Lab Leader:YAO Yufeng

Lab Name:Laboratory of Bacterial Pathogenesis

Lab Info：

Research interest of the lab:

Our research focuses onbacterial pathogenesis andpathogen-host interactions covering two main topics. The first one is bacterial pathogenesis. UsingSalmonellaTyphimurium,Pseudomonas aeruginosa, and other clinically relevant bacteria as models, we investigate the regulatory roles of protein post-translational modifications (e.g., acetylation,lactylation and methylation) in bacterial virulence, acid resistance, antibiotic tolerance, and intracellular survival. We also useS. Typhimurium as a model to explore the mechanisms by which persister cells contribute to chronic infections and antibiotic resistance. The second topic is the mechanisms of pathogen-host interactions. UsingS. Typhimurium,P. aeruginosaandFusobacterium nucleatum, etc. as models, we investigate how bacteria regulate host protein post-translational modifications (e.g., acetylation and lactylation) and how bacterial metabolites modulate host immunity. This allows us to elucidate the mechanisms by which pathogens influence host cell fate, tumor development and progression, as well as immune responses.

Our group is currently undertaking several projects funded by the National Natural Science Foundation of China, including Youth Programs, General Programs, and Key Programs.Our team consists of one group leader, two associate professors, one senior experimentalist, two postdoctoral fellows, and five graduate students. The group provides its members with a personalized learning and working environment, as well as ample space for future career development. We welcome diligent and dedicated students who are interested in bacterial pathogenesis and human health to applyto join our group.

Lab Members:

Lab Photo: