研究组长介绍 >>>
李兵, 博士导师，学术带头人，上海市海外高层次人才专家。1994年本科毕业于中国农业大学生物学院，1997年获北京大学硕士学位，2002年获宾夕法尼亚州立大学生物化学博士学位，随后在美国斯托瓦斯医学研究所Dr. Jerry Workman实验室从事博士后研究。2008年任美国德克萨斯大学西南医学中心助理教授, WA "Tex" Moncrief讲席学者。2017年加入上海交通大学医学院基础医学院，任生物化学与细胞分子生物学系主任。课题组长期致力于染色质生物学和基因表达调控的基础研究，近年来开始开展癌症表观遗传学的基础及转化型研究。突出的科学贡献主要包括首次发现组蛋白H3K36甲基化调控途径并阐明其分子调控机理，组蛋白变种及染色质重塑复合物结构与功能的研究。在Science，Nature，Cell，Genes & Development，Molecular Cell 和Nature Structure & Molecular Biology 等发表50余篇论文，被引用超过10，000次。曾获得美国March of Dimes基金会Basil O’Connor Scholar Research Award，宾州州立大学保罗伯格分子生物学奖，Braucher scholarship和 Braddock Graduate Fellowship等荣誉。长期作为Cell，Molecular Cell，Genes & Development，Nature Chemical Biology, Nature Communication，NAR和PNAS 等杂志的审稿人，并应邀在国际大会和学术讲座上发言70余次。迄今已获得了国家自然科学基金重点项目、面上项目和科技部国家重点研发计划的支持。作为课程负责人获得2018年“上海高校示范性全英语教学课程建设”项目立项，2019年上海交通大学博士生致远荣誉计划立项建设课程。
研究方向与进展 >>>
1. 癌症表观遗传学及新一代表观抗癌小分子药物开发
2. 染色质重塑复合物调控癌症发生发展的分子机理及其在肌肉发育再生过程中的功能与调控
3. RNA聚合酶II CTD 协调转录区染色质调控的分子机制
4. 相变诱发融合转录因子的致癌机理及对染色体三维结构的调控
5. 获得性性状遗传相关重要分子的作用机制
6. 干细胞谱系分化的表观遗传机制
7. 组蛋白核运输及DNA复制关联的染色质组装的调控机理
科研项目 >>>
1.国家自然科学基金面上项目，31872817，RNA聚合酶II CTD相互作用组功能调控的分子机理，2019.01-2022.12，在研，主持。
2.国家重点研发计划“生殖健康及重大出生缺陷防控研究”重点专项-子课题，2018YFC1004504，获得性性状遗传相关重要分子的作用，2018年12月-2021年12月，在研，主持（子课题负责人）。
3.国家自然科学基金重点项目，32030019，共转录表观遗传复合物在移动中聚合酶上功能调节的机制研究，2021.01-2025.12，在研，主持。
代表性论文、专著与专利 >>> (选自49篇，引用次数>10,000)
49. Dian-Jia Liu, Fan Zhang, Yi Chen, Yi Jin, Yuan-Liang Zhang, Shu-Bei Chen, Yin-Yin Xie, Qiu-Hua Huang, Wei-Li Zhao, Lan Wang, Peng-Fei Xu, Zhu Chen, Sai-Juan Chen, Bing Li, Aijun Zhang, Xiao-Jian Sun (2020) setd2 knockout zebrafish is viable and fertile: differential and developmental-stress-related requirements for Setd2 and histone H3K36 trimethylation in different vertebrate animals Cell Discovery 6(1): 72
48. Xu Zhu*, Bingxue Lan*, Xianfu Yi*, Chaoran He, Lin Dang, Xingquan Zhou, Yumei Lu, Yongzhan Sun, Zhiheng Liu, Xue Bai, Kai Zhang,Bing Li, Mulin Jun Li, Yupeng Chen, Lirong Zhang (2020) HRP2-DPF3a-BAF complex coordinates histone modification and chromatin remodeling to regulate myogenic gene transcription Nucleic Acids Research48(12):6563-6582
47. Julia V. DiFiore, Travis S. Ptacek, Yi Wang,Bing Li, Jeremy Simon and Brian D. Strahl (2020) Unique and Shared Roles for Histone H3K36 Methylation States in Transcription Regulation FunctionsCell Reports31(10):107751
46. Yanhua Du, Jun Lin, Rulin Zhang, Wanli Yang, Heng Quan, Lijuan Zang, Yaqin Han,Bing Li*, Hong Sun and Jun Wu (2019) Ubiquitin Specific Peptidase 5 Promotes Ovarian Cancer Cell Proliferation Through Deubiquitinating HDAC2Aging11(21):9778-9793
45. Wei Wang, Jun Xu, Oliver Limbo, Jia Fei, George A. Kassavetis, Jenny Chong, James T. Kadonaga, Paul Russell,Bing Li*and Dong Wang (2019) Molecular basis of chromatin remodeling by Rhp26, a yeast CSB orthologProc Natl Acad Sci USA. 116(13):6120-6129(*co-correspondence)
