Lab Leader: Jing Zhang

Lab Name: Laboratory of Oxidative Stress Induced Necrosis and Human Diseases

Lab Info：Programmed cell death is crucial for multiple physiological processes of multicellular organisms, and its dysregulation is closely related to a variety of human diseases, such as cancers, neurodegenerative diseases and ischemic diseases. Recent evidence shows that programmed cell death is not only limited to apoptosis, but also necrosic cell death are comprehensively regulated. Therefore, the role and molecular mechanisms of programmed cell death in human diseases and its implications in clinical therapy have always been the focus of our research.

Dr. Jing Zhang's group utilizes biochemistry, molecular and cell biology, model animals, and compound screening to dissect the molecular mechanisms of oxidative stress induced necrotic cell death, and explore its clinical potentials for ischemic diseases and fibrotic diseases. It mainly contains the following aspects:

(1) Post-translational modification in ferroptosis and its effect in liver diseases（Cell Death Differ, 2022）;

(2) The role of ferroptosis in cellular metabolism, cancer metastasis, and cancer therapy.

Lab Members: