Biography

Dr. Yang Luan received her Ph.D. in 2003 from the Shenyang Pharmaceutical University, China, with the thesis research was performed in Otsuka Research Institute (Japan) by the joint postgraduate training. She worked as a postdoctoral fellow in the Division of Genetics and Mutagenesis of National Institute of Health Sciences (Japan) from 2003 to 2006. She began her scientific career in toxicology in 2006 at the Center for Drug Safety Evaluation and Research, SIMM, Chinese Academy of Sciences (CAS). She joined Shanghai Jiaotong University in 2013. She worked at Division of Genetics and Molecular Toxicology, National Center for Toxicological Research in FDA (USA) as a visiting fellow and in Center for Drug Evaluation, SFDA (China) as a  external scientific expert member in 2012.

Dr. Luan’s research program is focused on utilizing appropriate in vivo and in vitro mutation assays and biological and -omics techniques to provide key toxicological information for exogenous chemicals,including environmental pollutants and herbal medicine, and developing potential biomarkers on genotoxicity, developing new technology on whole genome-widely ultra-low frequencies mutation sequencing.

During her research career, she has published >60 peer-reviewed research articles in scientific journals. She is the editorial board member of SCI magazine of Mutation Research, Mutagenesis, Genes &Environment. She participated in OECD genotoxicity guidelines developing as group member and has been involved the work of international genotoxicity testing expert working group (IWGT) .

Publications

1. Luan, Y., Honma, M. Genotoxicity testing and recent advances. GENOME INSTAB. DIS. 3, 1–21 (2022). https://doi.org/10.1007/s42764-021-00058-7

2. Takeda, S., Luan, Y. Nature of spontaneously arising single base substitutions in normal cells. GENOME INSTAB. DIS. 2, 339–357 (2021).

3. Cao Y, Xi J, Tang C, Yang Z, Liu W, You X, Feng N, Zhang XY, Wu J, Yu Y, Luan Y. PIG-A gene mutation as a genotoxicity biomaker in polycyclic aromatic hydrocarbon-exposed barbecue workers. Genes Environ. 2021 Dec 9;43(1):54. doi: 10.1186/s41021-021-00230-1. PMID: 34879859; PMCID: PMC8656086.

4. Xu L, Gao S, Zhao H, Wang L, Cao Y, Xi J, Zhang X, Dong X, Luan Y. Integrated Proteomic and Metabolomic Analysis of the Testes Characterizes BDE-47-Induced Reproductive Toxicity in Mice. Biomolecules. 2021 May 31;11(6):821. doi: 10.3390/biom11060821. PMID: 34072909; PMCID: PMC8229108.

5. Chen R, You X, Cao Y, Masumura K, Ando T, Hamada S, Horibata K, Wan J, Xi J, Zhang X, Honma M, Luan Y. Benchmark dose analysis of multiple genotoxicity endpoints in gpt delta mice exposed to aristolochic acid I. Mutagenesis. 2021 Apr 28;36(1):87-94. doi: 10.1093/mutage/geaa034. PMID: 33367723.

6. Cao Y, Xi J, You X, Liu W, Luan Y. Dose-response genotoxicity of triclosan in mice: an estimate of acceptable daily intake based on organ toxicity. Toxicol Res (Camb). 2021 Nov 8;10(6):1153-1161. doi: 10.1093/toxres/tfab098. PMID: 34956618; PMCID: PMC8692727.

7. Wan J, Chen R, Yang Z, Xi J, Cao Y, Chen Y, Zhang X, Luan Y. Aristolochic acid IVa forms DNA adducts in vitro but is non-genotoxic in vivo. Arch Toxicol. 2021 Aug;95(8):2839-2850. doi: 10.1007/s00204-021-03077-1. Epub 2021 Jul 5. PMID: 34223934.

8. Cao Y, Wang X, Liu W, Feng N, Xi J, You X, Chen R, Zhang X, Liu Z, Luan Y. The potential application of human PIG-A assay on azathioprine-treated inflammatory bowel disease patients. Environ Mol Mutagen. 2020 Apr;61(4):456-464. doi: 10.1002/em.22348. Epub 2019 Dec 6. PMID: 31743483.

9. Cao Y, Wang T, Xi J, Zhang G, Wang T, Liu W, You X, Zhang X, Xia Z, Luan Y. PIG-A gene mutation as a genotoxicity biomarker in human population studies: An investigation in lead-exposed workers. Environ Mol Mutagen. 2020 Jul;61(6):611-621. doi: 10.1002/em.22373. Epub 2020 Apr 27. PMID: 32285465.

10. Wang T, Tu Y, Wang K, Gong S, Zhang G, Zhang Y, Meng Y, Wang T, Li A, Cui J, Liu H, Tang W, Xi J, Cao Y, Luan Y, Christiani DC, Au W, Xia ZL. Associations of blood lead levels with multiple genotoxic biomarkers among workers in China: A population-based study. Environ Pollut. 2020 Nov 30;273:116181. doi: 10.1016/j.envpol.2020.116181. Epub ahead of print. PMID: 33508628.

11. You X, Thiruppathi S, Liu W, Cao Y, Naito M, Furihata C, Honma M, Luan Y, Suzuki T. Detection of genome-wide low-frequency mutations with Paired-End and Complementary Consensus Sequencing (PECC-Seq) revealed end-repair-derived artifacts as residual errors. Arch Toxicol. 2020 Oct;94(10):3475-3485. doi: 10.1007/s00204-020-02832-0. Epub 2020 Jul 31. PMID: 32737516.

