Department of Environment and Health
Department of Environment and Health

1CF15

XIE HeHui

Professor

Email: xhhtom@263.net

Tel: 13918233755

Educational Background

  • 1995     B.S. Shanghai Medical University, China

  • 1999     M.S. Fujian Medical University, China

  • 2003     Ph.D Second Military Medical University, China

Professional Experience

  • 1995.07 – 2000.07 Teaching Assistant, Department of Pharmacology, Fujian Medical University, China

  • 2003.07 – 2008.09 Lecturer, Department of Pharmacology, Second Military Medical University, China

  • 2006.09 – 2008.04 Research Associate, Department of Pharmacology and Toxicology, Michigan State University, USA

  • 2008.09 – 2015.12 Associate Professor, Department of Pharmacology, Second Military Medical University, China

  • 2016.01 – 2017.11 Associate Professor, School of Public health, Shanghai Jiao Tong University School of Medicine, China

  • 2017.12 – present Professor, School of Public health, Shanghai Jiao Tong University School of Medicine, China

Honors and Awards

  • 2006The Tenth Servier Prize by the Chinese Pharmacological Society

  • 2006Natural Science Award (Second-class honour) by the science & technology committee of Shanghai municipal government, China

  • 2009    National Natural Science Award (Second-class honour), China

Research Interests

Stroke is a devastating disease and the major cause of mortality and morbidity worldwide. The integrity and function of the endothelium plays an important role in the prevention of cerebrocardiovascular diseases, such as stroke. Endothelial progenitor cells (EPC) are immature cells that can differentiate into mature endothelial cells and could be recruited from bone marrow to the injury site to promote endothelial regeneration and neovascularization. In addition, EPCs have been used to successfully improve function recovery in ischemic organs, including brain after ischemic injury. Recent reports showed that EPC may serve as a new marker for stroke outcomes. This research group aims to investigate the effect of environmental factors on cerebrocardiovascular diseases, and determine their mechanisms focusing on endothelial and EPC function.

Research Projects

NSFC 82070266 (Xie, H.H., PI)       01/01/21 – 12/31/24

  • National Natural Science Foundation of China

  • Mild cold exposure promotes cerebrovascular injury repair and its mechanism in diabetic mice

NSFC 81870189 (Xie, H.H., PI)       01/01/19 – 12/31/22

  • National Natural Science Foundation of China

  • Long-term intake of sugar substitutes aggravates cerebral ischemic injury and its mechanism in mice

NSFC 81370253 (Xie, H.H., PI)       01/01/14 – 12/31/17

  • National Natural Science Foundation of China

  • Sodium dichloroacetate enhances diabetic endothelial progenitor cell function and it's application in cerebral ischemic injury treatment in diabetic mice

NSFC 81170115 (Xie, H.H., PI)       01/01/12 – 12/31/15

  • National Natural Science Foundation of China

  • Endothelial progenitor cell dysfunction induced by MnSOD deficiency aggravate cerebral ischemic injury in mice

NSFC 30971158 (Xie, H.H., PI)       01/01/10 – 12/31/12

  • National Natural Science Foundation of China

  • TSP-1-related mechanisms underlying the dysfunction of endothelial progenitor cells in low-renin hypertensive mice

NSFC 30700307 (Xie, H.H., PI)       01/01/08 – 12/31/10

  • National Natural Science Foundation of China

  • Oxidative stress and the reduction of endothelial progenitor cells in DOCA-salt hypertensive mice

Publications

  1. Xie HH, Miao CY, Liu JG, Su DF. Importance of blood pressure variability in the organ protection in spontaneously hypertensive rats treated with combination of nitredipine and atenolol. Acta Pharmacol Sin 2002; 23: 1199-204.

  2. Miao CY, Xie HH, Wang JJ, Su DF. Candesartan inhibits sinoaortic denervation -induced cardiovascular hypertrophy in rats. Acta Pharmacol Sin 2002; 23: 713-20.

