食品安全与毒理学系

程薇/ 职称:助理研究员

学历学位:博士 研究生

Email: wcheng@shsmu.edu.cn


个人简介:

程薇,女,2017年毕业于上海交通大学,获医学博士学位。现就职于上海交通大学医学院公共卫生学院食品安全与毒理学系。


研究方向:

1. 毒性测试替代方法与转化毒理学;

2. 干细胞毒理学;

3. 化学品的健康风险评估;


主要研究课题:

1. 基于类器官的内分泌干扰物毒性快速检测系统的研究,在研,主持;

2. 基于类器官的外源化合物肝脏毒性替代测试体系的研究,在研,参加;

3. 食品中化学危害因子非定向筛查技术研究,在研,参加;

4. ER-EMT/CSC通路在大气细颗粒物有机组分致肺癌风险中的作用机制,在研,参加;

5. 基于人胚胎干细胞的环境内分泌干扰物低剂量暴露胚胎毒性评价模型的研究,结题,参加;

6. 化学品发育毒性评价的小鼠胚胎干细胞替代模型的研究,结题,参加;


主要研究成果:

1. Wei Cheng#, Xiaolan Li#, Shoufei Yang, Hui Wang, Yan Li, Yan Feng, Yan Wang*,Low doses of BPF induced hypertrophy in cardiomyocytes derived from human embryonic stem cells via disrupting the mitochondrial fission upon the interaction between ERβ and calcineurin A-DRP1 signaling pathway [J].Cell Biol Toxicol, accepted.

2. Wei Cheng, Shoufei Yang, Xiaolan Li, Fan Liang, Ren Zhou, Hui Wang, Yan Feng, Yan Wang*. Low doses of BPA induced abnormal mitochondrial fission and hypertrophy in human embryonic stem cell-derived cardiomyocytes via the calcineurin-DRP1 signaling pathway: A comparison between XX and XY cardiomyocytes [J].Toxicol Appl Pharmacol.2020, 388:114850.

3. Wei Cheng, Shoufei Yang, Fan Liang, Ren Zhou, Yan Li, Yan Feng, Yan Wang*. Low-dose exposure to triclosan disrupted osteogenic differentiation of mouse embryonic stem cells via BMP/ERK/Smad/Runx-2 signalling pathway [J]. Food Chem Toxicol. 2019, 127:1-10.

4. Wei Cheng, Ren Zhou, Fan Liang, Hongying Wei, Yan Feng, Yan Wang*. Application of mouse embryonic stem cell test to detect gender-specific effect of chemicals: a supplementary tool for embryotoxicity prediction [J]. Chem Res Toxicol. 2016,29(9):1519-1533.

5. Wei Cheng, Ren Zhou, Yan Feng*, Yan Wang*. Mainstream smoke and sidestream smoke affect the cardiac differentiation of mouse embryonic stem cells discriminately [J].Toxicology. 2016, 357:1-10.

6. Wei Cheng, Zhuo Yu, Lixin Feng, Yan Wang*. Perfluorooctane sulfonate (PFOS) induced embryotoxicity and disruption of cardiogenesis [J]. Toxicol In Vitro. 2013,27(5):1503-1512.

7. Ren Zhou, Wei Cheng, Yan Feng, Wei Wang, Fan Liang, Fei Luo, Shoufei Yang, Yan Wang*. Combined effects of BPA and PFOS on fetal cardiac development: in vitro and in vivo experiments [J]. Environ Toxcol Pharmacol, 2020, 80:103434.

8. Shoufei Yang, Wei Cheng, Xiaolan Li, Fan Liang, Ren Zhou, Hui Wang, Yan Feng, Yan Wang*.Use of embryonic stem cell-derived cardiomyocytes to study cardiotoxicity of bisphenol AF via the GPER/CAM/eNOS pathway [J]. Toxicology, 2020,432:152380.

9. Ren Zhou, Wei Cheng, Hongying Wei, Fan Liang, Yan Feng, Yan Wang*. Interactions between three typical endocrine-disrupting chemicals (EDCs) in binary mixtures exposure on myocardial differentiation of mouse embryonic stem cell [J]. Chemosphere. 2017, 178: 378-383.