12. Pfuhler S, van Benthem J, Curren R, Doak SH, Dusinska M, Hayashi M, Heflich RH, Kidd D, Kirkland D, Luan Y, Ouedraogo G, Reisinger K, Sofuni T, van Acker F, Yang Y, Corvi R. Use of in vitro 3D tissue models in genotoxicity testing: Strategic fit, validation status and way forward. Report of the working group from the 7th International Workshop on Genotoxicity Testing (IWGT). Mutat Res Genet Toxicol Environ Mutagen. 2020 Feb-Mar;850-851:503135. doi: 10.1016/j.mrgentox.2020.503135. Epub 2020 Jan 15. PMID: 32247552.

13. Chen R, Zhou C, Cao Y, Xi J, Ohira T, He L, Huang P, You X, Liu W, Zhang X, Ma S, Xie T, Chang Y, Luan Y. Assessment of Pig-a, Micronucleus, and Comet Assay Endpoints in Tg.RasH2 Mice Carcinogenicity Study of Aristolochic Acid I. Environ Mol Mutagen. 2020 Feb;61(2):266-275. doi: 10.1002/em.22325. Epub 2019 Sep 30. PMID: 31443125.

14. Liu W, Xi J, Cao Y, You X, Chen R, Zhang X, Han L, Pan G, Luan Y. An Adaption of Human-Induced Hepatocytes to In Vitro Genetic Toxicity Tests. Mutagenesis. 2019 May 29;34(2):165-171. doi: 10.1093/mutage/gey041. PMID: 30590776.

15. Xu H, Feng C, Cao Y, Lu Y, Xi J, Ji J, Lu D, Zhang XY, Luan Y. Distribution of the parent compound and its metabolites in serum, urine, and feces of mice administered 2,2',4,4'-tetrabromodiphenyl ether. Chemosphere. 2019 Jun;225:217-225. doi: 10.1016/j.chemosphere.2019.03.030. Epub 2019 Mar 8. PMID: 30877916.

16. Wu WJ, Tang WF, Xiang MH, Yan J, Cao X, Zhou CH, Chang Y, Xi J, Cao YY, Luan Y, Zhang XY. Isotope dilution LC/ESI--MS-MS quantitation of urinary 1,4-bis(N-acetyl-S-cysteinyl)-2-butanone in mice and rats as the biomarker of 1-chloro-2-hydroxy-3-butene, an in vitro metabolite of 1,3-butadiene. Chem Biol Interact. 2019 Sep 25;311:108760. doi: 10.1016/j.cbi.2019.108760. Epub 2019 Jul 23. PMID: 31348916.

17. Luan Y, Ma S, Mao Y. Is it really the "dark side" of herbal medicine? Sci China Life Sci. 2018 Sep;61(9):1118-1119. doi: 10.1007/s11427-018-9351-0. Epub 2018 Aug 3. PMID: 30076563.

18. Wang Y, Yu YX, Luan Y, An J, Yin DG, Zhang XY. Bioactivation of 1-chloro-2-hydroxy-3-butene, an in vitro metabolite of 1,3-butadiene, by rat liver microsomes. Chem Biol Interact. 2018 Feb 25;282:36-44. doi: 10.1016/j.cbi.2018.01.006. Epub 2018 Jan 10. PMID: 29329665.

19. You X, Ando T, Xi J, Cao Y, Liu W, Zhang X, Honma M, Masumura K, Luan Y. Gene mutation and micronucleus assays in gpt delta mice treated with 2,2',4,4'-tetrabromodiphenyl ether. Mutagenesis. 2018 Apr 13;33(2):153-160. doi: 10.1093/mutage/gey002. PMID: 29462428.

20. You X, Xi J, Liu W, Cao Y, Tang W, Zhang X, Yu Y, Luan Y. 2,2',4,4'-tetrabromodiphenyl ether induces germ cell apoptosis through oxidative stress by a MAPK-mediated p53-independent pathway. Environ Pollut. 2018 Nov;242(Pt A):887-893. doi: 10.1016/j.envpol.2018.07.056. Epub 2018 Jul 19. PMID: 30041162.

21. Wei Z, Xi J, Gao S, You X, Li N, Cao Y, Wang L, Luan Y, Dong X. Metabolomics coupled with pathway analysis characterizes metabolic changes in response to BDE-3 induced reproductive toxicity in mice. Sci Rep. 2018 Apr 3;8(1):5423. doi: 10.1038/s41598-018-23484-2. PMID: 29615664; PMCID: PMC5882662.

22. You X, Xi J, Cao Y, Zhang J, Luan Y. 4-Bromodiphenyl Ether Induces Germ Cell Apoptosis by Induction of ROS and DNA Damage in Caenorhabditis elegans. Toxicol Sci. 2017 Jun 1;157(2):510-518. doi: 10.1093/toxsci/kfx064. Erratum in: Toxicol Sci. 2017 Jul 1;158(1):240. PMID: 28369609.

23. Wang L, Xu W, Ma L, Zhang S, Zhang K, Ye P, Xing G, Zhang X, Cao Y, Xi J, Gu J, Luan Y. Detoxification of benzo[a]pyrene primarily depends on cytochrome P450, while bioactivation involves additional oxidoreductases including 5-lipoxygenase, cyclooxygenase, and aldo-keto reductase in the liver. J Biochem Mol Toxicol. 2017 Jul;31(7). doi: 10.1002/jbt.21902. Epub 2017 Jan 23. PMID: 28111842.