  3. Lu ZA, Xie HH, Xu LP, Yin AF, Miao CY, and Su DF. Restoration of arterial baroreflex function contributes to organ protection in spontaneously hypertensive rats treated with long-term hydrochlothiazide mixture. Clin Exp Pharmacol physiol 2003; 30: 49-54.

  4. Xie HH, Miao CY, Liu JG, and Su DF. Effects of Long-Term Treatment with Candesartan on Organ Damages in Sinoaortic Denervated Rats. J Cardiovasc Pharmacol 2003; 41: 325-31.

  5. Miao CY, Xie HH, Yu H, Chu ZX, Su DF. Ketanserin stabilizes blood pressure in conscious spontaneously hypertensive rats. Clin Exp Pharmacol physiol 2003; 30: 189-93.

  6. Zhang C, Chen H, Xie HH, Shu H, Yuan WJ, Su DF. Inflammation is involved in the organ damage induced by sinoaortic denervation in rats. J Hypertens. 2003; 21: 2141-8.

  7. Cai GJ, Li L, Xie HH, Xu JJ, Miao CY, Su DF. Morphological evidence of reinnervation of the baroreceptive regions in sinoaortic-denervated rats. Clin Exp Pharmacol Physiol. 2003; 30: 925-9.

  8. Su DF, Xu LP, Miao CY, Xie HH, Shen FM, Jiang YY. Two useful methods for evaluating antihypertensive drugs in conscious freely moving rats. Acta Pharmacol Sin. 2004; 25: 148-51.

  9. Zhang C, Xie HH, Lu ZA, Zhu MJ, Su DF. Inhibition of inflammation contributes to organ protection of atenolol in sinoaortic-denervated rats. J Cardiovasc Pharmacol. 2004; 43: 663-8.

  10. Miao CY, Xu LP, Liu JG, Xie HH, Yuan WJ, Su DF. Frequent ventricular premature beats increase blood pressure variability in rats. Acta Pharmacol Sin. 2004; 25: 545-53.

  11. Shen FM, Guan YF, Xie HH, Su DF. Arterial baroreflex function determines the survival time in lipopolysaccharide-induced shock in rats. Shock. 2004; 21: 556-60.

  12. Miao CY, Cai GJ, Tao X, Xie HH, Su DF. Greater hypertrophy in right than left ventricles is associated with pulmonary vasculopathy in sinoaortic-denervated wistar-kyoto rats. Clin Exp Pharmacol Physiol. 2004; 31: 450-5.

  13. Xie HH, Miao CY, Jiang YY, Su DF. Synergism of atenolol and nitrendipine on hemodynamic amelioration and organ protection in hypertensive rats. J Hypertens 2005; 23: 193-201.

  14. Xie HH, Shen FM, Cao YB, Li HL, Su DF. Effects of low-dose ketanserin on blood pressure variability, baroreflex sensitivity and end-organ damage in spontaneously hypertensive rats. Clin Sci (Lond) 2005; 108: 547-52.

  15. Cai GJ, Miao CY, Xie HH, Lu LH, Su DF. Arterial baroreflex dysfunction promotes atherosclerosis in rats. Atherosclerosis. 2005; 183(1): 41-7.

  16. Wang DS, Xie HH, Shen FM, Cai GJ, Su DF. Blood pressure variability, cardiac baroreflex sensitivity, and end organ damage in experimentally hypertensive rats. Clin Exp Pharmacol Physiol 2005; 32: 545-52.

  17. Xie HH, Shen FM, Miao CY, Su DF. Blood pressure, baroreflex sensitivity and end organ damage in hybrid offspring of SHR and SD rats. Acta Pharmacol Sin 2005; 26: 1049-56.

  18. Shen FM, Xie HH (co-first author), Ling G, Xu LP, SU DF. Synergism of atenolol and amlodipine on lowering and stabilizing blood pressure in 2K1C renovascular hypertensive rats. Acta Pharmacol Sin 2005; 26: 1303-8.

