?

关键词 |

宋海云

 

 

时间:2019-08-01

 

浏览(

 

  宋海云



   职称:研究员

   学位:博士

   Email:songhaiyun@shsmu.edu.cn

 

1996年于南京大学获生物化学学士学位,1999年于南京大学获生物化学和分子生物学硕士学位,2005年于加州大学洛杉矶分校获生物化学和分子生物学博士学位。2005-2010年于瑞士苏黎世大学分子生物学研究所从事博士后研究。

2010年受聘于中科院上海生命科学研究院系统生物学重点实验室,任研究员、研究组长;2013-2017年任中科院上海生命科学研究院营养科学研究所研究员、研究组长;2017年起任上海交通大学医学院公共卫生学院研究员、研究组长。2010年入选中科院百人计划并获择优支持;2013年获国家优秀青年科学基金资助。

多年从事营养食品安全与代谢疾病研究。主要研究外因(如饮食、环境等)和内因(基因功能异常)诱导的信号通路的失调与营养健康的失衡及疾病发生的内在联系。通过研究从外界进入的纳米结构/载体和细胞内的调控因子对营养代谢和稳态维持信号通路的调控和干涉,阐明营养健康失衡及疾病发生的分子机理,为糖尿病、癌症、神经退行性疾病等重大疾病的预防与治疗提供应对手段或潜在靶点。

研究方向和成果

1、纳米技术的生物、医学应用:借助细胞间纳米结构塑造新型3D干细胞培养模型(2018, Adv Mater, IF=25.8);通过纳米载体增进肿瘤和代谢性疾病药物的靶向性和疗效(2018, Mater Horiz, IF=14.4; 2017, ACS AMI, IF=8.5)。

2、纳米结构与纳米载体的生物学效应:揭示食品用和医用纳米材料在代谢平衡、衰老和慢性疾病等生理和病理过程中的长期作用(2019, Mater Horiz, IF=14.4; 2016, Adv Mater, IF=25.8; 2014, Small, IF=10.8; 2016, Theranostics, IF=8.8; etc)。

3、营养代谢和稳态维持信号通路的分子机理:WntHippoJNKAMPK信号通路控制着包括胚胎和器官发育、代谢和稳态平衡、干细胞维持等重要生理和病变过程。这些信号通路的失调与多种重大疾病如糖尿病和癌症密切相关。我们致力于寻找这些信号通路中未知的调控基因和调节机制(2013, Dev Cell, IF=10.4; 2018, Cell Rep, IF=8.1; etc)。


近期通讯作者文章

:通讯作者;IF:影响因子)

1. Liu C#, Hu X#, Li X#, Zhou Y, Wang H, Fan C*, Song H*. Reprogramming of Cancer Invasiveness and Macrophage Education via a Nanostructured Antagonist of the TGFß Receptor. Mater Horiz. 2019 Apr 29. DOI: 10.1039/C9MH00388F. (*Corresponding author). (Epub ahead of print). IF=14.4

2. Li P, Ma Z, Yu Y, Hu X, Zhou Y, Song H*. FER promotes cell migration via regulating JNK  activity. Cell Prolif. 2019 Jul 1:e12656. doi: 10.1111/cpr.12656. (*Corresponding author). (Epub ahead of print). IF=5.0

3. Ma Z, Li P, Hu X, Song H*. Polarity Protein Canoe Mediates Overproliferation via Modulation of JNK, Ras-MAPK and Hippo Signaling. Cell Prolif. 2019 Jan; 52(1):e12529. (*Corresponding author). IF=5.0

4. Yu Y, Liu L, Li X, Hu X, Song H*. The histone H4K20 methyltransferase PR-Set7 fine-tunes the transcriptional activation of Wingless signaling in Drosophila.J Genet Genomics. 2019 Jan 20; 46(1):57-59. (*Corresponding author). IF=4.7

5. Li X#, Xie X#, Ma Z#, Li Q, Liu L, Hu X, Liu C, Li B, Wang H, Chen N*, Fan C*, Song H*. Programming Niche Accessibility and In Vitro Stemness with Intercellular DNA Reactions. Adv Mater. 2018 Nov 15; 30(46):e1804861. IF=25.8

6. Chen N#, Han Y#, Luo Y#, Zhou Y, Hu X, Yu Y, Xie X, Yin M, Sun J, Zhong W, Zhao Y, Song H*, Fan C*. Nanodiamonds-based non-canonical autophagy inhibitor synergistically induces cell death in oxygen-deprived tumors. Mater Horiz. 2018 Nov 1; 5(6):1204-1210. IF=14.4

