Lab Leader: Huabing Li

Lab Name: Laboratory of RNA Epigenetics &Immunity

Lab Info：There are more than 100 types of different chemical RNA modification, among which m6A, m1A, m5C, pseudoUridine and APA are the major ones. HBL lab has made a series of pioneering discoveries in the m6A studies, won international reputations in the field, and laid solid experimental foundation. m6A research has been the frontier of the epigenetics field, but it is under explored for other types of RNA modifications, especially the cross-talks among those RNA modifications in response to environmental stimulation are unknown. Immune cells, especially T cells and macrophages in various inflammatory disease and tumor, provide an ideal perspective to explore this frontier.Combine mouse reverse genetics and state-of-art omics techniques, our research focuses on the following areas:

(1) Function of m1A modification in T cells and macrophages;

(2) Function of pseudouridine modification in T cells and macrophages;

(3) Function of APA modification in T cells and macrophages;

(4) Develop inhibitors to those RNA modification and apply to tumor immunotherapy;

(5) Cross-talks of those RNA modifications.  Our lab website：www.hua-binglilab.com.

Lab Members: