Name: Siyu Zhang  

Title： Principal Investigator

Email: Zhang_siyu@sjtu.edu.cn

Tel: +86-15901835404

Research Interests

Top-down attention modulation is a powerful cognitive process allowing selectively processing behaviorally relevant information and filtering out irrelevant stimuli. Studies in human and non-human primates have identified the brain regions involved in top-down attention modulation. However, the neuronal circuits mediating top-down modulation are largely unknown. My long-term goal is to understand the neural mechanisms of attention modulation at the level of the individual neuron and neural circuitry, and to determine how these mechanisms affect behavior. We combine virus-assisted circuit mapping, in vivo and in vitro electrophysiology, in vivo Ca2+ imaging and cell-type-specific optogenetic manipulation to understand neuronal circuit and behavior.

Ten Selected Papers

*co-corresponding authors; #co-first authors

1. Ma, G.#, Liu, Y.#, Wang, L., Xiao, Z., Song, K., Wang, Y., Peng, W., Liu, X., Wang, Z., Jin, S., Tao, Z., Li, C., Xu, T., Xu, F., Xu, M.*, Zhang, S.* Hierarchy in sensory processing reflected by innervation balance on cortical interneurons. Sci. Adv. (2021, in press)

2. Zhang, S.#, Xu, M.#, Chang, W.C., Ma, C., Hoang Do, J. P., Lei, T., Jeong, D., Fan, J.L., Dan,Y.* Organization of long-range inputs and outputs of frontal cortex for top-down control. Nat. Neurosci. 19, 1733-1742 (2016).

3. Zhang, S., Xu, M., Kamigaki, T., Hoang Do, J. P., Chang, W. C., Jenvay, S., Miyamichi, K., Luo, L., Dan, Y.* Long-range and local circuits for top-down modulation of visual cortex processing. Science 345, 660-665 (2014).

4. Zhang, S. Y.#, Xu, M.#, Miao, Q. L., Poo, M. M.*, Zhang, X. H.* Endocannabinoid-dependent homeostatic regulation of inhibitory synapses by miniature excitatory synaptic activities. J. Neurosci. 29, 13222-13231 (2009).

5. Peng, W.#, Wu, Z.#, Song, K.#, Zhang, S, Li, Y., Xu, M.* Regulation of sleep homeostasis mediator adenosine by basal forebrain glutamatergic neurons. Science, 369, 1208 (2020).

6. Hu F., Kamigaki, T., Zhang, Z., Zhang, S., Dan, U., Dan, Y.* Prefrontal Corticotectal Neurons Enhance Visual Processing through the Superior Colliculus and Pulvinar Thalamus. Neuron, 104(6): 1141-1152 (2019).

7. Sun, F.#, Zeng, J.#, Jing, M.#, Zhou, J., Feng, J., Owen, S.F., Luo, Y., Li, F., Wang, H., Yamaguchi, T., Yong, Z., Gao, Y., Peng, W., Wang, L., Zhang, S., Du, J., Lin, D., Xu, M., Kreitzer, A.C., Cui, G., Li, Y.* A Genetically Encoded Fluorescent Sensor Enables Rapid and Specific Detection of Dopamine in Flies, Fish, and Mice. Cell, 174(2): 481-+ (2018).

8. Xu, M.#, Chung, S.#, Zhang, S., Zhong, P., Ma, C., Chang, W., Weissbourd, B., Sakai, N., Luo, L., Nishino, S., Dan, Y.*; Basal forebrain circuit for sleep-wake control. Nat. Neurosci. 18(11): 1641-1647 (2015).

9. Xu, M., Zhang, S., Dan, Y., Poo, M.*; Representation of interval timing by temporally scalable firing patterns in rat prefrontal cortex. PNAS, 111(1): 480-485 (2014).

10. Lee, S.H., Kwan, A.C., Zhang, S., Phoumthipphavong, V., Flannery, J.G., Masmanidis, S.C., Taniguchi, H., Huang, Z.J., Zhang, F., Boyden, E.S., Deisseroth, K., Dan, Y.*; Activation of specific interneurons improves V1 feature selectivity and visual perception. Nature, 488(7411): 379-383 (2012).