Tumor Microenvironment and Preventive Medicine
Research Interests: Extracellular Vesicles and Exosomes, Tumor Metastasis, Microenvironment and Cellular Cross-talk, ceRNA network
Dr. MU’s researches focus on the Tumor Microenvironment and Preventive Medicine, include in the cellular interaction in human microenvironment and the mechanism of tumor formation, metastasis and microenvironment signal regulation.
Exosome/extracellular vesicle-mediated disease microenvironment: The intracellular transport mechanism of exosome was utilized to elucidate the toxic molecular pathway, and the difficulties in tumor metastasis and microenvironment signal regulation were systematically studied.
Toxic effects of environmental pollutants and foodborne diseases: multi-omics analysis of intestinal flora and metabolic pathway study, in-depth elaboration of environmental and food pollutants, food new materials and other toxic mechanisms at molecular, cellular and animal levels;
Signal regulation of non-coding RNA and CeRNA network: By means of systems biology, bioinformatics and molecular biology, the harmful outcome paths of CeRNA network in the occurrence and development of diseases caused by pollutants were comprehensively and systematically explored.
Publications in 3 Years
Mu W, Xu Y, Gu P, Wang WB, Li J, Ge Y*, Wang H*. Exosomal CD44 cooperates with integrin α6β4 to support organotropic metastasis via regulating tumor cell motility and target host cell activation. Engineering, 2021 Oct 7:10 doi.org/10.1016/j.eng.2020.08.013
Ge Y, Gu PF, Cao LY, Li JQ, Mu W*. Benzo[a]pyrene stimulates miR-650 to promote hepatocellular carcinomas metastasis via target SOCS3/JAK/STAT3 cascades J Mol Cell Biol, 2021 Aug 27;13(8):556-564. doi: 10.1093/jmcb/mjab052. (*Corresponding author)
Gu# P, Sun M#, Li L, Yang Y, Jiang Z, Ge Y, Wang WB*, Mu W*, Wang H*. Breast tumor-derived exosomal MicroRNA-200b-3p promotes specific organ metastasis through regulating CCL2 expression in lung epithelial cells. Front Cell Dev Biol. 2021 Jun 24;9:657158. doi: 10.3389/fcell.2021.657158. (*Corresponding author)
Xu Y#, Mu W#, Li J, Ba Q⁎, Wang H⁎. Chronic cadmium exposure at environmental-relevant level accelerates the development of hepatotoxicity to Hepatocarcinogenesis. Sci Total Environ. 2021 Aug 20;783:146958. doi: 10.1016/j.scitotenv.2021. (#Co-first author)
Cao L, Mu W*. Necrostatin-1 and necroptosis inhibition: Pathophysiology and therapeutic implications. Pharmacological Research, 2021, 163, 105297 (*Corresponding author)
Mu W*, Provaznik J, Hackert T, Zoller M*. Tspan8-tumor extracellular vesicle-induced endothelial cell and fibroblast remodeling relies on the target cell-selective response. Cells, 2020, 9: 319 (First author and *Corresponding author)
Ge Y#, Mu W#, Ba, Q, Li JQ, Jiang YG, Xia Q*, Wang H*. Hepatocellular carcinoma-derived exosomes in organotropic metastasis, recurrence and early diagnosis application. Cancer Lett, 2020, 477: 41-48 (#Co-first author)
Mu W, Wang Y, Huang C, Fu YJ, Li JQ, Wang H, Jia XD*, Ba Q*. Effect of long-term intake of dietary Titanium Dioxide nanoparticles on intestine inflammation in Mice. J Agric Food Chem, 2019, 67: 9382-9389
Mu W, Wang Z, Zoller M. Ping-Pong-Tumor and host in pancreatic cancer progression. Front Oncol, 2019, 9,1359
Ge Y, Chen SZ, Mu W, Ba Q, Li JQ, Chen PZ, Wang XM*, Wang H*. Epigenetic regulation of UDP- Glucuronosyltransferase by microRNA-200a/-183: implications for responses to sorafenib treatment in patients with hepatocellular carcinoma. Cancer Lett, 2019, 454: 14-25