流行病学与生物统计学系

乔永霞/ 职称:副教授/硕士生导师

学历学位:博士 研究生

Email: Yongxia.qiao@shsmu.edu.cn

上海交通大学公共卫生学院流行病与生物统计学系副教授,硕导。临床医学专业和流行病与生物统计学背景,从事工作涉及肿瘤、心脑血管疾病、代谢性疾病、药物流行病、营养及运动干预、妇产科等方面的流行病学研究。上海交通大学医学院“九龙医学优秀青年人才提名奖”,上海市教委“优秀青年教师”资助培养,上海交通大学SMC-晨星优秀青年教师,上海交通大学医学院“优秀青年教师”资助培养。近五年,以第一/共一作者或通讯作者在Nature Communcations、Cell Reports、Diabetes等发表SCI论文8篇,累积影响因子分50分。


承担教学工作介绍

流行病学与生物统计学团队教学首席,承担本科生和研究生流行病学、营养流行病学、医学统计学、卫生统计学、科研设计与统计分析等课程主讲


主要研究方向

1. 肿瘤流行病学;

2. 心血管疾病流行病学;

3. 妇产科流行病学;

4. 行为干预。


主要研究课题

1.国家自然科学基金青年项目,81301689,糖尿病AGE/AGER信号通路调控YAP活性与 肝癌发生的机制及流行病学研究,2014/01-2016/12,23万,结题,主持;

2.国家自然科学基金面上项目,81872288,豆蔻酰化促肝癌的分子机制研究,2019/1-2022/12,57万,在研,主持。


主要研究成果

1、Jiayi Wang, Lifang Ma, Yue Zhang,Yongxia Qiao, Wenhao Weng, Jiangtu He, Qiuhui Pan, Yongchun Yu, Fenyong Sun. (2013). Mutual interaction between YAP and CREB promotes tumorigensis in liver cancer. Hepatology 58: 1011-1020 (IF: 11.665).

2、Jiayi Wang, Yue Zhang, Wenhao Weng,Yongxia Qiao, Lifang Ma, Weifan Xiao, Yongchun Yu, Qiuhui Pan*and Fenyong Sun*. Impaired phosphorylation and ubiquitination by P70 S6 kinase (P70S6K) and Smad ubiquitination regulatory factor 1 (Smurf1) promotes Tribbles homolog 2 (TRIB2) stability and carcinogenic property in liver cancer. (2013).J. Biol Chem.288: 33667-33681.

3、Jiayi Wang, Hongmei Wang, Yue Zhang, Ni Zhen, Li Zhang,Yongxia Qiao, WenhaoWeng, Xiangfan Liu, Lifang Ma, Weifan Xiao, Wenjun Yu, Qinghua Chu, Qiuhui Pan, Fenyong Sun*. Mutual inhibition between YAP and SRSF1 maintains long non-coding RNA, Malat1 induced tumorigenesis in liver cancer. (2014).Cell signal.26: 1048-1059.

4、Yongxia Qiao, Yue Zhang*, Jiayi Wang*.Ubiquitin E3 ligase SCFβ-TRCPregulates TRIB2 stability in liver cancer cells. (2013).Biochem. Biophy. Res. Commun.441: 555-559. (第一作者)

5、Lanlan Li, Jiayi Wang*, Yue Zhang, Yan Zhang, Lifang Ma, Wenhao Weng,Yongxia Qiao, Weifan Xiao, Hongmei Wang, Wenjun Yu, Qiuhui Pan, Yunyan He, Fenyong Sun*. MEK1 promotes YAP and their interaction is critical for tumorigensis in liver cancer. (2013).FEBS Lett.587:3921-3927.

6、Qiao Y, Tinker L, Olendzki B, Hébert JR, Balasubramanian R, Rosal MC, Hingle M, Song Y, Schneider KL, Liu S, Sims S, Ockene JK, Sepavich DM, Shikany JM, Persuitte G, and Ma Y*. Racial/Ethnic disparities in association between dietary quality and incident diabetes in postmenopausal women in the United States: The Women’s Health Initiative 1993- 2005. Ethnicity and Health.2014 Jun;19(3):328-47.(IF:1.2)

7、Yu W,Qiao Y, Tang X, Ma L, Wang Y, Zhang X, Weng W, Pan Q, Yu Y, Sun F, Wang J. Tumor suppressor long non-coding RNA, MT1DP is negatively regulated by YAP and Runx2 to inhibit FoxA1 in liver cancer cells. Cell Signal.2014 Sep 28;26(12):2961-2968(共同第一作者4.471)

8、Wenjun Yu, Jiayi Wang, Lifang Ma, Xun Tang,Yongxia Qiao, Quihui Pan, Yongchun Yu*, Fenyong Sun*. CD166 plays a pro-carcinogenic role in liver cancer cells via inhibition to FOXO proteins through AKT. (2014).Onco Rep.32: 677-683.

