Office phone: +86(0)21-63846590-776965
1.Alternative test in toxicology
a)Stem cell toxicology and developmental toxicology
b)Stem cell-derived organoids and their application in toxicity testing
2.Emerging pollutants and their toxic mechanisms in target organs
Shanghai Jiao Tong University, PhD in Public health and predictive medicine
Assistant researcher, Shanghai Jiao Tong University, School of medicine
Postdoctoral fellow, Shanghai Jiao Tong University, School of medicine
2022-2025 Foundation of Shanghai Science and Technology Committee (Specific Program for animal welfare and alternative testing), PI
2020-2023 University Startup Fund, PI
2018-2020 China postdoctoral science foundation, PI
2019-2021 Foundation of Shanghai Science and Technology Committee (Specific Program for animal welfare and alternative testing), participating
2016-2019 National Natural Science Foundation of China, participating
Other professional activities
Reviewer for Theranostics, Environment International, Ecotoxicology and Environmental Safety, Toxicology.
Xie Y, Li Y, Feng Y, Cheng W*, Wang Y*. Inhalable microplastics prevails in air: exploring the size detection limit. Environ Int, 2022, 162:107151.
Cheng W*, Li X, Zhou Y, Yu H, Xie Y, Wang H, Li Y, Feng Y, Wang Y*. Polystyrene microplastics induce hepatotoxicity and disrupt lipid metabolism in the liver organoids. Sci Total Environ, 2022, 806 (Pt 1): 150328.
Cheng W#, Li X#, Yang S, Wang H, Li Y, Feng Y, Wang Y*. Low doses of BPF-induced hypertrophy in cardiomyocytes derived from human embryonic stem cells via disrupting the mitochondrial fission upon the interaction between ERβ and calcineurin A-DRP1 signaling pathway. Cell Biol Toxicol, 2021, doi:10.1007/ s10565-021-09615-y.
Cheng W, Yang S, Li X, Liang F, Zhou R, Wang H, Feng Y, Wang Y*. Low doses of BPA induced abnormal mitochondrial fission and hypertrophy in human embryonic stem cell-derived cardiomyocytes via the calcineurin-DRP1 signaling pathway: A comparison between XX and XY cardiomyocytes. Toxicol Appl Pharmacol.2020, 388:114850.
Cheng W, Yang S, Liang F, Zhou R, Li Y, Feng Y, Wang Y*. Low-dose exposure to triclosan disrupted osteogenic differentiation of mouse embryonic stem cells via BMP/ERK/Smad/Runx-2 signalling pathway. Food Chem Toxicol. 2019, 127:1-10.
Cheng W, Zhou R, Liang F, Wei H, Feng Y, Wang Y*. Application of mouse embryonic stem cell test to detect gender-specific effect of chemicals: a supplementary tool for embryotoxicity prediction. Chem Res Toxicol. 2016,29(9):1519-1533.
Cheng W, Zhou R, Feng Y*, Wang Y*. Mainstream smoke and sidestream smoke affect the cardiac differentiation of mouse embryonic stem cells discriminately. Toxicology. 2016, 357:1-10.
Cheng W, Yu Z, Feng L, Wang Y*. Perfluorooctane sulfonate (PFOS) induced embryotoxicity and disruption of cardiogenesis. Toxicol In Vitro. 2013,27(5):1503-1512.
Li X, Cheng W*, Yang S, Liang F, Wang H, Feng Y, Wang Y*. Establishment of a 13 genes-based molecular prediction score model to discriminate the neurotoxic potential of food relevant-chemicals. Toxicol Lett, 2022, 355:1-18.
Wang L#, Cheng W#, Zhu J#, Li W*, Li D, Fu Q, Mo X, Yang X, Zhao W, Ren M, Ren J, Zhang K*. Electrospun nanoyarn and exosomes of adipose-derived stem cells for urethral regeneration: evaluations in vitro and in vivo. Colloids Surf B Biointerfaces, 2022, 209: 112218.
Zhou R, Cheng W, Feng Y, Wang W, Liang F, F Luo, Yang S, Wang Y*. Combined effects of BPA and PFOS on fetal cardiac development: In vitro and in vivo experiments. Environ Toxicol Pharmacol, 2020, 80: 103434.
Yang S, Cheng W, Li X, Liang F, Zhou R, Wang H, Feng Y, Wang Y*. Use of embryonic stem cell-derived cardiomyocytes to study cardiotoxicity of bisphenol AF via the GPER/CAM/ eNOS pathway.Toxicology, 2020,432:152380.
Zhou R, Cheng W, Wei H, Liang F, Feng Y, Wang Y*. Interactions between three typical endocrine-disrupting chemicals (EDCs) in binary mixtures exposure on myocardial differentiation of mouse embryonic stem cell. Chemosphere. 2017, 178: 378-383.