44. Jun Wu, Yimin Lao andBing Li(2019) Nuclear actin switch of the INO80 remodelerJ Mol Cell Biol.2019 May 1;11(5):343-344
43. Buki Kwon, Palinda Ruvan Munashingha, Yong-Keol Shin, Chul-Hwan Lee,Bing Liand Yeon-Soo Seo (2016) Physical and functional interactions between nucleosomes and Rad27, a critical component of DNA processing during DNA metabolismThe FEBS Journal283(23):4247-4262
42. Stephen McDaniel, Jennifer Fligor, Chun Ruan, Haochen Cui, Joseph Bridgers, Julia DiFiorea, Angela Gud,Bing Li, and Brian Strahl (2016) Combinatorial histone readout by the dual PHD domains of Rco1 mediates Rpd3S chromatin recruitment and the maintenance of transcriptional fidelityJ. Biol. Chem.291(28):14796-802
41.Andria Schibler, Evangelia Koutelou, Junya Tomida, Marenda Wilson-Pham, Li Wang, Yue Lu, Alexa Parra Cabrera, Renee J. Chosed, Wenqian Li,Bing Li, Xiaobing Shi, Richard D. Wood, and Sharon Y.R. Dent (2016) Histone H3K4 methylation regulates deactivation of the Spindle Assembly Checkpointthrough direct binding of Mad2Genes& Development30(10):1187-97
40. Chun Ruan, Haochen Cui, Chul-Hwan Lee, Sheng Li andBing Li(2016) Homodimeric PHD-domain containing Rco1 constitutes a critical interaction hub within the Rpd3S histone deacetylase complexJ. Biol. Chem.291(10):5428-38
39. Joshua Mayfield, Shuang Fan, Shuo Wei, Mengmeng Zhang,Bing Li, Andrew Ellington, Felicia Etzkorn, and Yan Jessie Zhang (2015) Chemical Tools To Decipher Regulation of Phosphatases by Proline Isomerization on Eukaryotic RNA Polymerase II ACS Chem Biol.2015 Sep 15. [Epub ahead of print]
38.Yi Wang, Yanling Niu andBing Li(2015) Balancing acts of SRI and an auto-inhibitory domain specify Set2 function at transcribed chromatinNucleic Acids Research43(10):4881-92. PMCID: PMC4446442
37. Chun Ruan, Chul-Hwan Lee, Haochen Cui, Sheng Li andBing Li(2015) Nucleosome contact triggers conformational changes of Rpd3S driving high affinity H3K36me nucleosome engagementCell Reports10(2): 204-215
36. Chun Ruan andBing Li(2014) Reading Histone Modifications Fundamentals of Chromatin,edited by J.L. Workman and S.M. Abmayr
35. Daniel S. Ginsburg, Timi Elvuchio Anlembom, Jianing Wang, Sanket R. Patel,Bing Li, and Alan G. Hinnebusch (2014) NuA4 links methylation of histone H3 lysines 4 and 36 to acetylation of histones H4 and H3J. Biol. Chem.289(47):32656-70 PMCID: PMC4239618
34. Hong Wen, Yuanyuan Li, Yuanxin Xi, Shiming Jiang, Sabrina Stratton, Danni Peng, Kaori Tanaka, Yongfeng Ren, Zheng Xia, Jun Wu,Bing Li, Michelle Barton, Wei Li, Haitao Li and Xiaobing Shi (2014) ZMYND11 links histone H3.3 K36 trimethylation to transcription elongation and tumor suppressionNature508(7495):263-8 PMCID: PMC4142212
33. Chul-Hwan Lee, Jun Wu andBing Li(2013) Chromatin remodelers fine-tune H3K36me-directed deacetylation of neighbor nucleosomes by Rpd3S.Molecular Cell52(2):255-63
