Name: Qian Li

Title： Principal Investigator

Email: liqian@shsmu.edu.cn

Tel: +8617717669410

Research Interests

Our lab is interested in how olfactory system, especially the TAAR (Trace Amine-Associated Receptor) subsystem is employed by animals to elicit innate behavioral responses critical for their survival and reproduction. We are also studying molecular mechanisms of singular olfactory receptor gene choice and expression in olfactory sensory neurons. In addition, we are interested in molecular and cellular mechanisms controlling olfactory stem cell differentiation.

Ten Selected Papers

*co-corresponding authors; #co-first authors

1.Fei, Aimei#; Wu, Wanqing#; Tan, Longzhi#; Tang, Cheng#; Xu, Zhengrong; Huo, Xiaona; Bao, Hongqiang; Johnson, Mark; Hartmann, Griffin; Talay, Mustafa; Yang, Cheng; Riegler, Clemens; Joseph, Kristian; Engert, Florian; Xie, X Sunney; Barnea, Gilad; Liberles, Stephen D; Yang, Hui; Li, Qian; “Coordination of two enhancers drives expression of olfactory trace amine-associated receptors”, Nature Communications, 2021, in principle accepted.

2.Gan, Linhua#; Sun, Jingjing#; Yang, Shuo; Zhang, Xiaocui; Chen, Wu; Sun, Yiyu; Wu, Xiaohua; Cheng, Cheng; Yuan, Jing; Li, Anan; Corbett, Mark A.; Dixon, Mathew P.; Thomas, Tim; Voss, Anne K.; Gecz, Jozef; Wang, Guang-Zhong; Bonni, Azad; Li, Qian*; Huang, Ju*; “Chromatin-binding protein PHF6 regulates activity-dependent transcriptional networks to promote hunger response”, Cell Reports, 2020, 30(11): 3717-3728.e6.

3.Tan, Longzhi#; Li, Qian#; Xie, X Sunney; “Olfactory sensory neurons transiently express multiple olfactory receptors during development”, Molecular Systems Biology, 2015, 11(12): 844.

4.Li, Qian; Tachie, Baffour Yaw; Liu, Zhikai; Baldwin, Maude W; Kruse, Andrew C; Liberles, Stephen D; “Non-classical amine recognition evolved in a large clade of olfactory receptors”, eLife, 2015, 4: e10441.

5.Li, Qian; Liberles, Stephen D; “Aversion and attraction through olfaction”, Current Biology, 2015, 25(3): 120-129.

6.Li, Qian; Korzan, Wayne J; Ferrero, David M; Chang, Rui B; Roy, Dheeraj S; Buchi, Melanie; Lemon, Jamie K; Kaur, Angeldeep W; Stowers, Lisa; Fendt, Markus; Liberles, Stephen D; “Synchronous evolution of an odor biosynthesis pathway and behavioral response”, Current Biology, 2013, 23(1): 11-20.