA0803600, Regulation mechanism of metabolic plasticity and memory in tissues and organs and its physiological and pathological significance, National Key Research and Development Program of China, 2020/12~2025/11, 1.45 million yuan, Project participant.

• 81930040, Functions of T cell glucose metabolism in colorectal carcinogenesis, Key Program of National Natural Science Foundation of China, 2020/01~2024/12, 3.00 million yuan, Project director.

• 31922025, Glucose metabolism and antitumor immunity. National Natural Science Funds for Excellent Young Scholar, 2020/01~2022/12, 1.20 million yuan, Project director.

Publications

1. Du X#, Li W#, Li G#, Guo C#, Tang X, Bao R, Li R, Huang H, Xu S, Yu X, Han Q, Wan J, Li S, Sun J, Zhao R, Ye Y, Gao Q*, Ni Z*, Cui X*, & Zou Q *. Diet-derived galactose reprograms hepatocytes to prevent T cell exhaustion and elicit antitumour immunity. Nature Cell Biology, 2025, Aug 8(27): 1357-1366. (IF:19.064)

2. Wan J#, Shi J#, Shi M#, Huang H#, Zhang Z, Li W, Guo C, Bao R, Yu X, Han Q, Du X, Li S, Ye Y, Cui X*, Li X*, Li J*&Zou Q*. Lactate dehydrogenase B facilitates disulfidptosis and exhaustion of tumour-infiltrating CD8+ T cells. Nature Cell Biology, 2025, Jun;27(6):972-982. (IF:19.064)

3. Wang F#, Bao R#, Xu S#, Li W#, Huang H#, Li R#, Ding X, Zhang Y, Yu X, Han Q, Du X, Wan J, Li S, Xiao Y, Zhao R, Cui X, Ye Y*, Sun J*, Zheng J*, Chen G* and Zou Q*. An age-related decrease in leptin contributes to CD8+ T cell aging in the tumor microenvironment. Cell Reports Medicine, 2025, Sep 16;6(9):102310. (IF:11.7)

4. Ding R#, Yu X #, Hu Z #, Dong Y, Huang H, Zhang Y, Han Q, Ni ZY*, Zhao R*, Ye Y* and Zou Q*. Lactate modulates RNA splicing to promote CTLA-4 expression in tumor-infiltrating regulatory T cells. Immunity, 2024, April 9, 57, 1–13. (IF: 32.4)

5. Du X, Jie ZL, and Zou Q. Microbiota alert: Proteobacteria consume arginine to dampen omental antitumor immunity. Cell Host & Microbe, 2024, July10, 32(7), 1045-1047. (IF:20.6)

6. Zhang Y#, Yu X#, Bao R#, Huang H, Gu C, Lv Q, Han Q, Du X, Zhao XY, Ye Y*, Zhao R*, Sun J*, Zou Q*. Dietary fructose-mediated adipocyte metabolism drives antitumor CD8+ T cell responses. Cell Metabolism, 2023 Oct 15:S1550-4131(23)00367-4. (IF: 29.0)

7. Wang A#, Huang H#, Shi JH, Yu X, Ding R, Zhang Y, Han Q, Ni ZY*, Li X*, Zhao R*, Zou Q*. USP47 inhibits m6A-dependent c-Myc translation to maintain regulatory T cell metabolic and functional homeostasis. Journal of Clinical Investigation, 2023 Oct 3:e169365. (IF: 15.9)

8. Hu Z*, Yu X, Ding R, Liu B, Gu C, Pan X, Han Q, Zhang Y, Wan J, Cui X*, Sun J*, Zou Q*. Glycolysis drives STING signaling to facilitate dendritic cell antitumor function. Journal of Clinical Investigation, 2023 Apr 3;133(7):e166031. (IF: 15.9)

9. Wu Z, Huang H, Han Q, Hu Z, Teng XL, Ding R, Ye Y, Yu X*, Zhao R*, Wang Z*, Zou Q*. SENP7 senses oxidative stress to sustain metabolic fitness and antitumor functions of CD8+ T cells. Journal of Clinical Investigation, 2022 Apr 1;132(7):e155224. (IF: 19.456)

10. Wang F, Zhang Y, Yu X, Teng XL, Ding R, Hu Z, Wang A, Wang Z*, Ye Y*, Zou Q*. ZFP91 disturbs metabolic fitness and antitumor activity of tumor-infiltrating T cells. Journal of Clinical Investigation. 2021 Oct 1;131(19):e144318. (IF: 14.808)

11. Hu Z#, Teng XL#, Zhang T, Yu X, Ding R, Yi J, Deng L*, Wang Z*, Zou Q*. SENP3 senses oxidative stress to facilitate STING-dependent dendritic cell antitumor function. Molecular Cell, 2021, Mar 4;81(5):940-952.e5. (IF: 17.970)

12. Wang A#, Ding L#, Wu Z, Ding R, Teng XL, Wang F, Hu Z, Chen L*, Yu X*, Zou Q*. ZFP91 is required for the maintenance of regulatory T cell homeostasis and function. The Journal of Experimental Medicine, 2021 Feb 1;218(2):e20201217. (IF: 14.307)

13. Hu Z#, Qu G#, Yu X#, Jiang H, Teng X-L, Ding L, Hu Q, Guo X, Zhou Y, Wang F, Li H-B, Chen L, Jiang J, Su B*, Liu J*, Zou Q*. Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells. Cell Metabolism, 2019, 30(2):290-302.e5. (IF: 27.287)

14. Yu X#, Teng X-L#, Wang F#, Zheng Y#, Qu G, Zhou Y, Hu Z, Wu Z, Chang Y, Chen L, Li H-B, Su B, Lu L*, Liu Z*, Sun S-C*, Zou Q*. Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome. The Journal of Experimental Medicine, 2018, 215(9):2463-2476. (IF: 14.307)

15. Yu X#, Lao Y#, Teng X-L#, Li S, Zhou Y, Wang F, Guo X, Deng S, Chang Y, Wu X, Liu Z, Chen L, Lu L, Cheng J, Li B, Su B, Jiang J, Li H-B*, Huang C*, Yi J*, Zou Q*. SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation. Nature Communications, 2018, 9:3157. (IF: 14.919)