32. Miyong Yun, Chun Ruan, Jae-Wan Huh andBing Li(2012) Reconstitution of modified chromatin templates for in vitro functional assays.Methods Mol Biol.833:237-53.
31. Jae-Wan Huh, Jun Wu, Chul-Hwan Lee, Miyong Yun, Daniel Gilada, Chad A. Brautigam andBing Li(2012) Multivalent di-nucleosome recognition enables the Rpd3S histone deacetylase complex to tolerate decreased H3K36 methylation levels.EMBO J.31(17):3564-74
30. Xiao-Fen Chen, Benjamin Kuryan, Tasuku Kitada, Nancy Tran, Jing-Yu Li, Siavash Kurdistani, Michael Grunstein,Bing Liand Michael Carey (2011) The Rpd3 Core Complex Is a Chromatin Stabilization ModuleCurr Biol.22(1):56-63
29. Yuwen Ke, Jae-Wan Huh, Ross Warrington, Bing Li, Nan Wu, Mei Leng, Junmei Zhang, Haydn L Ball,Bing Liand Hongtao Yu (2011) PICH and BLM limit histone association with anaphase centromeric DNA threads and promote their resolution.EMBO J30(16):3309-21
28. Miyong Yun, Jun Wu, Jerry Workman andBing Li(2011) Readers of histone modifications. Cell Research21:564–578
27. Ling Cai, Benjamin Sutter,Bing Liand Benjamin P. Tu (2011) Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth Genes. Molecular Cell 42,426-437
26. Chhabi Govind, Hongfang Qiu, Daniel Ginsburg, Chun Ruan, Kimberly Hofmeyer, Cuihua Hu, Venkatesh Swaminathan, Jerry Workman,Bing Liand Alan G. Hinnebusch (2010) Phosphorylated Pol II CTD recruits multiple HDACs, including Rpd3C(S), for methylation-dependent deacetylation of ORF nucleosomesMolecular Cell39, 234-246
25. Mihaela Sardiu, Joshua Gilmore, Michael Carrozza,Bing Li, Jerry Workman, Laurence Florens, Michael Washburn (2009) Determining Protein Complex Connectivity Using a Probabilistic Deletion Network Derived from Quantitative Proteomics.PLoS One4(10):e7310
24. Raymond Camahort, Manjunatha Shivaraju, Mark Mattingly,Bing Li,Shima Nakanishi, Dongxiao Zhu, Ali Shilatifard, Jerry L. Workman and Jennifer L. Gerton (2009) Cse4 is Part of an Octameric Nucleosome in Budding Yeast.Molecular Cell35(6):794-805
23.Bing Li, Jessica Jackson, Matthew D. Simon, Brian Fleharty, Madelaine Gogol, Chris Seidel, Jerry L. Workman and Ali Shilatifard (2009) Histone H3 lysine 36 di-methylation (H3K36me2) is sufficient to recruit the Rpd3S histone deacetylase complex and to repress spurious transcription.J. Biol. Chem.284(12):7970-6
22. Chia-Hui Lin,Bing Li, Selene Swanson, Ying Zhang, Laurence Florens, Michael P. Washburn, Susan M. Abmayr and Jerry L. Workman (2008) Heterochromatin Protein 1a stimulates histone H3 lysine 36 demethylation by the Drosophila KDM4A demethylase.Molecular Cell32(5):696-706
21. Tuba Sural, Shouyong Peng,Bing Li, Jerry L. Workman, Peter J. Park, Mitzi I. Kuroda (2008) The MSL3 chromodomain directs a key targeting step for dosage compensation of the Drosophila X chromosomeNature Structural & Molecular Biology(12):1318-25
