LI Shenghui




Research Areas: 妇女儿童睡眠健康

Research experience

Pro. Shenghui Li has been dedicated in sleep related research for more than 10 years. Her research team surveyed sleep habits, sleep problems, and influential factors among Chinese children and adolescents based on large epidemiological study. Moreover, they evaluated the impact of sleep on children and adolescents’ growth and development from perspectives of endocrinology and neurobiology. Currently, Pro. Li attempts to examine the associations between pregnant sleep parameters and several outcome measurements including pregnancy complications, birth outcomes and infant neurobehavioral development status. In addition, Pro. Li and her research team is carrying out a multi-center clinical research to explore the environment - genetic interactions and embryonic development.  

Main achievements

Pro. Shenghui Li is responsible for more than twenty scientific research projects, which including national as well as provincial projects, and receives five talent funds in varies aspects. She has more than 100 academic papers published, 80 of which are published in SCI journals as first author or corresponding author. She also edits two textbooks of People’s Medical Publishing House for undergraduate and postgraduate students majoring in preventive medicine, and edits an academic monograph in the field of sleep “Encyclopeida of Sleep and Dream”. As a co-editor, Shenghui Li complies a sleep science treatise “Focusing on Sleep--From the First 1000 Days of Life”. Her series of studies of sleep won the 1st prize in science and technology of the ministry of education in 2011 and 2nd prize of national science and technology progress in 2012, respectively.

Currently, she is the leader in the field of maternal and child health of the school of public health, Shanghai Jiao Tong University, and is the PI in their research group. She is hired as the professor of the Environmental and Child Health Education Key Laboratory, and the professor of the Shanghai Children’s Medical Center. Based on her productive work, She was rewarded as of excellent discipline leader in field of public health by Shanghai municipal government.


  1. Li R, Chen Y, Zhao A, Huang L, Long Z, Kang W, Yin Y, Tong S, Guo Y, Li S. Exploring Genetic Association of Insomnia with Allergic Disease and Asthma: A Bidirectional Mendelian Randomization Study [J].Respir Res. 2022;23(1):84.

  2. Chen Y#, Zhao A#, Lyu J, Hu Y, Yin Y, Qu J, Tong S, Li S. Association of Delayed Chronotype with Allergic Diseases in Primary School Children [J]. Chronobiol Int, 2022, 1-12.

  3. Long Z,Huang L, Lyu J, Xia Y, Chen Y, Li R, Wang Y, Li S. Trends of central obesity and associations with nutrients intake and daily behaviors among women of childbearing age in China. BMC Women’s Health. 2022 Jan;22(12):1-11.

  4. Hu YB, Chen YT, Liu SJ, Jiang F, Wu MQ, Yan CH, Tan JG, Yu GJ, Hu Y, Yin Y, Qu JJ, Li SH, Tong SL. Increasing prevalence and influencing factors of childhood asthma: a cross-sectional study in Shanghai, China. World J Pediatr. 2021;17(4):419-428.

  5. Hu Y, Chen Y, Liu S, Jiang F, Wu M, Yan C, Tan J, Yu G, Hu Y, Yin Y, Qu J, Li S, Tong S. Breastfeeding duration modified the effects of neonatal and familial risk factors on childhood asthma and allergy: a population-based study.Respir Res. 2021;22(1):41.

  6. Huang L, Long Z, Lyu J, Chen Y, Li R, Wang Y, Li S. The Associations of Trajectory of Sleep Duration and Inflammation with Hypertension: A Longitudinal Study in China. Nat Sci Sleep. 2021;13:1797-1806.

  7. Zhao A, Zhao K, Xia Y, Lyu J, Chen Y, Li S. Melatonin inhibits embryonic rat H9c2 cells growth through induction of apoptosis and cell cycle arrest via PI3K-AKT signaling pathway. Birth Defects Res. 2021 (7):1-11.

  8. Chen Y, Yang Q, Zhao K, Wu Z, Shen X, Li S. Associations of sleep characteristics with atopic disease: a cross-sectional study among Chinese adolescents. Allergy Asthma Clin Immunol. 2021 Feb 22;17(1):21.

  9. Xia Y, Lyu S, Zhang J, Chen Y, Gao L, Zhao A, Wang Y; Li S. Development of fetal growth charts in twins stratified by chorionicity and mode of conception: a retrospective cohort study in China. Chinese Medical Journal, 2021, 134(15): 1819-1827.

  10. Xia Y, Zhong L, Tan J, Zhang Z, Lyu J, Chen Y, Zhao A, Huang L, Long Z, Liu NN, Wang H, Li S. How to Understand "Herd Immunity" in COVID-19 Pandemic. Front Cell Dev Biol. 2020 Sep 24;8:547314.

