Center for Single-Cell Omics
Center for Single-Cell Omics

1C4E4

VIJG Jan

Founding Director,Principle Investigator

Email: jvijg@shsmu.edu.cn

Tel: +86(0)21-63846590

Address: Room 501, East 5 building, 227 South Chongqing, Shanghai, China

Educational Background

  • 1980 B.A. State University of Leiden, Leiden, The Netherlands

  • 1982 M.Sc. State University of Leiden, Leiden, The Netherlands

  • 1987 Ph.D. State University of Leiden, Leiden, The Netherlands

Professional Experience

  • 1982-1987   Research Associate, TNO Institute for Experimental Gerontology, Rijswijk, The Netherlands

  • 1987-1990   Head, Department of Molecular Biology, TNO Institute for Experimental Gerontology, Rijswijk, The Netherlands

  • 1990-1996   Lecturer on Medicine, Harvard Medical School, Division on Aging, Boston, Massachusetts

  • 1993-1998   Director, Molecular Genetics Section, Gerontology Division, Department of Medicine, Beth Israel Hospital, Boston, MA.

  • 1996-1998   Associate Professor of Medicine, Harvard Medical School, Boston, Massachusetts

  • 1998-2006   Professor of Physiology, University of Texas Health Science Center at San Antonio

  • 1998-2000   Director of Basic Research, CTRC Institute for Drug Development, San Antonio, Texas

  • 2006-2008   Professor, Buck Institute for Research on Aging, Novato, CA

  • 2008-   Professor and Chairman, Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA.

  • 2013-   Adjunct Professor, Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea.

  • 2019-   Founding Director, Shanghai Jiao Tong University School of Medicine Center for Single-Cell Omics (CSCOmics)

Publications

  1. J. Vijg, From DNA damage to mutations: All roads lead to aging. Ageing Res Rev, 2021. 68: p. 101316.

  2. B. Schumacher, J. Pothof, J. Vijg, and J. H. J. Hoeijmakers, The central role of DNA damage in the ageing process. Nature, 2021. 592(7856): p. 695-703.

  3. M. Olcha, X. Dong, H. Feil, X. Hao, M. Lee, S. Jindal, E. Buyuk, and J. Vijg, A workflow for simultaneous DNA copy number and methylome analysis of inner cell mass and trophectoderm cells from human blastocysts. Fertil Steril, 2021.

  4. X. Dong, S. Sun, L. Zhang, S. Kim, Z. Tu, C. Montagna, A. Y. Maslov, Y. Suh, T. Wang, J. Campisi, and J. Vijg, Age-related telomere attrition causes aberrant gene expression in sub-telomeric regions. Aging Cell, 2021: p. e13357.

  5. Z. D. Zhang, S. Milman, J. R. Lin, S. Wierbowski, H. Yu, N. Barzilai, V. Gorbunova, W. C. Ladiges, L. J. Niedernhofer, Y. Suh, P. D. Robbins, and J. Vijg, Genetics of extreme human longevity to guide drug discovery for healthy ageing. Nat Metab, 2020. 2(8): p. 663-672.

  6. R. R. White, A. Y. Maslov, M. Lee, S. E. Wilner, M. Levy, and J. Vijg, FOXO3a acts to suppress DNA double-strand break-induced mutations. Aging Cell, 2020: p. e13184.

  7. J. Vijg and X. Dong, Pathogenic Mechanisms of Somatic Mutation and Genome Mosaicism in Aging. Cell, 2020. 182(1): p. 12-23.

  8. S. Sun, R. R. White, K. E. Fischer, Z. Zhang, S. N. Austad, and J. Vijg, Inducible aging in Hydra oligactis implicates sexual reproduction, loss of stem cells, and genome maintenance as major pathways. Geroscience, 2020. 42(4): p. 1119-1132.

  9. X. Dong, L. Zhang, X. Hao, T. Wang, and J. Vijg, SCCNV: A Software Tool for Identifying Copy Number Variation From Single-Cell Whole-Genome Sequencing. Front Genet, 2020. 11: p. 505441.

  10. K. Brazhnik, S. Sun, O. Alani, M. Kinkhabwala, A. W. Wolkoff, A. Y. Maslov, X. Dong, and J. Vijg, Single-cell analysis reveals different age-related somatic mutation profiles between stem and differentiated cells in human liver. Sci Adv, 2020. 6(5): p. eaax2659.