20. Tamaki Suganuma, Jose L.Gutierrez,Bing Li, Laurence Florens, Selene K. Swanson, Michael P. Washburn, Susan M. Abmayr and Jerry L. Workman (2008) ATAC is a Double Histone Acetyltransferase Complex that Stimulates Nucleosome SlidingNature Structural & Molecular Biology15(4):364-72
19. Erica Larschan, Artyom A. Alekseyenko, Andrey A. Gortchakov, Shouyong Peng,Bing Li,Pok Yang, Jerry L. Workman, Peter J. Park, and Mitzi I. Kuroda(2007)MSL Complex Is Attracted to Genes Marked by H3K36 Trimethylation Using a Sequence-Independent MechanismMolecular Cell28(1): 121-133
18.Bing Li, Michael Carey and Jerry Workman (2007) The role of chromatin during transcription Cell128(4):707-19
17. Raymond Camahort,Bing Li, Laurence Florens, Selene Swanson, Michael Washburn, and Jennifer Gerton (2007) Scm3 is essential to recruit the histone H3 variant Cse4 to centromeres and to maintain a functional kinetochoreMolecular Cell26(6):853-65
16.Bing Li, Madelaine Gogol, Mike Carey, Samantha Pattenden, Chris Seidel and Jerry Workman (2007) Infrequently transcribed long genes depend on the Set2/Rpd3S pathway for accurate transcriptionGenes& Development21(11):1422-30
15.Bing Li,Madelaine Gogol, Mike Carey, Daeyoup Lee, Chris Seidel and Jerry Workman (2007) Combined action of PHD and Chromo domains directs the Rpd3S HDAC to transcribed chromatin.Science316, 1050-1054
14. Michael Carey,Bing Li, Jerry L. Workman(2006) RSC Exploits Histone Acetylation to Abrogate the Nucleosomal Block to RNA Polymerase II Elongation Molecular Cell24, 481-487
13. Wei-Jong Shia,Bing Li, and Jerry L. Workman (2006) SAS-mediated acetylation of histone H4 Lys 16 is required for H2A.Z incorporation at subtelomeric regions inSaccharomyces cerevisiaeGenes &Development20: 2507-2512
12.Jingji Jin, Yong Cai,Bing Li,Ronald C. Conaway, Jerry L. Workman, Joan W.Conaway and Thomas Kusch (2005) In and out: histone variant exchange in chromatin.Trends in Biochem Sci.30(12): 680-687
11.Bing Li,Chun Ruan and Jerry Workman(2005) Histones: should I stay or should I go?Genome Biology 6:306
10.Bing Li,Samantha Pattenden, Daeyoup Lee, José Gutiérrez, Jie Chen, Chris Seidel, Jennifer Gerton and Jerry Workman (2005) Preferential occupancy of histone variant H2AZ at inactive promoters influence local histone modifications and chromatin remodeling Proc. Natl. Acad. Sci. USA102(51): 18385-18390
9. Michael. Carrozza, Bing Li, Laurence Florens, Tamaki Suganuma, Selene Swanson, Kenneth Lee,Wei-Jong Shia, Scott Anderson, John Yates, Michael Washburn and Jerry Workman (2005) Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription Cell123(4):581-92
8. Daeyoup Lee, Elena Ezhkova,Bing Li,Samantha Pattenden, William Tansey, Jerry Workman (2005) The Proteasome Regulatory Particle Alters the SAGA Coactivator to Enhance Its Interactions with Transcriptional Activators.Cell 123(3):423-36.
