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巴乾

 

 

时间:2017-07-28

 

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  巴乾


 

    职称:副研究员

    学历/学位:研究生/博士

    Email:qba@shsmu.edu.cn


 


 


 

研究方向:

立足于我国环境和食源性化学污染物、新材料、新食品原料等成分,从鉴定毒性效应、阐释作用机制、建立评估策略等层面,利用系统生物学、生物信息学和分子生物学手段,全面、系统性地探讨环境中食源性危害因素长期低剂量暴露的潜在健康风险和有害结局路径(AOP),开展“以体外人源细胞为模型、以毒性通路为核心、以作用方式为重点”的转化毒理学评价研究。

 

在研项目:

1.   上海市卫生系统优秀人才培养计划优秀青年人才,上海市卫生和计划生育委员会,2017-07~2020-06,课题负责人

2.   生命早期镉暴露协同维生素D缺乏引发个体肠道菌群紊乱导致代谢异常的机制及干预研究,国家自然科学基金委员会,重点项目,2017-01~2021-12,课题参与人

3.   上海高校教师产学研践习计划,上海市教育委员会,2017-01~2017-12,课题负责人

4.   镉暴露协同维生素D缺乏引发脂代谢异常的研究,上海交通大学,2016-09~2019-08,课题负责人

5.   纳米二氧化钛长期低剂量膳食摄入诱发肠道菌群紊乱进而导致免疫功能异常的机制研究,国家自然科学基金委员会,面上项目,2016-01~2019-12,课题负责人

 

主要成果:

1.   Huang C, Sun M, Yang Y, Wang F, Ma X, Li J, Y Wang, Ding Q, Ying H, Song H, Wu Y, Y Jiang, Jia X, Ba Q*, Wang H*. Titanium dioxide nanoparticles prime a specific activation state of macrophages. Nanotoxicology 2017, Accepted. (*共同通讯作者)

2.   Ba Q, Li X, Huang C, Li J, Fu Y, Chen P, Duan J, Hao M, Zhang Y, Li J, Sun C, Ying H, Song H, Zhang R, Shen Z, Wang H. BCCIPβ modulates the ribosomal and extraribosomal function of S7 through a direct interaction. J Mol Cell Biol 2017, 9(3):209-19.

3.   Ba Q, Li M, Chen P, Huang C, Duan X, Lu L, Li J, Chu R, Xie D, Song H, Wu Y, Ying H, Jia X, Wang H. Sex-dependent effects of cadmium exposure in early life on gut microbiota and fat accumulation in mice. Environ Health Perspect 2017, 125(3):437-44.

4.   Yao W, Ba Q, Li X, Li H, Zhang S, Yuan Y, Wang F, Duan X, Li J, Zhang W, Wang H. A natural CCR2 antagonist relieves tumor-associated macrophage-mediated immunosuppression to produce a therapeutic effect for liver cancer. EBioMedicine 2017, 22:58-67.

5.   Li C, Chen P, Duan X, Wang J, Shu B, Li X, Ba Q, Li J, Wang Y, Wang H. Bioavailable 25(OH)D but not total 25(OH)D is an independent determinant for bone mineral density in chinese postmenopausal women. EBioMedicine 2017, 15:184-192.

6.   Chen P, Duan X, Li M, Huang C, Li J, Chu R, Ying H, Song H, Jia X, Ba Q*, Wang H*. Topological, functional, and dynamic properties of the protein interaction networks rewired by benzo(a)pyrene. Toxicol Appl Pharmacol 2016, 310:150-8. (*共同通讯作者)

7.   Ba Q, Huang C, Fu Y, Li J, Chu R, Jia X, Wang H. Cumulative metabolic effects of low-dose benzo(a)pyrene exposure on human cells. Toxicol Res 2016, 5:107-15. (Hot articles in Toxicology Research)

8.   Li X, Zhou Y, Liu Y, Zhang X, Chen T, Chen K, Ba Q, Li J, Liu H, Wang H. Preclinical efficacy and safety assessment of artemisinin-chemotherapeutic agent conjugates for ovarian cancer. EBioMedicine 2016, 14:44-54.

