当前位置：
陈张朋，博士，研究员
邮箱：zpchen@shsmu.edu.cn;xiaopengczp@163.com
研究方向：癫痫的神经免疫机制与干预
教育经历：
2013-2018，南京大学，生命科学学院生物学系，博士
2009-2013，蚌埠医学院，生命科学系，学士
工作经历：
2024.01-至今，上海交通大学医学院松江研究院，研究员
2023.07-2023.12，南京大学，副研究员
2020.12-2023.07，南京大学，助理研究员
2018.07-2020.12，南京大学，博士后
陈张朋 研究员
癫痫是一种重要的神经疾病，人群发病率约为1%。我国癫痫患者总数近1000万，其中，耐药性癫痫（drug-resistant epilepsy, DRE）患者约占30%，尚无有效的临床药物。课题组采用在体脑电记录，免疫磁珠细胞分选，双光子钙成像，光纤钙记录和膜片钳等神经科学领域前沿技术探究癫痫等重大脑疾病的发生发展机制，我们重点关注颞叶性癫痫和脑中风伴发癫痫症状中胶质细胞与神经元、免疫细胞与胶质细胞互作的机制（Nat Neurosci, 2023；Nat Neurosci, 2024, revised；Neuron, under review）。具体包括但不限于以下三方面研究内容：
1） 研究颞叶性癫痫疾病中胶质细胞和神经元互作及其与癫痫进展之间的关系，以此为突破口寻找抗癫痫治疗的全新靶点；
2） 开展癫痫脑（颞叶性癫痫和脑中风伴发的癫痫等）等重大脑疾病中外周免疫细胞和中枢神经细胞（胶质细胞）互作的机制研究；
3） 外界环境刺激会诱导癫痫发生，其机制尚未明了。我们重点关注声音和光等外界环境刺激诱导癫痫发作的神经环路机制。
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Zhang-Peng Chen#*, Suji Wang#, Xiansen Zhao#, Wen Fang#, Zhengge Wang, Haojie Ye, Mengju Wang, Ling Ke, Tengfei Huang, Pin Lv, Xiaohong Jiang, Qipeng Zhang, Liang Li, Shu-Tao Xie, Jing-Ning Zhu, Chunhua Hang, Dijun Chen*, Xiangyu Liu*, Chao Yan*, Lipid-accumulated reactive astrocytes promote disease progression in epilepsy. Nature Neuroscience, 26(4):542-554, 2023.
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Zhang-Peng Chen, Chao Yan, Research Briefing: Abnormal lipid metabolism shapes astrocyte reactivity in patients with epilepsy. Nature Neuroscience, 26(4):535-536, 2023.
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Zhang-Peng Chen#, Xiao-Yang Zhang#, Shi-Yu Peng, Zhong-Qin Yang, Yan-Bo Wang, Yang-Xun Zhang, Xi Chen, Jian-Jun Wang*, Jing-Ning Zhu*, Histamine H1 receptor contributes to vestibular compensation, Journal of Neuroscience, 39(3):420-433, 2019.
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Yanbo Wang#, Zhang-Peng Chen#, Huanhuan Hu#, Jieqiong Lei#, Zhen Zhou#, Bing Yao, Li Chen, Gaoli Liang, Shoubin Zhan, Xiaoju Zhu, Fangfang Jin, Rujun Ma, Jun Zhang, Hongwei Liang, Ming Xing, Xiao-Rui Chen, Chen-Yu Zhang*, Jing-Ning Zhu*, Xi Chen* Sperm microRNAs confer depression susceptibility to offspring. Science Advances.7:eabd7605, 2021.
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Yi Wang#, Zhang-Peng Chen#, Qian-Xing Zhuang#, Xiao-Yang Zhang, Hong-Zhao Li, Jian-Jun Wang*, Jing-Ning Zhu*, Role of corticotropin-releasing factor in cerebellar motor control and ataxia, Current Biology, 27(17):2661-2669, 2017.
Dispatched by Manto M (2017): Motor control: CRF regulates coordination and gait. Current Biology, 27(17):R847-R850.
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Xin Ding#, Jin Wang#, Miaoxin Huang#, Zhang-Peng Chen#, Jing Liu, Qi-Peng Zhang, Yang Xiang, Cheng-Yu Zhang, Ke Zen*, Liang Li*. Microglial SIRPα negatively regulates synaptic elimination in pathophysiological conditions. Nature Communications, 12(1):2030, 2021.
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Chenwen Shao#, Zhang-Peng Chen#, Chao Yan* and Yong Qian*. 3D tracking of ferrous iron in the epileptic mouse brain and screening of iron homeostasis regulators with a two-photon fluorescent probe. STAR Protocols, 3(3):101522, 2022.
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Ming Hou, Suji Wang, Dandan Yu, Xinyi Lu, Xiansen Zhao, Zhang-Peng Chen*, Chao Yan* Cannabidiol prevents depressive-like behaviors through modulation of neural stem cell differentiation. Frontiers of Medicine, 16(2):227-239, 2022.
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Yi Wang#, Zhang-Peng Chen#, Zhong-Qin Yang#, Xiao-Yang Zhang, Jian-Mei Li, Jian-Jun Wang*, Jing-Ning Zhu*, Corticotropin-releasing factor depolarizes rat lateral vestibular nuclear neurons through activation of CRF receptors 1 and 2. Neuropeptides, S0143-4179 (18):30162-20168, 2019.