  19. Lu LH, Xie HH, Cai GJ, Shen FM, Su DF. Diminished responses to nifedipine imply severe end-organ damage in spontaneously hypertensive rats. J Cardiovasc Parmacolol 2005; 46: 836-41.

  20. Xie HH, Chen YY, Miao CY, Shen FM, Su DF. Effects of long-term treatment with candesartan on hemodynamics and organ damage in spontaneously hypertensive rats. Cardiovasc Drugs Ther 2005; 19: 391-7.

  21. Shen FM, Zhang SH, Xie HH, Su DF. Early structural changes of aortic wall in sinoaortic denervated rats. Clin Exp Pharmacol Physiol 2006; 33: 358-63.

  22. Miao CY, Xie HH, Zhan LS, Su DF. Blood pressure variability is more important than blood pressure level in determination of end-organ damage in rats. J Hypertens 2006; 24: 1137-46.

  23. Gu XW, Xie HH, Wang J, Shen FM, Su DF. Arterial baroreflex is not involved in salt preference in rats. Clin Exp Pharmacol Physiol 2006; 33: 607-11.

  24. Xie HH, Shen FM, Zhang XF, Jiang YY, Su DF. Blood pressure variability, baroreflex sensitivity and organ damage in spontaneously hypertensive rats treated with various antihypertensive drugs. Eur J Pharmacol 2006; 543: 77-82.

  25. Han P, Chu ZX, Shen FM, Xie HH, Su DF. Synergism of hydrochlorothiazide and nitrendipine on reduction of blood pressure and blood pressure variability in spontaneously hypertensive rats. Acta Pharmacol Sin. 2006; 27: 1575-9.

  26. Li M, Wang J, Xie HH, Shen FM, Su DF. The susceptibility of ventricular arrhythmia to aconitine in conscious Lyon hypertensive rats. Acta Pharmacol Sin. 2007; 28: 211-5.

  27. Xie HH, Shen FM, Xu LP, Han P, Miao CY, Su DF. Reduction of blood pressure variability by combination therapy in spontaneously hypertensive rats. J Hypertens 2007; 25: 2334–44.

  28. Xie HH, Zhang XF, Chen YY, Shen FM, Su DF. Synergism of Hydrochlorothiazide and Nifedipine on Blood Pressure Variability Reduction and Organ Protection in Spontaneously Hypertensive Rats. Hypertens Res 2008; 31: 685–691.

  29. Han P, Shen FM, Xie HH, Chen YY, Miao cy, Mehta JL, Sassard J, Su DF. The combination of atenolol and amlodipine is better than their monotherapy for preventing end-organ damage in different types of hypertension in rats. J Cell Mol Med 2009; 13: 726-734.

  30. Xie HH, Zhou S, Chen D, Channon KM, Su DF, Chen AF. GTP cyclohydrolase I/BH4 pathway protects EPCs via suppressing oxidative stress and thrombospondin-1 in salt-sensitive hypertension. Hypertension 2010;56:1137-1144

  31. Yu YS, Xie HH, Li L, Song SW, Han P, Cai GJ, Su DF. Effects of low-dose ketanserin on atherosclerosis in rats and rabbits. Can J Physiol Pharmacol. 2010; 88: 1054-1060

  32. Ni M, Yang ZW, Li DJ, Li Q, Zhang SH, Su DF, Xie HH (Co-corresponding author), Shen FM. A potential role of alpha-7 nicotinic acetylcholine receptor in cardiac angiogenesis in a pressure overload rat model. J Pharmacol Sci 2010; 114: 311-319

  33. Shang W, Han P, Yang CB, Gu XW, Xu LP, Fu ST, Su DF, Xie HH (Corresponding author). Synergism of irbesartan and amlodipine on hemodynamic amelioration and organ protection in spontaneously hypertensive rats. Acta Pharmacol Sin. 2011; 32: 1109-1115.