  11. Chen Y, Zhu J,Lyu J, Xia Y, Zhu J, Tong S, Ying Y, Qu J, Li S. Effect of Maternal Sleep, Physical Activity and Screen Time during Pregnancy on the Risk of Childhood Respiratory Allergies: a Sex-specific Study. Respir Res. 2020 Sep 3;21(1):230.

  12. Chen Y, Zhu J,Lyu J, Xia Y, Ying Y, Hu Y, Qu J, Tong S, Li S. Association of Maternal Prepregnancy Weight and Gestational Weight Gain With Children’s Allergic Diseases. JAMA Netw Open. 2020 Sep; 3(9): e2015643.

  13. Zhao A, Zhao K, Xia Y, Yin Y, Zhu J, Hong H, Li S Periconceptional use of cod liver oil, a vitamin D source, could decrease the risk of congenital heart disease in offspring. Cardiology in the Yong. 28 August 2020

  14. Chen Y, Zhao A, Xia Y, Lyu J, Ye X, Liu N, Li S .In the Big Picture of COVID-19 Pandemic: What Can Sleep Do. Sleep Med. 2020;72:109-110

  15. Lyu J, Ye X, Chen Y, Xia Y, Zhu J, Tong S, Yong Y, Qu J, Li S. Children's Sleep May Depend on Maternal Sleep Duration During Pregnancy: A Retrospective Study.Nat Sci Sleep. 2020;12:197-207.

  16. Lyu J, Zhu Q, Tong S, Su M, Li S, Hua J. Trajectories of sleep quality and associations with excessive gestational weight gain during pregnancy. Sleep and Biological Rhythms. 2020; 18(3), 249-257.    

  17. Hung L, Lyu J, Long Z, Xia Y, Chen Y, Ye X, Li S. Gender-specific longitudinal association of sleep duration with blood pressure among children: evidence from CHNS 2004-2015. Int J Hypertens. 2020;7:1-9.

  18. Xia YQ, Zhao KN, Zhao AD, Zhu JZ, Hong HF, Wang YL, Li SH. Associations of maternal upper respiratory tract infection/influenza during early pregnancy with congenital heart disease in offspring: evidence from a case-control study and meta-analysis. BMC Cardiovasc Disord. 2019 Dec 2;19(1):277 (IF: 2.1)

  19. Lyu J, Zhao K, Xia Y, Zhao A, Yin Y, Hong H, Li S. Associations between maternal social support and stressful life event with ventricular septal defect in offspring: a case-control study. BMC Pregnancy Childbirth. 2019 Nov 21;19(1):429. (IF: 2.4)

  20. Zhao A, Zhao K, Xia Y, Yin Y, Zhu J, Hong H, Li S. Exploring associations of maternal sleep during periconceptional period with congenital heart disease in offspring. Birth Defects Res. 2019 Aug 1;111(13):920-931 (IF: 2.3)

  21. Kena Zhao, Jinwen Zhang, Zengqiang Wu, Xiaoming Shen, Shilu Tong, Shenghui Li. The relationship between insomnia symptoms and school performance among 4966 adolescents in Shanghai, China. Sleep Health. 2019 Jun;5(3):273-279 (IF: 3.1)

  22. Li S, Wang J, Xu Z, Wang X, Xu G, Zhang J, Shen X, Tong S. Exploring associations of maternal exposure to ambient temperature with duration of gestation and birth weight: a prospective study. BMC Pregnancy Childbirth. 2018;18(1):513.  (IF: 2.4)

  23. Zhang J, Xu Z, Zhao K, Chen T, Ye X, Shen Z, Wu Z, Zhang J, Shen X, Li S. Sleep Habits, Sleep Problems, Sleep Hygiene, and Their Associations With Mental Health Problems Among Adolescents.J Am Psychiatr Nurses Assoc. 2018 May/Jun;24(3):223-234.

  24. Zhang JW, Branch W, Hoffman M, De Jong A, Li SH, Troendle J, Zhang J. In which groups of pregnant women can the caesarean delivery rate likely be reduced safely in the USA? A multicentre cross-sectional study. BMJ Open. 2018;8(8):e021670. (IF: 2.3)

  25. Li S, Hua J, Hong H, Wang Y, Zhang J*. Interpregnancy Interval, Maternal Age, and Offspring’s BMI and Blood Pressure at 7 Years of Age. J Hum Hypertens.  2018 May;32(5):349-358.

  26. Li L, Zhao K, Hua J, Li S*. Association between Sleep-disordered Breathing (SDB) during Pregnancy and Maternal and Fetal Outcomes: An Updated Systematic Review and Meta-analysis. Front Neurol. 2018 May 28;9:91.

  27. Zhang J, Xu Z, Zhao K, Chen T, Ye X, Shen Z, Wu Z, Zhang J, Shen X, Li S (李生慧)*. Sleep habits, sleep problems, sleep hygiene, and their associations with mental health problems among adolescents. J Am Psychiatr Nurses Assoc. 2017 Jul 1:1078390317715315.