7. Li P#, Huang P#, Li X#, Ma Z, Wang H, Song H*. Tankyrase Mediates K63-Linked Ubiquitination of JNK to Confer Stress Tolerance and Influence Lifespan in Drosophila. Cell Rep. 2018 Oct 9; 25(2):437-448. IF=8.1

8. Li X#, Song L#, Hu X, Liu C, Shi J, Wang H*, Zhan L*, Song H*. Inhibition of Epithelial-Mesenchymal Transition and Tissue Regeneration by Waterborne Titanium Dioxide Nanoparticles. ACS Appl Mater Interfaces. 2018 Jan 31; 10(4):3449-3458.IF=8.5

9. Liu C, Li P, Chen N, Jiang Y, Shi J, Fan C, Song H*. Titanium Dioxide Nanoparticles Trigger Non-Canonical Receptor Endocytosis to Inhibit Wnt Signaling. J Biomed Nanotechnol. 2017 Nov; 13(11):1522–1532.IF=5.1

10. Hu X#, Li X#, Yin M, Li P, Huang P, Wang L, Jiang Y, Wang H, Chen N*, Fan C*, Song H*. Nanodiamonds Mediate Oral Delivery of Proteins for Stem Cell Activation and Intestinal Remodeling in Drosophila. ACS Appl Mater Interfaces. 2017 Jun 7; 9(22):18575-18583.IF=8.5

11. Yi H#, Wang Z#, Li X#, Yin M, Wang L, Aldalbahi A, El-Sayed N, Wang H, Chen N*, Fan C*, Song H*. Silica nanoparticles target a Wnt signal transducer for degradation and impair embryonic development in Zebrafish. Theranostics. 2016 July 18; 6(11):1810-1820.IF=8.8

12. Yi H#, Li X#, Wang Z, Yin M, Wang L, Aldalbahi A, El-Sayed N, Wang H, Chen N, Chen L*, Fan C*, Song H*. Nanodiamonds interfere with Wnt-regulated cell migration and adipocyte differentiation in cells and embryonic development in vivo. Part Part Syst Char. 2017 Jan; 34(1):1600208. IF=4.5

13. Huang D, Li X, Sun L, Huang P, Ying H, Wang H, Wu J*, Song H*. Regulation of Hippo signaling by p38 signaling. J Mol Cell Biol. 2016 Aug 8; 8(4):328-37.IF=6.9

14. Li G#, Liu L#, Li P, Chen L*, Song H*, Zhang Y*. Gene expression profiling of selenophosphate synthetase 2 knockdown in Drosophila melanogaster.Metallomics. 2016 Mar 16; 8(3):354-65.IF=4.0

15. Zhang Y#, Wang Z#, Li X, Wang L, Yin M, Wang L, Chen N*, Fan C*, Song H*. Dietary iron oxide nanoparticles delay aging and ameliorate neurodegeneration in Drosophila. Adv Mater. 2016 Feb 17; 28(7):1387-93.IF=25.8

16. Chen N, Wang H, Huang Q, Li J, Yan J, He D, Fan C, Song H. Long-Term Effects of Nanoparticles on Nutrition and Metabolism. Small. 2014; 10(18):3603-11.IF=10.8

17. Yin D#, Huang P#, Wu J, Song H. Drosophila protein phosphatase V regulates lipid homeostasis via the AMPK pathway. J Mol Cell Biol. 2013 Dec; 6(1):100-2.IF=6.9

18. Zhong W, Lü M, Liu L, Sun J, Zhong Z, Zhao Y, Song H. Autophagy as new emerging cellular effect of nanomaterials. Sci Bull. 2013 Nov 25; 58(33):4031-8.IF=6.3

19. Schertel C#, Huang D#, Björklund M, Bischof J, Yin D, Li R, Wu Y, Zeng R, Wu J, Taipale J, Song H, Basler K. Systematic Screening of a Drosophila ORF Library In Vivo Uncovers Wnt/Wg Pathway Components. Dev Cell. 2013 Apr 29; 25(2):207-19.IF=10.4

20. Wen Y, Xu Y, Mao X, Wei Y, Song H, Chen N, Huang Q, Fan C, Li D. DNAzyme-Based Rolling-Circle Amplification DNA Machine for Ultrasensitive Analysis of MicroRNA in Drosophila Larva. Anal Chem. 2012 Sep 4; 84(18):7664-9.IF=6.4

21. Wang B, Chen N, Wei Y, Li J, Sun L, Wu J, Huang Q, Liu C, Fan C, Song H. Akt signaling-associated metabolic effects of dietary gold nanoparticles in Drosophila. Sci Rep. 2012; 2:563.IF=4.0


 

下一篇:王慧
重要信息: 未来学生 在校生 校友 教职工 支持单位
资料下载
 
 
进入编辑状态