Research Areas: computational methods in biomedical field
Dr. Zhang received his PhD in Bioinformatics from Fudan University. His research includes novel computational methods, tools and databases in the biomedical field, with a particular focus on the combination of computational methods with specific experimental methods. The main
research fields include: 1. Optimal design of gene editing system based on machine learning/deep learning models; 2. Omic data mining and
knowledge discovery from public database. In the past five years, he has published 9 first-author (including co-authored) SCI papers,obtained 1 patent and 1 software copyright. He had invited to serve as the theme editor of "Frontiers in Genetics".
Hu Z, Zhang C, Wang S, Gao S, Wei J, Li M, et al. Discovery and engineering of small SlugCas9 with broad targeting range and high specificity and activity. Nucleic acids research. 2021;49(7):4008-19.
Hu Z, Zhang C, Wang D, Gao S, Ong S-G, Wang Y, et al. A Highly Sensitive GFP Activation Assay for Detection of DNA Cleavage in Cells. Frontiers in cell and developmental biology. 2021;9:771248-.
Zhang C, Jin X, Chen X, Leng Q, Qiu T. Antigenic evolution on global scale reveals potential natural selection of SARS-CoV-2 by pre-existing cross-reactive T cell immunity. bioRxiv. 2020.
Qiu L, Zhang C, Wu J, Xiong J, Chai J, Luo M, et al. A Retrospective Study of 186 Patients Reveals the Strongest Immunity in the Early Two Years of Life Against Coronavirus Disease 2019. 2020.
Gao N, Zhang C, Hu Z, Li M, Wei J, Wang Y, et al. Characterization of Brevibacillus laterosporus Cas9 (BlatCas9) for mammalian genome editing. Frontiers in cell and developmental biology. 2020:1131.
Wang D, Zhang C, Wang B, Li B, Wang Q, Liu D, et al. Optimized CRISPR guide RNA design for two high-fidelity Cas9 variants by deep learning. Nature communications. 2019;10(1):1-14.
Liu Y, Zhang C, Li L, Ou B, Yuan L, Zhang T, et al. Genome-wide association study of tacrolimus pharmacokinetics identifies novel single nucleotide polymorphisms in the convalescence and stabilization periods of post-transplant liver function. Frontiers in Genetics. 2019;10:528.
Zhang C-D, Yang Y, Chen H-H, Zhang T, Wang Q, Liang Y, et al. RTPDB: a database providing associations between genetic variation or expression and cancer prognosis with radiotherapy-based treatment. Database. 2018;2018.
Song Q, Zhang C-d, Wu X-h. Therapeutic cancer vaccines: From initial findings to prospects. Immunology letters. 2018;196:11-21.
Zhang C, Deng X, Zhang X, Pan Z, Zhao W, Zhang Y, et al. Association between Serum TNF‐α Levels and Recurrent Spontaneous Miscarriage: A Meta‐analysis. American Journal of Reproductive Immunology. 2016;75(2):86-93.