9、Wenjun Yu#,Yongxia Qiao#, Xun Tang, LifangMa, Yulan Wang, Xiao Zhang, Wenhao Weng ,Qiuhui Pan, Yongchun Yu, Fenyong Sun*, Jiayi Wang*. Tumor suppressor long non-coding RNA, MT1DP is negatively regulated by YAP and Runx2 to inhibit FoxA1 in liver cancer cells. (2014).Cell Signal.26: 2961–2968. (#,共同第一作者)

10、Shanshan Xu, Minghong Tong, Jingqin Huang, Yue Zhang,Yongxia Qiao, Wenhao Weng, Weiwei Liu, Jiayi Wang*, Fenyong Sun*. TRIB2 inhibits Wnt/b-Catenin/TCF4 signaling through its associated ubiquitin E3 ligases, b-TrCP, COP1 and Smurf1, in liver cancer cells. (2014).FEBS Lett.588: 4334-4341.

11、Lifang Ma, Jiafei Lin,Yongxia Qiao, Wenhao Weng, Weiwei Liu, Jiayi Wang*, Fenyong Sun*. Serum CD166: A novel hepatocellular carcinoma tumor marker. (2015).Clin Chim Acta.441: 156-162.

12、Jiayi Wang, Xun Tang, Wenhao Weng,Yongxia Qiao, Jiafei Lin, Weiwei Liu, Rui Liu, Lifang Ma, Wenjun Yu, Yongchun Yu, Qiuhui Pan*, Fenyong Sun*. The membrane protein Melanoma Cell Adhesion Molecule (MCAM) is a novel tumor marker that stimulates tumorigenesis in hepatocellular carcinoma. (2015).Oncogene.34: 5781-5795.

13、Xun Tang, Xianzhen Chen, Yanfeng Xu,Yongxia Qiao, Xiao Zhang, Yulan Wang, Yu Guan, Fenyong Sun*, Jiayi Wang*. CD166 positively regulates MCAM via inhibition to Ubiquitin E3 ligases Smurf1 and βTrCP through PI3K/AKT and c-Raf/MEK/ERK signaling in Bel-7402 hepatocellular carcinoma cells. (2015).Cell Signal.27: 1694-1702.

14、Jiayi Wang*, Lifang Ma, Xun Tang, Xiao Zhang,Yongxia Qiao, Yulin Shi, Yanfeng Xu, Zhongyong Wang, Yongchun Yu, Fenyong Sun*. Doxorubicin induces apoptosis by targeting Madcam1 and AKT and inhibiting protein translation initiation in hepatocellular carcinoma cells. (2015)Oncotarget. 6: 24075-24091.

15、Yongxia Qiao#, Xiao Zhang#, Yue Zhang#, Yulan Wang, Yanfeng Xu, Xiangfan Liu, Fenyong Sun*, Jiayi Wang*. High glucose stimulates tumorigenesis in hepatocellular carcinoma (HCC) cells through AGER-dependent O-GlcNAcylation of c-Jun. (2016).Diabetes. 65:619-632. (#,共同第一作者8.684)

16、Yulan Wang, Ran Cui, Xiao Zhang,Yongxia Qiao, Xiangfan Liu, Yefei Chang, Yongchun Yu, Fenyong Sun, Jiayi Wang. SIRT1 increases YAP- and MKK3-dependent p38 phosphorylation in mouse liver and human hepatocellular carcinoma.Oncotarget.2016,7 (10) :11284-11298

17、Yongxia Qiao#, Yunxia Qian,#Jiayi Wang,et.al. MCAM stimulates YAP transcription through enhancing CREB activity by c-Jun/c-Fos in hepatocellular carcinoma cells.Oncology letters. 11:3702-3708, 2016(#,共同第一作者IF:1.482)

18、Zhang X#, Sun F#,Qiao Y#, Zheng W, Liu Y, Chen Y, Wu Q, Liu X, Zhu G, Chen Y, Yu Y, Pan Q*, Wang J*.TFCP2 is required for YAP-dependent transcription to stimulate liver malignancy, Cell Reports, 2017, 21(5): 1227~1239(共同第一作者,IF:8.282)

19、Zhang X(#),Qiao Y(#), Wu Q, Chen Y, Zou S, Liu X, Zhu G, Zhao Y, Chen Y, Yu Y, Pan Q, Wang J(*), Sun F(*). The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis. Nature Communcations. 2017 May 5;8:15280.(共同第一作者,IF:12.124)

20、Chen Y, Liu R, Chu Z, Le B, Zeng H, Zhang X, Wu Q, Zhu G, Chen Y, Liu Y, Sun F, Lu Z,Qiao Y*, Wang J*. High glucose stimulates proliferative capacity of liver cancer cells possibly via O-GlcNAcylation-dependent transcriptional regulation of GJC1. J Cell Physiol. 2019Jan;234(1):606-618.(共同通讯作者,IF:3.923)

21、Xiao Zhang#, Lutao Du#,Yongxia Qiao#, Xiaobai Zhang#, Weisheng Zheng#, Qi Wu, Yan Chen, Guoqing Zhu, Ya Liu, Zhixuan Bian, Susu Guo, Yueyue Yang, Lifang Ma, Yongchun Yu, Qiuhui Pan*, Fenyong Sun*, Jiayi Wang*. Ferroptosis is governed by differential regulation of transcription in liver cancer. Redox Biol. 2019Jun;24:101211.(共同第一作者,IF=7.79)


获得荣誉称号

1.2013.9上海交通大学医学院 优秀青年教师培养

2.2014.9上海交通大学医学院 九龙医学优秀青年人才提名奖

3.2016.3上海交通大学医学院 优秀夜大学教师

4.2016年10月 上海交通大学 SMC-晨星优秀青年教师(C类)