Personal Introduction

• Dr. Ju Huang received her B.S. degree from Fudan University, School of Medicine in 2006 and her Ph.D. degree from Institute of Neuroscience, Chinese Academy of Sciences in 2011. From 2011 to 2016, she got her postdoc training at Harvard Medical School and then Washington University in St. Louis in the USA. In 2016, Dr. Huang joined Shanghai Jiao Tong University, School of Medicine as the principal investigator and the head of the Laboratory of Innate Behavior and Emotion Regulation.

Research Interest

• Our lab has long been committed to the research of neural-circuit-level and molecular-level mechanisms of innate behavior and emotion regulation, with a series of research achievements in the functional roles of disease-related proteins, epigenetic regulation, and neural circuitry in feeding regulation, thermoregulation, and repetitive behaviors. Our current research work focus on the relationship between innate behaviors and emotion regulation, especially the mechanism mediating the impact of repetitive behaviors on post-stress anxiety-regulation, and the intervention of repetitive behaviors that are associated with neuropsychiatric disorders. We aim to provide a new perspective and insight for our understanding of the neurobiological mechanisms in innate behavior and emotion regulation.

Scientific Research Projects

• "Yangtze River Scholars Award Program" (Young Scholars). (2024.05-2027.04)

• Shanghai University Special Professor (Oriental Scholars) Tracking Program: GZ20220008 (2022.11-2025.10)

• National Key Research and Development Program of China: 2021ZD0202800/01 (2021.12-2026.11)

• National Natural Science Foundation of China: 32070957 (2021.01-2024.12)

• National Natural Science Foundation of China: 32070957 (2021.01-2024.12)

• National Natural Science Foundation of China: 81771215 (2018.01-2021.12)

• Shanghai Brain-Intelligence Project from the Science and Technology Commission of Shanghai Municipality: 18JC1420302 (2018.12-2021.11)

• Program for Professor of Special Appointment (Eastern Scholar for J.H.) at Shanghai Institutions for Higher Learning: 1710000221 (2017.07-2020.06)

• Shanghai Pujiang Talent Program: 17PJ1405300 (2017.07-2019.06)

Publications

1. Di Chen; Yiyu Sun; Laiyang Zhou; Xu Han; Shuo Yang; Feiyang Hong; Yuan Yuan; Xiaohua Wu; Guohui Huang; Yuanchi Cheng; Ju Huang*; Dongfu Feng*. Knockdown of Porf-2 restores visual function after optic nerve crush injury. Cell Death & Disease, 2023, 14(8):570

2. Jingjing Sun; Yuan Yuan; Xiaohua Wu; Anqi Liu; Jingjie Wang; Shuo Yang; Bing Liu;  Yalei Kong; Lizhao Wang; Kai Zhang; Qian Li; Siyu Zhang; Tifei Yuan; Tian-Le Xu; Ju Huang*. Excitatory SST neurons in the medial paralemniscal nucleus control repetitive self-grooming and encode reward. Neuron, 2022, 110(20):3356-3373

3. Shuo Yang; Yu Lin Tan; Xiaohua Wu; Jingjie Wang; Jingjing Sun; Anqi Liu; Linhua Gan; Bo Shen; Xiaocui Zhang; Yu Fu; Ju Huang*. An mPOA-ARC AgRP pathway modulates cold-evoked eating behavior. Cell Reports, 2021, 36(6): 109502

4. Linhua Gan; Jingjing Sun; Shuo Yang; Xiaocui Zhang; Wu Chen; Yiyu Sun; Xiaohua Wu; Cheng Cheng; Jing Yuan; Anan Li; Mark A. Corbett; Mathew P. Dixon; Tim Thomas; Anne K. Voss; Jozef Ge´cz; Guang-Zhong Wang; Azad Bonni; Qian Li; Ju Huang*. Chromatin-binding protein PHF6 regulates activity-dependent transcriptional networks to promote hunger response. Cell Reports, 2020, 30: 3717-3728

5. Sarah Xinwei Luo#; Ju Huang#; Qin Li#; Hasan Mohammad; Chun-Yao Lee; Kumar Krishna; Alison Maun-Yeng Kok; Yu Lin Tan; Joy Yi Lim; Hongyu Li; Ling Yun Yeow; Jingjing Sun; Miao He; Joanes Grandjean; Sreedharan Sajikumar; Weiping Han; Yu Fu*. Regulation of feeding by somatostatin neurons in the tuberal nucleus. Science, 2018, 361: 76-81

6. Ju Huang and Azad Bonni. A decade of the anaphase-promoting complex in the Nervous System. Genes & Development, 2016, 30(6): 622-638

7. Ju Huang; Yoshiho Ikeuchi; Marcos Malumbres; Azad Bonni; A Cdh1-APC/FMRP ubiquitin signaling link drives mGluR-dependent synaptic plasticity in the mammalian brain. Neuron, 2015, 68(3):726-739

8. Ju Huang; Wei Zhang; Wenhui Qiao; Aiqun Hu; Zuoren Wang. Functional Connectivity and Selective Odor Responses of Excitatory Local Interneurons in Drosophila Antennal Lobe. Neuron, 2010,67: 1021-1033