LI Fei

MD., Ph.D.



Work Affiliation: Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Address: 1665 Kongjiang Road, Shanghai, 200092,China

Current Assignment

  • Chief Physician, Professor of Pediatrics, Doctoral Advisor

  • NSFC Distinguished Young Scholar, NSFC Excellent Young Scholar, Shanghai Dawn Scholar, Shanghai Pujiang Scholar, Shanghai Leading Talent, Shanghai Outstanding Academic Leader

  • Vice President, Xinhua Children’s Hospital Affiliated to Xinhua Hospital

  • Director, Department of Developmental and Behavioral Pediatric &Child Primary Care, Xinhua Hospital.

  • Vice Director, MOE-Shanghai Key Laboratory of Children's Environmental Health.    

  • Vice Chair, Developmental and Behavioral Pediatric Youth Committee of Chinese Medical Society

  • Standing Committee Member, Autism Spectrum Disorder Group, Pediatric Rehabilitation Committee of China Association Rehabilitation Medicine

  • Standing Committee Member, Committee of Applied Behavior Analysis, China Association of Rehabilitation of Disabled Persons

  • Senior Mentor, International Society for Autism Research (INSAR)

  • Committee Member, Clinical Drug Development Committee, The International College of Neuropsychopharmacology (CINP)

Biographical Sketch

Dr. Fei Li completed two postdoctoral trainings in developmental behavioral pediatrics and cognitive neurobiology respectively. As a senior visiting scholar, she worked at Harvard University Boston Children's Hospital and Wisconsin Children's Hospital, focusing on children's cognitive and behavioral problems. She has rich experience in clinical practice, as well as in the three-level prevention and treatment of Autistic Spectrum Disorder (ASD), Attention Deficit and Hyperactivity Disorder (ADHD), and their common comorbidities (such as eating disorders, obesity). Meanwhile targeting at the clinical barriers of these neurodevelopmental disorders, she carries out translation-driven scientific research with multidisciplinary approaches, such as neuroimaging, neurotoxicology, epidemiology, nutrition and so on. She has identified a series of risk factors of these disorders, illustrated their exposure-outcome mechanisms, found out biomarkers for early detection and intervention, and actively established and implemented a set of novel intervention programs based on the principle of “integration of medicine and prevention”.

In the last few years, Dr. Fei Li published up to 25 SCI papers as the first or corresponding author. Her research results were published on the high-profile journals in the neuroscience, psychiatry and pediatrics fields, such as Nature Communication, American Journal of Psychiatry, Molecular Psychiatry, Science Bulletin and Pediatrics, which were frequently cited by the top journals in the areas of neuroscience and medicine, including Trends in Neurosciences, American Journal of Psychiatry. The highest citation of a single article is 332 (google scholar). The findings from her group have been collected in the Chinese Clinical Guidelines of ADHD, international textbook - Clinical Neuropsychology, the SAGE Handbook series; it also provided strong scientific evidence and has contributed to the updated policy statement of Apgar score in American Academy of Pediatrics Committee (APP) and American College of Obstetricians and Gynecologists Committee on Obstetric Practice (ACOG). She was invited to draft the Chinese Clinical Guidelines of ADHD and to write previews in New England Journal of Medicine. She was invited to give keynote speeches at the World Congress on ADHD and the International Neuropsychopharmacology World Congress, she was served as co-executive chairman and gave keynote speech at Xiangshan Conference -Innovative Exploration of Autism and Alzheimer. In addition, she was awarded as NSFC Distinguished Young Scholar, NSFC Excellent Young Scholar, Outstanding Youth Post Expert, Shanghai Dawn Scholar, Shanghai Outstanding Academic Leader, the Medical Tree Award-Clinical Innovation Category, and the Honorable Doctor of China - Young Talent.

