为进一步促进上海市胸科医院的基础实验教学、基础研究以及社会医学服务，2014年6月成立中心实验室。中心实验室正在集中力量打造成胸部肿瘤重点实验室。目前本中心有工作人员11名，其中博士学历3名、研究生学历6名、本科学历2名。中心实验室将建设一支热爱科学研究、熟悉实验技术的基础与临床实验教学相结合的研究和技术人员队伍，从而为全院的基础科学研究提供全面支撑和保障。
中心实验室为本院各临床科室研究生和其他各级研究人员提供研究平台，并将结合临床需要以及国际研究合作开展具有特色疾病的攻关研究，目前承担着国家“十一五”、国家自然科学基金、上海市“登山计划”等多项重大课题的研究。
中心实验室配有细胞培养与代谢平台、生物细胞影像平台、循环肿瘤细胞与流式检测平台、肿瘤免疫与生物治疗平台、药物筛选与动物模型平台、蛋白质组学与信号转导平台、研究用分子病理平台、基因扩增与测序平台。拥有荧光定量 PCR 仪、核酸以及蛋白凝胶成像系统、切片机、核酸蛋白定量测定仪、免疫酶标仪、纯水系统、微量天平、梯度PCR 仪、双向电泳、电穿孔仪、流式细胞仪、各类低温高速离心机、多功能图像分析仪、激光共聚焦显微镜等先进实验设备和多种精密器材，可开展分子生物学、细胞生物学、肿瘤蛋白组学、药物筛选以及免疫生物学等多方面的研究。
中心实验室现已支持开展90项医院课题研究，包括抗体靶向治疗研究、食管癌免疫微环境研究、心脏瓣膜钙化分子机制研究、放化疗对胸部肿瘤精准治疗机制研究等。
Research Center
The research center of Shanghai Chest Hospital was established in June 2014, designed for basic experiment teaching, hospital-based research and social medical service. The center will focus on building a key laboratory for thoracic neoplasms. At present, it has 11 employees including three doctors, six masters and two graduates. The center will build a team with scientific research enthusiasm and professional techniques, providing hospital-based scientific research by combining clinical disease and basic science.
The center provides research platforms for students as well as scientists of clinical departments in the hospital. The future of the research center would be based on international research cooperation in distinctive of clinical diseases. The center is undertaking lots of core projects, including “Key Projects in the National Science & Technology Pillar Program during the Eleventh Five-Year Plan Period,” “National Natural Science Foundation of China,” “Shanghai Climbing Plan” and etc.
Moreover, the center features eight sub-platforms which are cell culture and metabolism platform, biological cell imaging platform, circulating tumor cells and flow detection platform, tumor immuno-biological cancer therapy platform, drug screening and animal model platform, proteomics and signal transduction platform, molecular pathology platform for research and gene amplification and sequencing platform. These platforms are equipped with real-time fluorescence quantitative PCR, nucleic acid and protein gel imaging system, microtome, nucleic acid protein quantitative analyzer, microplate reader, pure water system, micro-balance, gradient PCR instrument, two-dimensional electrophoresis, electroporation, flow cytometry, various kinds of low-temperature high-speed centrifuges, multi-function image analyzers, laser confocal microscopes, and other advanced experimental and precision equipments. These devices can be used to do research in the field of molecular biology, cell biology, tumor proteomics, drug screening, immunobiology and etc.
So far, the center has been supported to conduct 90 hospital research projects, including antibody-targeted therapy research, esophageal cancer immuno-microenvironment research, molecular mechanism of heart valve calcification, and radiotherapy and chemotherapy on the precise mechanism of chest tumors.
