Lab Leader: Bin Li

Lab Name:Laboratory of Molecular Immunology

Lab Info：Our laboratory focuses on uncovering the molecular mechanisms governing the functional perturbation of FOXP3⁺ regulatory T cells (Tregs) in inflammatory and immune-mediated diseases. We are particularly interested in understanding how these immune cell populations coordinate immune homeostasis across diverse pathological contexts. Our research investigates the role of Tregs in maintaining immune balance in anti-tumor immunity, autoimmune diseases, transplantation tolerance, and anti-infectious immunity. To dissect these mechanisms, we develop and employ Treg-specific depletion models targeting key subunits of the FOXP3 complex, combined with state-of-the-art technologies including single-cell sequencing and immune-metabolic profiling. Using these advanced platforms, we study peripheral tissue-resident Treg cells both in vitro and in vivo under physiological and disease conditions. A central goal of our lab is to translate mechanistic discoveries into personalized therapeutic strategies. We actively explore immunomodulatory approaches such as CAR-Treg–based cell therapy and small-molecule compounds targeting FOXP3, and through these efforts we aim to develop innovative immunotherapies for cancer, autoimmune disorders, and other immune-related diseases. Research from our laboratory has been published in journals such as Nature Immunology (2021), Immunity (2013), Nature Metabolism (2025, 2022), Journal of Clinical Investigation (2025a, 2025b, 2024), Gastroenterology (2021), and Nature Communications (2024, 2016).

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