Research Experience

  • Principal Investigator, MOE-Shanghai Key Laboratory of Children's Environmental Health, 2010-Research interest: I. translational research of neurodevelopment disorders

    II. gene-environmental interaction on childhood neurodevelopmental outcomes

  • Co-Principal Investigator, Shanghai Key Laboratory of Brain Functional Genomics, East China Normal University, 2014 -

  • Research interest: neurological mechanisms of neurodevelopment disorders

  • Distinguished professor, the Institute of Science and Technology for Brain-inspired Intelligence,Fudan University, 2016 -

  • Research interest: big data analytics for neuropsychiatric disorders

  • Postdoctoral Fellow, Medical College of Georgia (now Georgia Regents University), 2007-2009 Mentor: Joe Tsien; Research interest: molecular mechanism of learning and memory

  • Postdoctoral Fellow, Boston University Medical Campus, 2007- 2007                                  Mentor: Joe Tsien; Research interest: molecular mechanism of learning and memory

  • Postdoctoral Fellow, Shanghai Jiao Tong University School of Medicine, 2004-2006                Mentor: Xiaoming Shen; Research interest: gene-environmental interaction on childhood neurodevelopmental outcomes

Clinical Experience

  • Chief Physician, Department of Developmental and Behavioral Pediatric & Child Health Care, Xinhua Hospital, 2016-

  • Chief Physician, Developmental and Behavioral Pediatric Department, Shanghai Children's Medical Center, 2014-2016

  • Vice-chief Physician, Developmental and Behavioral Pediatric Department, Shanghai Children’s Medical Center, 2010-2014

  • Attending physician, Resident Physician, Developmental and Behavioral Pediatric Department, Shanghai Children's Medical Center, 2006-2009

  • Special clinical interest: ADHD, ASD, feeding difficulties, language disorder, and mental retardation.

Grants in recent 5 years (as principal investigator)

  1. The National Science Foundation for Distinguished Young Scholars (82125032), 2022.01.01-2026.12.31

  2. The National Natural Science Foundation of China – Key Project (81930095), 2020.1-2024.12

  3. Shanghai Municipal Science and Technology Major Project (Autism Sub-project) (2018SHZDZX01), 2018.7 – 2023.6

  4. The National Natural Science Foundation of China – Key Projects of China-Canada International Cooperation (81761128035), 2018.1-2022.12

  5. Shanghai Science and Technology Commission – Key Project1(9410713500), 2019.04-2022.03

  6. Program of Shanghai Pediatrics Subject Chief Scientist (17XD1403200), 2017.01-2019.12

  7. Plateau Peak Plan of Shanghai Jiao Tong University School of Medicine (Research Physician Project) (20152234), 2016.01-2019.12

  8. The Natural Science Foundation of China – General Project (81571031), 2016.1-2018.12

Selective Publications

  1. Shen C#,Luo Q#*,Jia T, Zhao Q,…,Robert Whealan,Li F*,Feng JF*,Schumann G,Sahakian B, for the IMAGEN consortium, Neural correlates of the dual-pathway model for ADHD in adolescents. Am J Psychiatry. 2020 Sep 1;177(9):844-854. doi:10.1176/appi.ajp. 2020.19020183.

  2. Yan Y#, Zhang L#, Zhu T#, Deng S, Ma B, Lv H, Shan X, Cheng H, Jiang K, Zhang T, Meng B, Mei B*, Li WG*, Li F*. Reconsolidation of a post-ingestive nutrient memory requires mTOR in the central amygdala. Mol Psychiatry. 2020 Sep 1. doi: 10.1038/s41380-020-00874-5.

  3. Yuan D#, Zhang L#, Yu J#, …, Sahakian BJ, Luo Q*, Li F*. Improved symptoms following bumetanide treatment in children aged 3 to 6 years with autism spectrum disorder: A randomized, double-blind, placebo-controlled trial. Science Bulletin. 2021. https://doi.org/10.1016/j.scib.2021.01.008.

  4. Yang K#, Shi Y#, Du X#, Wang J, Zhang Y, Shan S, Yuan Y, Wang R, Zhou C, Liu Y, Cai Z, Wang Y, Fan L, Xu H, Yu J, Cheng J, Li F*, Qiu Z*. SENP1 in the retrosplenial agranular cortex regulates core autistic-like symptoms in mice. Cell Rep. 2021 Nov 2;37(5):109939. doi: 10.1016/j.celrep.2021.109939. PMID: 34731627.

  5. Shi K#, Zhang L#, Yu J#, …, Feng JF, Bork P, Zhao XM*, and Li F*. A 12-genus bacterial signature identifies a group of severe autism children with differential sensory behavior and brain structures. Clinical and Translational Medicine.2021(Accepted).

  6. Wang H#, Rolls ET#, Du X, Du J, Yang D, Li J, Li F*, Cheng W*, Feng J. Severe nausea and vomiting in pregnancy: psychiatric and cognitive problems and brain structure in children. BMC Med. 2020 Sep 1;18(1):228. doi: 10.1186/s12916-020-01701-y.

  7. Luo Q#, Zhang L#, Huang CC#, Zheng Y, Kanen JW, …, Sahakian BJ, Schumann G, Li F*, Feng J*, Desrivières S#, Robbins TW; IMAGEN consortium. Association between childhood trauma and risk for obesity: a putative neurocognitive developmental pathway. BMC Med. 2020 Oct 15;18(1):278. doi: 10.1186/s12916-020-01743-2.

  8. Zhang L#, Huang CC#, Dai Y#, Luo Q*, Ji Y, Wang K, Deng S, Yu J, Xu M, Du X, Tang Y, Shen C, Feng J, Sahakian BJ, Lin CP*, Li F*. Symptom improvement in children with autism spectrum disorder following bumetanideadministration is associated with decreased GABA/glutamate ratios. Transl Psychiatry. 2020 Jan 27;10(1):9. doi: 10.1038/s41398-020-0692-2.

  9. Wang K, Xu M, Ji Y, Zhang L, Du X, Li J, Luo Q*, Li F*. Altered social cognition and connectivity of default mode networks in the co-occurrence of autistic spectrum disorder and attention deficit hyperactivity disorder. Australian & New Zealand Journal of Psychiatry, 2019 Aug;53(8):760-771. doi: 10.1177/0004867419836031.

  10. Du XJ, Gao XR, Liu X, Shen LX, Wang K, Fan YJ, Sun Y, Liu HL, Wang LL, Luo XM, Wang JG, Gong ZW, Wang Y, Yu YG*, Li F*. Genetic Diagnostic Evaluation of Trio-based Whole Exome Sequencing among Children with Diagnosed or Suspected Autism Spectrum Disorder. Front. Genet., 2018 Nov 30;9:594.

  11. Fan YJ, Du XJ, Liu X, Wang LL, Li F*, Yu YG*. Rare copy number variations in a Chinese cohort of autism spectrum disorder. Front. Genet. 2018 Dec 18;9:665.

  12. Li WG, Liu M, Deng S, Liu Y, Shang L, Ding J, Hsu T, Jiang Q, Li Y, Li F*, Zhu Michael*, and Xu TL*. ASIC1a regulates insular long-term depression and is required for extinction of conditioned taste aversion. Nature Communication,2016,7: 13770.

  13. Li F, Jin XM, Liu B, Zhuang W, Scalabrin B .Follow-Up Formula Consumption in 3- to 4-Year-Olds and Respiratory Infections: An RCT. Pediatrics, 2014, 133(6):e1533-40.

  14. Li F#, Wu T#, Lei X, Zhang H, Mao M*, Zhang J*. The Apgar score and infant mortality. PLoS One, 2013 Jul 29, 8(7): e69072.  

  15. Li F*, Zhou Y, Li S, Jiang F, Jing X,Zhang Y, Tong S, Shen X*. Environmental risk factor assessment: a multilevel analysis of childhood asthma in China. World Journal of Pediatrics, 2013,9(6): 332-336.

  16. Li F, Zhou Y, Li S, Jiang F, Jing X, Zhang Y, Tong S, Shen X. Prevalence and risk factors of childhood allergic diseases in eight metropolitan cities in China: a multicenter study. BMC Public Health, 2011,11:437

  17. Wang LP, Li F, Wang D, Xie K, Wang D, Shen X, Tsien JZ. NMDA receptors in dopaminergic neurons are crucial for habit learning. Neuron, 2011, 72(6): 1055-66.

  18. Li F, Tsien JZ. Memory and the NMDA receptors. New England Journal of Medicine, 2009, 361(3): 302-303.