师资队伍
曾凡一
  作者:  2018-12-31

基本信息 >>>

                

曾凡一

发育生物学研究组

电话:63846590-776667

邮箱:fzeng@vip.163.com

研究方向>>>

医学遗传学和发育生物学,尤其是干细胞和哺乳动物胚胎工程等交叉领域的研究  

个人简历 >>>

 曾凡一,美国宾夕法尼亚大学医学/理学双博士,研究员,博导。现任上海交通大学医学院基础医学院,组织胚胎学与遗传发育学系PI,上海交通大学特聘教授、医学院特聘教授。

曾凡一研究员主要从事医学遗传学和发育生物学,尤其是干细胞和哺乳动物胚胎工程等交叉领域的研究,在国际著名期刊《Nature》、《PNAS》等杂志发表SCI论文90 余篇,研究成果多次入选中国基础研究十大新闻以及中国十大科技进展新闻。近年来获得国家自然科学奖二等奖、教育部自然科学奖一等奖、首届第三世界女青年科学家奖、谈家桢生命科学奖创新奖等奖项。担任国际干细胞组织(ISCF)秘书长及伦理委员会中国代表、中国遗传学会第十届理事会常务理事以及人类与医学遗传专业委员会主任委员等职务。

科研项目 >>>

1.          2019YFA0801402    国家重点研发计划子课题胚层形成过程细胞分子调控机制”2019-12~2024-11    383.5    课题负责人

2.          31871484 克隆牛重编程的表观遗传机理研究 国家自然科学基金(面上项目)   2019-01~2022-12  59万元  课题负责人

3.          17-163-12-ZT-005-051-01 新发病原体感染胚胎嵌合体修饰技术 国防科技创新特区课题   2017-07~2020-06  346万元  课题负责人

4.          2016YFC1000503 出生缺陷表观遗传异常模式及防控靶点 国家重点研发计划生殖健康及重大出生缺陷防控研究重点专项   2016-07~2021-07  150万元  课题参与人

论文与专著 >>>

1.          Shuo Tan, Yuan Chen, Yue Gao, Jiaping He, Xinbing Guo, Simin   Zhang, Jingzhi Zhang*, Fanyi Zeng*. β-Galactosidase gene codon   optimization results in post-transcriptional enhancement of expression. Gene,   748: 144676, 2020

2.          Yudan Fang1, Yan Cheng1, Dan Lu1, Xiuli Gong, Guanheng Yang,   Zhijuan Gong, Yiwen Zhu, Xiao Sang, Shuyue Fan, Jingzhi Zhang, Fanyi Zeng.   Treatment of β654-thalassaemia by TALENs in a mouse model. Cell   Proliferation, 51(6): e12491, 2018

3.          Zhijuan Gong1, Qingwen Ma1, Xujun Wang1, Qin Cai, Xiuli Gong,   Georgi Z. Genchev, Hui Lu* and Fanyi Zeng*. A Herpes Simplex Virus   Thymidine Kinase-Induced Mouse Model of Hepatocellular Carcinoma Associated   with Up-Regulated Immune-Inflammatory-Related Signals. Genes, 9(8): 380, 2018

4.          Jingzhi   Zhang, Jingbin Yan, Fanyi Zeng. Recent Progress on Genetic Diagnosis   and Therapy for β-Thalassemia in China and Around the World. Human   Gene Therapy, 29(2): 197-203, 2018.2

5.          Chuanliang Guo1, Yan Xue1, Guanheng Yang, Shang Yin, Wansheng   Shi, Yan Cheng, Xiaoshuang Yan, Shuyue Fan, Huijun Zhang and Fanyi Zeng.   Nanog RNA-binding proteins YBX1 and ILF3 affect pluripotency of embryonic   stem cells. Cell Biology International, 40(8): 847-860, 2016

6.          Xiaoshuang Yan, Yan Xue, Yiye Zhou, Yan Cheng, Shang Yin,   Qingwen Ma, Fanyi Zeng. Activation of proHGF by St14 induces mouse   embryonic stem cell differentiation. Protein&Cell, 7(8): 601-605, 2016