  34. Ma J, Peng C, Guo W, Dong YF, Dong XH, Sun X, Xie HH (Corresponding author). A modified model of middle cerebral artery electrocoagulation in mice. CNS Neurosci Ther 2012; 18: 796-798.

  35. Liu F, Chen DD, Sun X, Xie HH, Yuan H, Jia W, Chen AF. Hydrogen Sulfide Improves Wound Healing via Restoration of Endothelial Progenitor Cell Functions and Activation of Angiopoietin-1 in Type 2 Diabetes. Diabetes. 2014; 63: 1763-78.

  36. Tie L, Chen LY, Chen DD, Xie HH, Channon KM, Chen AF. GTP Cyclohydrolase I Prevents Diabetic Impaired Endothelial Progenitor Cells and Wound Healing by Suppressing Oxidative Stress/Thrombospondin-1. Am J Physiol Endocrinol Metab 2014; 306: E1120-31.

  37. Dong XH, Sun X, Jiang GJ, Chen AF, Xie HH (Corresponding author). Dietary intake of sugar substitutes aggravates cerebral ischemic injury and impairs endothelial progenitor cells in mice. Stroke 2015; 46: 1714-18.

  38. Jiang Y, Wang LP, Dong XH, Cai J, Jiang GJ, Zhang C, Xie HH. Trace amounts of copper in drinking water aggravate cerebral ischemic injury via impairing endothelial progenitor cells in mice. CNS Neurosci Ther 2015; 21: 677-80.

  39. Wang LP, Jiang Y, Yang H, Peng C, Zhang C, Tao X, Xie HH (Corresponding author). Combination therapy of nifedipine and sulphonylureas exerts a mutual antagonistic effect on the endothelial cell dysfunction induced by hyperglycaemia linked to vascular disease. Cell Physiol Biochem 2016; 38: 2337-2347.  

  40. Xin B, Liu CL, Yang H, Peng C, Dong XH, Zhang C, Chen AF, Xie HH (Corresponding author). Prolonged fasting improves endothelial progenitor cell-mediated ischemic angiogenesis in mice. Cell Physiol Biochem 2016; 40: 693-706.  

  41. Dong XH, Peng C, Zhang YY, Tao YL, Tao X, Zhang C, Chen AF, Xie HH (Corresponding author). Chronic exposure to subtherapeutic antibiotics aggravates ischemic stroke outcome in mice. EBiomedicine 2017; 24: 116-126.

  42. Peng C, Wang LP, Tao X, Dong XH, Xu CF, Jiang Y, Liu CL, Ma HF, Zhang C, Chen AF, Xie HH (Corresponding author). Preventive cold acclimation augments the reparative function of endothelial progenitor cells in mice. Cell Physiol Biochem 2018; 45: 175-191.  

  43. Peng C, Dong XH, Liu JL, Tao YL, Xu CF, Wang LP, Liu CL, Su DF, Tao X, Zhang C, Chen AF, Xie HH (Corresponding author). A Preventive Injection of Endothelial Progenitor Cells Prolongs Lifespan in Stroke-prone Spontaneously Hypertensive Rats. Clin Sci (Lond) 2018; 132: 1797–1810.

  44. Zhu J, Chen C, Lu D, Zhang J, Jing S, Xie H, Zhang J. Aspirin use during pregnancy and hypertensive disorders in women with various risks. Pregnancy Hypertens 2019; 17: 241-248.

  45. Dong XH, Peng C, Zhang YY, Jiang Y, Yang LJ, He JB, Tao X, Zhang C, Chen AF, Xie HH (Corresponding author). Low-dose piperlongumine rescues impaired function of endothelial progenitor cells and reduces cerebral ischemic injury in high-fat diet-fed mice. Front Pharmacol 2021; 12: 689880.

No. 227 South Chongqing  Road, Shanghai, China   200025   021-63846590

Shanghai ICP No. 0505204  Shanghai Public Network Security No. 31009102000047

Copyright © 2017 Shanghai Jiao Tong University School of Medicine