研究组长介绍

吴学锋

电话：63846590-776684

邮箱：xuefengwu@shsmu.edu.cn

个人简历      

1995-2002  南开大学学士(1999)/硕士(2002) 

2002-2003  上海荣盛生物技术有限公司技术中心 

2003-2008  美国宾夕法尼亚州州立大学(The Pennsylvania State University) 博士

2008-2009  M. D. Anderson Cancer Center 博士后

2010-2014  美国加州大学圣地亚哥分校(UCSD) 博士后/助理项目科学家

2014-2016  Ionis (former Isis) Pharmaceuticals Senior Scientist

2016.03-至今 上海交通大学医学院上海市免疫学研究所 研究员

研究方向

炎症在肿瘤发生发展和转移等多个步骤中都起着至关重要的作用。本实验室集中研究连接炎症和肿瘤的细胞和分子机制。从以下三个方面开展研究：1.阐述肿瘤细胞来源的信号如何调控其微环境中的免疫细胞和免疫反应；2.树突状细胞和调节性T细胞抗肿瘤免疫的机制；3.探讨调控肿瘤转移的免疫调控机制。我们长期的目标是开发治疗免疫疾病和癌症的药物和新策略。

科研项目

1. 31670910，国家自然科学基金面上项目，泛素缀合酶Ubc13在树突状细胞中的免疫调控功能及机制研究，2017/1-2020/12，项目负责人；

2. 海外高层次人才青年项目，2017/9-2022/12，项目负责人。

3.国家重点研发计划干细胞及转化研究重点专项，项目编号：2020YFA0112900, 2020.10-2024.12，骨干。

论文与专著

1.Yang XD, Li W, Zhang S, Wu D, Jiang X, Tan R, Niu X, Wang Q, Wu X, Liu Z, Chen LF, Qin J, Su B. PLK4 deubiquitination by Spata2-CYLD suppresses NEK7-mediated NLRP3 inflammasome activation at the centrosome. EMBO J. 2020 Jan 15;39 (2):e102201. PMID:31762063

2. Wang T, Cao Y, Zheng Q, Tu J, Zhou W, He J, Zhong J, Chen Y, Wang J, Cai R, Zuo Y, Wei B, Fan Q, Yang J, Wu Y, Yi J, Li D, Liu M, Wang C, Zhou A, Li Y, Wu X, Yang W, Chin YE, Chen G, Cheng J. SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism. Mol Cell. 2019 Aug 22;75(4):823-834.e5. PMID: 31302001

3. Huang X, Zuo Y, Wang X, Wu X, Tan H, Fan Q, Dong B, Xue W, Chen GQ, Cheng J. SUMO-Specific Protease 1 Is Critical for Myeloid-Derived Suppressor Cell Development and Function. Cancer Res. 2019 Aug 1;79(15):3891-3902. PMID: 31186231

4. Yu X, Lao Y, Teng XL, Li  S, Zhou Y, Wang F, Guo X, Deng S, Chang Y, Wu X, Liu Z, Chen L, Lu LM, Cheng J, Li B, Su B, Jiang J, Li HB, Huang C, Yi J, Zou Q. SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation. Nat Commun. 9(1):3157. (2018) PMID: 30089837

5. Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle NK, Dhar D, Banerjee S, Fagman JB, Browne CD, Umemura A, Valasek MA, Kessler H, Tarin D, Goggins M, Reya T, Diaz- Meco M, Moscat J, Karin M. Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. Cancer Cell. 32(6):824-839.e8. (2017) PMID: 29153842

6.Kaneda MM, Messer KS, Ralainirina N, Li H, Leem C, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA. .PI3Kγ is a molecular switch that controls immune suppression
.Nature,2016,539(7629):437-442. 

7. Wu X, M Karin. Emerging roles of Lys63-linked polyubiquitylation in immune responses.Immunol Rev. ,2015,266(1):161-74. 

8.  Wu X, W Zhang, J Font-Burgada, T Palmer, AS Hamil, SK Biswas, M Poidinger, N Borcherding, Q Xie, LG Ellies, N Lytle, LW Wu, J Yang, SF Dowdy, T Reya, M Karin.Ubiqutin-conjugating Enzyme Ubc13 Controls Breast Cancer Metastasis through a TAK1-p38 MAP Kinase Cascade.PNAS,2014,111(38): 13870-5. 

9.  Wu X^#, Zhang M^#and Sun S-C.Mutual regulation between deubiquitinase CYLD and Retroviral Oncoprotein Tax .Cell & Bioscience,2011,1(1):27. 

10.  Hu H^#, Wu X^#, Jin W, Chang M, Cheng X and Sun S-C.Noncanonical NF-κB regulates inducible costimulator (ICOS) ligand expression and T follicular helper cell development .PNAS,2011,108(31):12827-32. 

11.  Wu X, M Yamamoto, S Akira, and S-C Sun.Regulation of hematopoiesis by the K63-specific ubiquitin-conjugating enzyme Ubc13 .PNAS,2009,106 (49): 20836-41.  

