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激光显微影像实验室

拥有超高分辨率显微镜、激光共聚焦显微镜和双光子显微镜等八台大型光学显微镜,面向医学院、医院和社会开放,主要开展成像相关的技术服务。

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服务项目

超高分辨率荧光显微镜

应用实例

有丝分裂过程

有丝分裂过程

植物花粉粒三维重构

植物花粉粒三维重构

拟南芥根

拟南芥根

培养的神经元细胞

​培养的神经元细

小鼠脑片标本 标本厚度: 300um

小鼠脑片标本标本厚度: 300u

小鼠胰腺 血管标记 Texas Red–labeled lectin

小鼠胰腺 血管标记Texas Red–labeled lecti

细胞核孔复合体

细胞核孔复合体

小鼠神经元轴突蛋白Alexa594标记

小鼠神经元轴突蛋白Alexa594标记

部分合作文章

1.The role of AGK in thrombocytopoiesis and possible therapeutic strategies .Blood .(2020)

2.Branched-Chain Amino Acid Catabolism Promotes Thrombosis Risk byEnhancing Tropomodulin-3 Propionylation in Platelets. Circulation. (2020)

3.Lgr4 Governs a Pro-Inflammatory Program in Macrophages to Antagonize Post-Infarction Cardiac Repair. Circulation research.(2020)

4.Metabolic imaging reveals a unique preference of symmetric cell division and homing of leukemia-initiating cells in an endosteal niche . Cell Metabolism . (2019)

5.Enhanced Drug Delivery by Nanoscale Integration of a Nitric Oxide Donor To Induce Tumor Collagen Depletion . Nano Lett . (2018)

6.A neuronal molecular switch through cell-cell contact that regulates quiescent neural stem cells . Science Advances . (2018)

7.TRPV1 SUMOylation regulates nociceptive signaling of inflammatory pain. Nat Commun. (2018)

8.JAM3 maintains leukemia-initiating cell self-renewal through LRP5/AKT/β-catenin/CCND1 signaling. J Clin Invest. (2018)

9.Nuclear PTEN safeguards pre-mRNA splicing to link Golgi apparatus for its tumor suppressive role . Nat Commun .(2018)

10.Vacuolar Protein Sorting 33B Is a Tumor Suppressor in Hepatocarcinogenesis. Hepatology. (2018)

11.Neuronal GAP-Porf-2 transduces EphB1 signaling to brake axon growth. Cell Mol Life Sci. (2018)

12.Retrograde regulation of mossy fiber axon targeting and terminal maturation via postsynaptic Lnx1. J Cell Biol. (2018)

13.ASIC1a mediates striatal synapse remodeling and procedural motor learning.Sci Signal. (2018)

14.ASIC1a regulates insular long-term depression and is required for the extinction of conditioned taste aversion. Nat Commun. (2016)

15.Ephrin-B3 coordinates timed axon targeting and amygdala spinogenesis for innate fear behavior.Nat Commun. (2016)

16.A redox mechanism underlying nucleolar stress sensing by nucleophosmin.Nat Commun. (2016)

主要成员

实验室须知

上海交通大学基础医学院基础医学公共技术平台

邮编200025

中国上海重庆南路280号老红楼

021-63846590x776946