7.          Jingbin Yan, Rong Zhang, Can Xiong, Cheng Hu, Yao Lv, Congrong   Wang, Weiping Jia, Fanyi Zeng. Pyrosequencing Is an Accurate and   Reliable Method for the analysis of Heteroplasmy of the A3243G Mutation in   patients with Mitochondrial diabetes. The Journal of Molecular Diagnostics,   16(4): 431-439, 2014

8.          Rosario Isasi*, Peter W. Andrews, Jay M. Baltz, Annelien L.   Bredenoord, Paul Burton, Ing-Ming Chiu, Sara Chandros Hull, Ji-Won Jung,   Andreas Kurtz, Geoffrey Lomax, Tenneille Ludwig, Michael McDonald, Clive   Morris, Huck Hui Ng, Heather Rooke, Alka Sharma, Glyn N. Stacey, Clare   Williams, Fanyi Zeng, and Bartha Maria Knoppers. Identifiability and   Privacy in Pluripotent Stem Cell Research. Cell Stem Cell, 14(4): 427-430,   2014

9.          Guanheng Yang, Wansheng Shi, Xingyin Hu, Jingzhi Zhang, Zhijuan   Gong, Xinbing Guo, Zhaorui Ren, and Fanyi Zeng. Therapeutic effects of   induced pluripotent stem cells in chimeric mice with β-thalassemia.   Haematologica, 99(8): 1304-1311, 2014

10.      Fanyi Zeng*, Shu-Zhen Huang,   Zhi-Juan Gong, Mei-Jue Chen, Don A Baldwin, Wei Hu, Hui Qian, Jing-bin Yan,   Juan Wang,Yan Ping Xiao, Yves Chalandon, Ashley Ringrose, Zhao-Rui Ren, Allen   Eaves, Connie Eaves, Xiaoyan Jiang*. Long-term deregulated human   hematopoiesis in goats transplanted in utero with BCR-ABL-transduced   lin–CD34+ cord blood cells. Cell Research, 23(6): 859-862, 2013

11.      Z.-J. Gong, Y.-Y. Zhou, M. Xu, Q. Cai, H. Li, J.-B. Yan, J.   Wang, H.-J. Zhang, S.-Y. Fan, Q. Yuan, S.-Z. Huang*, F. Zeng*.   Aberrant expression of imprinted genes and their regulatory network in cloned   cattle. Theriogenology, 78(4): 858-866, 2012

12.      Linlin Wang, Yan Xue, Yihang Shen, Wei Li1, Yan Cheng,   Xiaoshuang Yan, Wansheng Shi, Juan Wang, Zhijuan Gong, Guanheng Yang,   Chuanliang Guo, Yiye Zhou, Xiang Wang, Qi Zhou, Fanyi Zeng. Claudin 6:   a novel surface marker for characterizing mouse pluripotent stem cells. Cell   Research, 22(6): 1082-1085, 2012

13.      Mai X. Luong*, Jonathan Auerbach, Jeremy M. Crook, Laurence   Daheron, Derek Hei, Geoffrey Lomax, Jeanne F. Loring, Tenneille Ludwig,   Thorsten M. Schlaeger, Kelly P. Smith, Glyn Stacey, Ren-He Xu, and Fanyi   Zeng. A Call for Standardized Naming and Reporting of Human ESC and iPSC   Lines. Cell Stem Cell, 8(4): 357-359, 2011

14.      Zhong-hai Yan, Yi-ye Zhou, Jing Fu, Fei Jiao, Lei-wen Zhao,   Peng-fei Guan, Shu-zhen Huang, Yi-tao Zeng, Fanyi Zeng. Donor-host   mitochondrial compatibility improves efficiency of bovine somatic cell   nuclear transfer. BMC Developmental Biology, 10: 31, 2010

15.      Xiao-yang Zhao, Wei Li, Zhuo Lv, Lei Liu, Man Tong, Tang Hai,   Jie Hao, Chang-long Guo, Qing-wen Ma, Liu Wang, Fanyi Zeng*, Qi Zhou*.   iPS cells produce viable mice through tetraploid complementation. Nature,   461(7260): 86-90, 2009