12.  Lee A^#, Wu X^#, H Cheng, X Zhou, X Cheng, and S-C Sun.CARMA1 regulation of Treg development involves modulation of IL-2 receptor signaling .J. Biol Chem. ,2010,285(21): 15696-703. 

13.  Zhang M^#, Wu X^#, AJ Lee, W Jin, M Chang, A Wright, T Imaizumi, and S-C Sun.Regulation of IKK-related kinases and antiviral responses by tumor suppressor CYLD . J Biol Chem.,2008,283(27): 8621-6. 

14.  Wu X, S-C Sun.Retroviral oncoprotein Tax deregulates NF-κB by activating Tak1 and mediating Tak1-IKK physical association .EMBO Rep.,2007,8(5): 510-5. 

15.  Inokuchi-Shimizu S, EJ Park, YS Roh, L Yang, B Zhang, J Song, S Liang, M Pimienta, K Taniguchi, X Wu, K Asahina, W Lagakos, MR Mackey, S Akira, MH Ellisman, DD Sears, JM Olefsky, M Karin, DA Brenner, E Seki.TAK1-Mediated Autophagy and Fatty Acid Oxidation Prevent Hepatosteatosis and Tumorigenesis .J Clin Invest.,2014,124(8):3566-78. 

16.  Charlaftis N, Suddason T, X Wu, M Karin and E Gallagher.The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines .EMBO J.,2014,33(21):2581-96. 

17.  Zhang H, H Hu, N Greeley, J Jin, A Matthews, E Ohashi, M Caetano, H Li, X Wu, P Mandel, J McMurray, SJ Moghaddam, S-C Sun, S. Watowich.STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13 .Nature Communications,2014,5:5798. 

18.  Zhang W, Tan W, Wu X, Poustovoitov M, Strasner A, Li W, Borcherding N, Ghassemian M, Karin M.A NIK-IKKα Module Expands ErbB2-Induced Tumor-Initiating Cells by Stimulating Nuclear Export of p27/Kip1 .Cancer Cell,2013,23(5):647-59. 

19.  Li N, Wu X, Holzer RG, Lee JH, Todoric J, Park EJ, Ogata H, Gukovskaya AS, Gukovsky I, Pizzo DP, Vandenberg S, Tarin D, Atay C, Arkan MC, Deerinck TJ, Moscat J, Diaz-Meco M, Dawson D, Erkan M, Kleeff J, Karin M.Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice .J Clin Invest.,2013,123(5):2231-43.  

20.  Mancino A, Habbeddine M, Johnson E, Luron L, Bebien M, Memet S, Fong C, Bajenoff M, Wu X, Karin M, Caamano J, Chi H, Seed M, Lawrence T.I kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection .EMBO J.,2013,32(6):816-28. 

21.  Chang JH, Xiao Y, Hu H, Jin J, Yu J, Zhou X, Wu X, Johnson HM, Akira S, Pasparakis M, Cheng X, Sun SC.Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion effector-like T cells .Nat Immunol.,2012,13: 481-490. 

22.  Zhang M, Lee AJ, Wu X, Sun SC.Regulation of antiviral innate immunity by deubiquitinase CYLD .Cell Mol Immunol.,2011,8(6):502-4. 

23.  Xu G, Y-C Lo, Q Li, G Napolitano, Wu X, X Jiang, Karin M and Wu H.Crystal structure of the inhibitor of κB kinase β (IKKβ).Nature,2011,472 (7343):325-30. 

24.  Reiley WW, Jin W, Lee AJ, Wright A, Wu X, Tewalt EF, Leonard TO, Norbury CC, Fitzpatrick L, Zhang M, Sun SC.Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses .J Exp Med.,2007,204(6): 1475-85. 

25.  Jin W, Reiley WW, Lee AJ, Wright A, Wu X, Zhang M, Sun SC.Deubiquitinating enzyme CYLD regulates the peripheral development and naive phenotype maintenance of B cells .J Biol Chem.,2007,282(21): 15884-93. 

26.  Babu G, Waterfield M, Chang M, Wu X, Sun SC.Deregulated activation of oncoprotein kinase Tpl2/Cot in HTLV-I-transformed T cells.J Biol Chem.,2006,281(20): 14041-7. 

27.  Babu GR, Jin W, Norman L, Waterfield M, Chang M, Wu X, Zhang M, Sun S.Phosphorylation of NF-kappaB1/p105 by oncoprotein kinase Tpl2: implications for a novel mechanism of Tpl2 regulation .Biochim Biophys Acta.,2006,1763(2): 174-81. 

28.  Reiley W, M Zhang, Wu X, E Granger, and S-C Sun.Regulation of the deubiquitinating enzyme CYLD by IKKγ-dependent phosphorylation .Mol. Cell. Biol.,2005,25(10): 3886-95. 

荣誉与奖励

海外高层次人才青年项目

团队介绍

吴学锋课题组现有助理研究员1名，实验技术员1名，在读博士研究生生3名，在读硕士研究生1名。