9.   Zhang X*, Ba Q*, Gu Z*, Guo D, Zhou Y, Xu Y, Wang H, Ye D, Liu H. Fluorescent coumarin-artemisinin conjugates as mitochondria-targeting theranostic probes for enhanced anticancer activities. Chem Eur J 2015, 21(48):17415-21. (*共同第一作者)

10.  Ba Q, Li J, Huang C, Qiu H, Li J, Chu R, Zhang W, Xie D, Wu Y, Wang H. Effects of benzo[a]pyrene exposure on human hepatocellular carcinoma cell angiogenesis, metastasis, and NF-κB signaling. Environ Health Perspect 2015, 123(3):24654.

11.  Ba Q, Li J, Huang C, Li J, Chu R, Wu Y, Wang H. Topological, functional, and dynamic properties of the protein interaction networks rewired by benzo(a)pyrene. Toxicol Appl Pharmacol 2015, 283(2):8391.

12.  Yang C, Chen S, Zhou M, Li Y, Li Y, Zhang Z, Liu Z, Ba Q, Li J, Wang H, Yan X, Ma D, Wang R. Development of 3-phenyl-N-(2-(3-phenylureido)ethyl)-thiophene-2-sulfonamide compounds as inhibitors of antiapoptotic Bcl-2 family proteins. ChemMedChem 2014, 9(7):1436-52.

13.  Huang C*, Ba Q*, Yue Q, Li J, Li J, Chu R, Wang H. Artemisinin rewires the protein interaction network in cancer cells: network analysis, pathway identification, and target prediction. Mol Biosyst 2013, 9(12):3091-100. (*共同第一作者)

14.  Li J*, Ba Q*, Yin J*, Wu S, Zhuan F, Xu S, Li J, Salazar JK, Zhang W, Wang H. Surface display of recombinant drosophila melanogaster acetylcholinesterase for detection of organic phosphorus and carbamate pesticides. PLoS One 2013, 8(9):e72986. (*共同第一作者)

15.  Ba Q, Duan J, Tian J, Wang Z, Chen T, Li X, Chen P, Wu S, Xiang L, Li J, Chu R, Wang H. Dihydroartemisinin promotes angiogenesis during the early embryonic development of zebrafish. Acta Pharmacol Sin 2013, 34(8):1101-7.

16.  Ding X, Li Y, Lv L, Zhou M, Han L, Zhang Z, Ba Q, Li J, Wang H, Liu H, Wang R. De novo design, synthesis and evaluation of benzylpiperazine derivatives as highly selective binders of Mcl-1. ChemMedChem 2013, 8(12):1986-2014.

17.  Li X, Chen T, Lin S, Zhao J, Chen P, Ba Q, Guo H, Liu Y, Li J, Chu R, Shan L, Zhang W, Wang H. Valeriana jatamansi constituent IVHD-valtrate as a novel therapeutic agent to human ovarian cancer: in vitro and in vivo activities and mechanisms. Curr Cancer Drug Targets 2013, 13(4):472-83.

18.  Ba Q, Zhou N, Duan J, Chen T, Hao M, Yang X, Li J, Yin J, Chu R, Wang H. Dihydroartemisinin exerts its anticancer activity through depleting cellular iron via transferrin receptor-1. PLoS One 2012, 7(8):e42703.

19.  Ba Q, Hao M, Huang H, Hou J, Ge S, Zhang Z, Yin J, Chu R, Jiang H, Wang F, Chen K, Liu H, Wang H. Iron deprivation suppresses hepatocellular carcinoma growth in experimental studies. Clin Cancer Res 2011, 17(24):7625-33.

20.  Hao M*, Ba Q*, Yin J, Li J, Zhao Y and Wang H. Deglycosylated ginsenosides are more potent inducers of CYP1Al, CYP1A2 and CYP3A4 expression in HepG2 cells than glycosylated ginsenosides. Drug Metab Pharmacokinet 2011, 26(2):201-5. (*共同第一作者)

21.  Duan J, Ba Q, Wang Z, Hao M, Li X, Hu P, Zhang D, Zhang R, Wang H. Knockdown of ribosomal protein S7 causes developmental abnormalities via p53 dependent and independent pathways in zebrafish. Int J Biochem Cell Biol 2011, 43(8):1218-27.

22.  Xiao X, Hao M, Yang X, Ba Q, Li M, Ni S, Wang L, Du X. Licochalcone A inhibits growth of gastric cancer cells by arresting cell cycle progression and inducing apoptosis. Cancer Lett 2011, 302(1):69-75.

 

 

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