7.Yong Cai, Jing Jin, Laurence Florens, Selene Swanson, Thomas Kusch,Bing Li,Jerry Workman, Michael Washburn, Ronald Conaway, and Joan Conaway (2005) The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes. J Biol. Chem280(14):13665-70
6. Philippe Prochasson, Kristen E. Neely, Ahmed H. Hassan,Bing Liand Jerry L. Workman (2003) Targeting activity is required for SWI/SNF functionin vivoand is accomplished through two partially redundant activator interaction domains Molecular Cell12(4):983-990
5.Bing Li,LeAnn Howe, Scott Anderson, John Yates III and Jerry Workman (2003) The Set2 histone methyltransferase functions through the phosphorylated carboxyl-terminal domain of RNA polymerase II J Biol. Chem.278(11):8897-8903
4. Vishva M. Sharma,Bing Li, and Joseph Reese (2003) SWI/SNF dependent chromatin remodeling ofRNR3requires TAFIIs and the general transcription machinery Genes Dev.17: 502-515
3.Bing Liand Joseph Reese (2001) Ssn6-Tup1 RegulatesRNR3by Positioning Nucleosomes and Affecting the Chromatin Structure at the Upstream Repression Sequence.J. Biol. Chem.276(36): 33788-97.
2.Bing Liand Joseph Reese (2000) Derepression of DNA Damage-Regulated Genes Requires Yeast TBP-Associated Factors EMBO J.19(15):4091-100
1.Bing Li, Cheng Gu and Jindong Zhao (1998) Molecular cloning and expression of pfu DNA polymerase, and its application in long-distance PCR Chinese Science Bulletin43(10):863-867
团队介绍 >>>
成员组成：
伍均，博士，副研究员，邮箱：伍均<jun.wu@@shsmu.edu.cn>
宋娟，博士，副研究员，邮箱：宋娟<juansong1986@@outlook.com>
劳一敏，博士，助理研究员，邮箱：劳一敏<laoyi-ming@@hotmail.com>
彭梦媛，硕士，技术员，邮箱：彭梦媛<mengyuan@@shsmu.edu.cn>
薛敬冬，博士在读，邮箱：薛敬冬<xuejingdong02@@outlook.com>
潘奕萱，博士在读，邮箱：潘奕萱<penny-pan0609@@outlook.com>
俞铭，博士在读，邮箱：俞铭<Yu-Ming663581@@outlook.com>
李宁浙，博士在读（联合培养），邮箱：李宁浙<liningzhe111@@outlook.com>
许倩，博士在读（联合培养），邮箱：许倩<xqqingmo@@outlook.com>
郝彩芹，博士在读（联合培养），邮箱：郝彩芹<HaoCQ33@@outlook.com>
杨万里，硕士（毕业），邮箱：杨万里<wanliyang1993@@outlook.com>
张琪，硕士在读，邮箱：张琪<zhangq0319@@outlook.com>
田凯，硕士在读（联合培养），邮箱：田凯<tiankai_sjtu@@outlook.com>
何月，本科，邮箱：何月<heyue0929@@outlook.com>
卞林柯，本科，邮箱：卞林柯<linked.bian@@outlook.com>
吴欣睿，本科，邮箱：吴欣睿<carrol11111@@outlook.com>
江海宁，本科（毕业），邮箱：江海宁<jianghn7991@@outlook.com>
联系方式：
办公室地址：上海市重庆南路280号西7号楼213室
办公室电话：021-63846590-776696
邮 箱：bingli@shsmu.edu.cn
实验室地址：上海市重庆南路280号西7号楼213室
实验室电话：021-63846590-776695