  11. L. Zhang, X. Dong, M. Lee, A. Y. Maslov, T. Wang, and J. Vijg, Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan. Proc Natl Acad Sci U S A, 2019. 116(18): p. 9014-9019.

  12. Lei Zhang and Jan Vijg, Somatic Mutagenesis in Mammals and Its Implications for Human Disease and Aging. Annual Review of Genetics, 2018. 52(1): p. 397-419.

  13. A. Seluanov, V. N. Gladyshev, J. Vijg, and V. Gorbunova, Mechanisms of cancer resistance in long-lived mammals. Nat Rev Cancer, 2018. 18(7): p. 433-441.

  14. J. M. Hebert and J. Vijg, Cell Replacement to Reverse Brain Aging: Challenges, Pitfalls, and Opportunities. Trends Neurosci, 2018. 41(5): p. 267-279.

  15. B. Milholland, X. Dong, L. Zhang, X. Hao, Y. Suh, and J. Vijg, Differences between germline and somatic mutation rates in humans and mice. Nat Commun, 2017. 8: p. 15183.

  16. X. Dong, L. Zhang, B. Milholland, M. Lee, A. Y. Maslov, T. Wang, and J. Vijg, Accurate identification of single-nucleotide variants in whole-genome-amplified single cells. Nat Methods, 2017. 14(5): p. 491-493.

  17. W. P. Vermeij, M. E. Dolle, E. Reiling, D. Jaarsma, C. Payan-Gomez, C. R. Bombardieri, H. Wu, A. J. Roks, S. M. Botter, B. C. van der Eerden, S. A. Youssef, R. V. Kuiper, B. Nagarajah, C. T. van Oostrom, R. M. Brandt, S. Barnhoorn, S. Imholz, J. L. Pennings, A. de Bruin, A. Gyenis, J. Pothof, J. Vijg, H. van Steeg, and J. H. Hoeijmakers, Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice. Nature, 2016. 537(7620): p. 427-431.

  18. W. Quispe-Tintaya, T. Gorbacheva, M. Lee, S. Makhortov, V. N. Popov, J. Vijg, and A. Y. Maslov, Quantitative detection of low-abundance somatic structural variants in normal cells by high-throughput sequencing. Nat Methods, 2016. 13(7): p. 584-6.

  19. X. Dong, B. Milholland, and J. Vijg, Evidence for a limit to human lifespan. Nature, 2016. 538(7624): p. 257-259.

  20. R. R. White, B. Milholland, A. de Bruin, S. Curran, R. M. Laberge, H. van Steeg, J. Campisi, A. Y. Maslov, and J. Vijg, Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing. Nat Commun, 2015. 6: p. 6790.

  21. S. Gravina, S. Ganapathi, and J. Vijg, Single-cell, locus-specific bisulfite sequencing (SLBS) for direct detection of epimutations in DNA methylation patterns. Nucleic Acids Res, 2015. 43(14): p. e93.

  22. V. Gorbunova, A. Seluanov, Z. Zhang, V. N. Gladyshev, and J. Vijg, Comparative genetics of longevity and cancer: insights from long-lived rodents. Nat Rev Genet, 2014. 15(8): p. 531-40.

  23. M. Gundry, W. Li, S. B. Maqbool, and J. Vijg, Direct, genome-wide assessment of DNA mutations in single cells. Nucleic Acids Res, 2012. 40(5): p. 2032-40.

  24. P. Kapahi and J. Vijg, Aging--lost in translation? N Engl J Med, 2009. 361(27): p. 2669-70.

  25. J. Vijg, A. Y. Maslov, and Y. Suh, Aging: a sirtuin shake-up? Cell, 2008. 135(5): p. 797-8.

  26. J. Vijg and J. Campisi, Puzzles, promises and a cure for ageing. Nature, 2008. 454(7208): p. 1065-71.

  27. K. Khrapko and J. Vijg, Mitochondrial DNA mutations and aging: a case closed? Nat Genet, 2007. 39(4): p. 445-6.

  28. R. Busuttil, R. Bahar, and J. Vijg, Genome dynamics and transcriptional deregulation in aging. Neuroscience, 2007. 145(4): p. 1341-7.

