Lab Leader:Fubin Li

Lab Name:Laboratory of Humoral Immunity and Immunotherapy

Lab Info：Our research interest mainly includes: 1) to elucidate how different antibody functions, such as agonism and pathogenicity, are regulated by antibody intrinsic and extrinsic factors, and to develop novel methods to modulate antibody activity based on the understanding of fundamental principles, including strategies for optimizing agnostic cancer immunotherapeutic antibodies; 2) to understand how protective and autoreactive B cell differentiation is regulated, as well as the function of novel B cell subsets, such as CD11c+ age-associated B cells. Our major findings include: (1) Agonistic antibodies require hinge rigidity for immunostimulatory and antitumor activities (Nature Communications 10(1): 4206.); (2) Excessive CD11c+Tbet+ B cells promote aberrant TFH differentiation and affinity-based germinal center selection in lupus (PNAS 116(37):18550-18560.); (3) Pathogenicity of autoantibodies isolated from IgG4-mediated autoimmune diseases is regulated by human IgG constant domain (Elife 11:e76223)

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