Lab Leader:Xuefeng Wu

Lab Name:Laboratory of Inflammation and Cancer

Lab Info：Our group focuses on the cellular and molecular mechanisms of inflammatory diseases and cancer.The lab aims to dissect immune cell metabolic regulation networks, composing of oxidative stress, ER stress and endocytosis/autophagy, through unbiased screening or functional validation, we have identified several key regulators that are essential for effector or regulatory T cell fitness, and are investigating therapeutic applications in engineered immune cells in the setting of anti-tumor immunity and autoimmune diseases such as IBD, RA etc.

During the past few years, we have obtained grants from national and Shanghai funding agencies and published research papers in journals including Nature Communications,Journal of Clinical Investigation,Science Advances,Journal of Immunology, European Journal of Immunology, and Theranostics. We have built up strong scientific research atmosphere and harmonious membership. Our group is working together aiming to develop drugs and new strategies for treating patients suffering from immunological diseases and cancers.

Ongoing projects include:

1. Metabolic regulation of macrophage and dendritic cell;

2. Regulation of T/Treg cell antitumor immunity by cellular stress and homeostasis;

3. Regulation of immune responses by cross-talks between immune and tumor cells within Tumor Microenvironments and their function in cancer progression and metastasis.

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