  29. J. Vijg and Y. Suh, Ageing: chromatin unbound. Nature, 2006. 440(7086): p. 874-5.

  30. L. J. Niedernhofer, G. A. Garinis, A. Raams, A. S. Lalai, A. R. Robinson, E. Appeldoorn, H. Odijk, R. Oostendorp, A. Ahmad, W. van Leeuwen, A. F. Theil, W. Vermeulen, G. T. van der Horst, P. Meinecke, W. J. Kleijer, J. Vijg, N. G. Jaspers, and J. H. Hoeijmakers, A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature, 2006. 444(7122): p. 1038-43.

  31. R. Bahar, C. H. Hartmann, K. A. Rodriguez, A. D. Denny, R. A. Busuttil, M. E. Dolle, R. B. Calder, G. B. Chisholm, B. H. Pollock, C. A. Klein, and J. Vijg, Increased cell-to-cell variation in gene expression in ageing mouse heart. Nature, 2006. 441(7096): p. 1011-4.

  32. J. Vijg and Y. Suh, Genetics of longevity and aging. Annu Rev Med, 2005. 56: p. 193-212.

  33. P. Hasty, J. Campisi, J. Hoeijmakers, H. van Steeg, and J. Vijg, Aging and genome maintenance: lessons from the mouse? Science, 2003. 299(5611): p. 1355-9.

  34. Y. Suh, K. A. Lee, W. H. Kim, B. G. Han, J. Vijg, and S. C. Park, Aging alters the apoptotic response to genotoxic stress. Nat Med, 2002. 8(1): p. 3-4.

  35. E. Nekhaeva, N. D. Bodyak, Y. Kraytsberg, S. B. McGrath, N. J. Van Orsouw, A. Pluzhnikov, J. Y. Wei, J. Vijg, and K. Khrapko, Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues. Proc Natl Acad Sci U S A, 2002. 99(8): p. 5521-6.

  36. P. Hasty and J. Vijg, Aging. Genomic priorities in aging. Science, 2002. 296(5571): p. 1250-1.

  37. M. E. Dolle, W. K. Snyder, D. B. Dunson, and J. Vijg, Mutational fingerprints of aging. Nucleic Acids Res, 2002. 30(2): p. 545-9.

  38. K. Khrapko, N. Bodyak, W. G. Thilly, N. J. van Orsouw, X. Zhang, H. A. Coller, T. T. Perls, M. Upton, J. Vijg, and J. Y. Wei, Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions. Nucleic Acids Res, 1999. 27(11): p. 2434-41.

  39. N. J. van Orsouw, R. K. Dhanda, R. D. Rines, W. M. Smith, I. Sigalas, C. Eng, and J. Vijg, Rapid design of denaturing gradient-based two-dimensional electrophoretic gene mutational scanning tests. Nucleic Acids Res, 1998. 26(10): p. 2398-406.

  40. T. T. Perls, E. Bubrick, C. G. Wager, J. Vijg, and L. Kruglyak, Siblings of centenarians live longer. Lancet, 1998. 351(9115): p. 1560.

  41. C. Eng and J. Vijg, Genetic testing: the problems and the promise. Nat Biotechnol, 1997. 15(5): p. 422-6.

  42. M. E. Dolle, H. Giese, C. L. Hopkins, H. J. Martus, J. M. Hausdorff, and J. Vijg, Rapid accumulation of genome rearrangements in liver but not in brain of old mice. Nat Genet, 1997. 17(4): p. 431-4.

  43. M. E. Boerrigter, M. E. Dolle, H. J. Martus, J. A. Gossen, and J. Vijg, Plasmid-based transgenic mouse model for studying in vivo mutations. Nature, 1995. 377(6550): p. 657-9.

  44. E. Mullaart, G. J. de Vos, G. J. te Meerman, A. G. Uitterlinden, and J. Vijg, Parallel genome analysis by two-dimensional DNA typing. Nature, 1993. 365(6445): p. 469-71.

  45. J. A. Gossen, A. C. Molijn, G. R. Douglas, and J. Vijg, Application of galactose-sensitive E. coli strains as selective hosts for LacZ- plasmids. Nucleic Acids Res, 1992. 20(12): p. 3254.

  46. A. G. Uitterlinden, P. E. Slagboom, D. L. Knook, and J. Vijg, Two-dimensional DNA fingerprinting of human individuals. Proc Natl Acad Sci U S A, 1989. 86(8): p. 2742-6.

  47. J. A. Gossen, W. J. de Leeuw, C. H. Tan, E. C. Zwarthoff, F. Berends, P. H. Lohman, D. L. Knook, and J. Vijg, Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo. Proc Natl Acad Sci U S A, 1989. 86(20): p. 7971-5.

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